Phosphorylated insulin‐like growth factor binding protein‐1 in cervical secretions and sonographic cervical length in the prediction of spontaneous preterm delivery

Paternoster, Delia Maria; Riboni, Francesca; Vitulo, Anna; Plebani, Mario; Dell'Avanzo, M.; Battagliarin, G.; Surico, N; Nicolini, Umberto

doi:10.1002/uog.6428

Cited by 28 publications

(12 citation statements)

References 15 publications

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“…14 Therefore, sonographically measured cervical length of >25mm with a negative phIGFBP-1 test in a symptomatic patient indicates a low risk of preterm delivery and may therefore allow avoidance of unnecessary therapies. 15 NPV for predicting the risk of pre-term delivery was increased on combining FFN assessment to cervical length measurements in present study also ( Table 3) similar to that of Audibert F et al 8 In asymptomatic high risk group both FFN and phIGFBP-1 tests were found to have poor sensitivity and PPV; however NPV of the tests were high. Cervical length in this group also had poor accuracy to predict preterm birth.…”

Section: Discussionsupporting

confidence: 85%

Double blinded study on comparison of phosphorylated insulin like growth factor binding protein 1 test and fetal fibronectin test for prediction of preterm delivery

Singhal

Sarda

Dhiman

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Recently new markers like fetal fibronectin (FFN) and phosphorylated Insulin like growth factor binding protein 1 (phIGFBP-1) have been found useful in diagnosis of pre-term labor. Fetal fibronectin (FFN) and phosphorylated Insulin like growth factor binding protein 1 (phIGFBP-1) were compared to predict the risk of pre- term delivery.Methods: Cervicovaginal samples of 50 symptomatic and 50 asymptomatic pregnant women were tested. Statistical analysis was done using chi square test, fisher’s exact test for qualitative data and for quantitative data unpaired student t test and Mann Whitney test were used.Results: For Symptomatic group phosphorylated Insulin like growth factor binding protein 1 (phIGFBP-1) and fetal fibronectin (FFN) had 100% sensitivity and 100% NPV for predicting delivery within 48 hours, 7days and 14 days. Specificity and PPV of FFN was higher than phIGFBP-1 to predict delivery (Specificity: within 48 hours 63.2% vs 52.6% within 7 days 72.7% vs 60.6%, within 14 days 75% vs 62.5%, ≤37 weeks 76% vs 56%; PPV: within 48 hours 46.2% vs 40%, within 7 days 65.4% vs 56.7%, within 14 days was 69.2% vs 60% and ≤37 weeks 76.9% vs 63%).Conclusions: Rapid bed side dip stick tests for detecting FFN and ph IGFBP-1 in cervicovaginal secretions are useful clinical adjuncts in ruling out delivery within 14 days of test in symptomatic patients, thus avoiding unnecessary hospital stay and medical interventions. However, FFN has slightly higher NPV in predicting risk of pre term delivery.

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Section: Discussionsupporting

confidence: 85%

Double blinded study on comparison of phosphorylated insulin like growth factor binding protein 1 test and fetal fibronectin test for prediction of preterm delivery

Singhal

Sarda

Dhiman

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…However, Deplange et al [15] reported that the sensitivity, specificity, PPV and NPV of cervical length ≤ 20 mm were 75, 52, 21 and 92% for delivery before 34 weeks. Additionally, Paternoster et al [16] found that 26 mm was the best cut-off value for cervical length in terms of predicting preterm delivery with a sensitivity of 86.4%, specificity of 71.9%, PPV of 34.5% and NPV of 96.8%.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of transvaginal ultrasonography, power Doppler indices, electromyography and serum protein 53 level in prediction for preterm labour

Abdelghany

2018

Evidence Based Women's Health Journal

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Objective: The objective of this study is to evaluate the role of cervical length measurement by transvaginal ultrasonography, power Doppler of the uteroplacental circulation, electromyography and serum protein 53 level (p53) in prediction for preterm labour (PTL). Study Design : A prospective observational study. Patients and Methods: The study was conducted at the outpatient clinic of El-Minia University Hospital, Egypt during the period from January 2012 to December 2014. The study included a total of 100 pregnant women at high risk for preterm labor. All included cases were subjected to transvaginal cervical sonography, power Doppler velocimetry and uterine electromyography measurements (EMG), also, serum protein 53 level was determined. Results: The included subjects were classified into two groups according to gestational age at labor: Group (I): patients delivered before < 35 weeks (n=42) and group (II): patients delivered ≥ 35 weeks (n=58). Group (I) had significantly lower cervical length compared to group II (2.86 ± 0.81vs. 3.23 ± 0.67 cm) (P=0.013). There was a significant difference between groups as regards EMG (P = 0.006). No statistically differences were found between groups as regards Doppler indices (both resistance and pulsatility index). Group (I) had significantly higher maternal serum concentration of P53 compared to group II (473.8 ± 146.5 vs. 404.6 ± 164.7 pg/ml), (P≤ 0.01). Serum P 53 level had the higher sensitivity for prediction of PTL (78.6%), however, power Doppler indices had the lowest sensitivity (RI = 23.8% and PI =19.1%), cervical length had sensitivity of 33.3% however, EMG positive parameters had sensitivity of 40.5 % and specificity of 100.0%. Conclusion: From the studied tools for prediction of preterm delivery, different results were obtained, but serum P53 level was the most sensitive and the best option for prediction of preterm delivery, while, power Doppler indices are the least sensitive. However, EMG positive parameters are the most specific for prediction of PTL.

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“…They concluded that two tests are independent, as shown by multivariate analysis. Paternoster et al [17] assessed both parameters in 201 patients with threatened preterm labor and determined cervical length cut off to be 26 mm with sensitivity, specificity, PPV and NPV of 86.4%, 71.9%, 34.5% and 96.8% respectively and having odds ratio of 16.18 (4.46-58.66). These parameters for phIGFBP-1 were 52.9%, 89.2%, 48.7% and 90.8% respectively with odds ratio of 9.29 (4.05-21.3).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Phosphorylated Insulin like Growth Factor Binding Protein-1 and Sonographically Measured Cervical Length for Prediction of Preterm Birth in Threatened Preterm Labor: A Clinical Approach

Tripathi¹,

Tyagi²,

Yadav³

et al. 2017

IPCB

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Background and Objectives: Measurement of cervical length using Transvaginal Sonography (TVS) is commonly used to identify those patients of threatened preterm labor who are likely to deliver. Biochemical markers in cervical secretions namely fetal fibronectin and Phosphorylated Insulin like Growth Factor Binding Protien-1 (phIGFBP-1) have also been used to improve predictability. This study evaluated bedside kit test for phIGFBP-1 and cervical length measurement by TVS, individually and in combination, for prediction of preterm birth in patients with threatened preterm labor.

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Phosphorylated insulin‐like growth factor binding protein‐1 in cervical secretions and sonographic cervical length in the prediction of spontaneous preterm delivery

Abstract: K E Y W O R D S:

Cited by 28 publications

References 15 publications

Double blinded study on comparison of phosphorylated insulin like growth factor binding protein 1 test and fetal fibronectin test for prediction of preterm delivery

Double blinded study on comparison of phosphorylated insulin like growth factor binding protein 1 test and fetal fibronectin test for prediction of preterm delivery

Evaluation of transvaginal ultrasonography, power Doppler indices, electromyography and serum protein 53 level in prediction for preterm labour

Evaluation of Phosphorylated Insulin like Growth Factor Binding Protein-1 and Sonographically Measured Cervical Length for Prediction of Preterm Birth in Threatened Preterm Labor: A Clinical Approach

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