Photoacoustic imaging: a potential tool to detect early indicators of metastasis

Bayer, Carolyn L.; Joshi, Pratixa P.; Emelianov, Stanislav

doi:10.1586/erd.12.62

Cited by 22 publications

(14 citation statements)

References 89 publications

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“…38,39 This hypothesis is particularly attractive in patients whose metastatic tumors are small or in locations that may not be amenable to other modalities that serve to augment treatment response to immunotherapy, such as radiation or the injection of cytolytic tumor vaccines. LA-PAT can also be applied to image CTCs in the lymph, 40 but the weak optical absorption of lymph may require labeling in order to locate the lymphatic system. In addition to CTC detection, LA-PAT can measure other parameters, including depth, pH, oxygen saturation, stiffness, glucose metabolism, angiogenesis, and therapy response, to provide comprehensive information about solid tumors and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Hai

et al. 2020

J. Biomed. Opt.

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Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention.Aim: We aim to demonstrate label-free imaging of suspected melanoma CTCs.Approach: We use a linear-array-based photoacoustic tomography system (LA-PAT) to detect melanoma CTCs, quantify their contrast-to-noise ratios (CNRs), and measure their flow velocities in most of the superficial veins in humans.Results: With LA-PAT, we successfully imaged suspected melanoma CTCs in patients in vivo, with a CNR >9. CTCs were detected in 3 of 16 patients with stage III or IV melanoma. Among the three CTC-positive patients, two had disease progression; among the 13 CTC-negative patients, 4 showed disease progression. Conclusions:We suggest that LA-PAT can detect suspected melanoma CTCs in patients in vivo and has potential clinical applications for disease monitoring in melanoma.

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Section: Discussionmentioning

confidence: 99%

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Hai

et al. 2020

J. Biomed. Opt.

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“…So far, PAT has been explored in numerous preclinical and clinical studies. In particular, PAT has made considerable progress in detecting early-stage cancers [23], assessing skin lesions [24], imaging brain activities [25], mapping sentinel lymph nodes [26], monitoring drug or contrast agent delivery [27, 28], and performing endoscopic examinations [29]. The following achievements in the year 2013 particularly deserve to be highlighted.…”

Section: Highlights In Pat Biomedical Applicationsmentioning

confidence: 99%

Breakthroughs in Photonics 2013: Photoacoustic Tomography in Biomedicine

Yao

Wang

2014

IEEE Photonics J.

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Photoacoustic tomography (PAT) is one of the fastest growing biomedical imaging modalities in the last decade. Building on its high scalability and complementary imaging contrast to other mainstream modalities, PAT has gained substantial momentum in both preclinical and clinical studies. In 2013, PAT has grown markedly in both its technological capabilities and biomedical applications. In particular, breakthroughs have been made in super-resolution imaging, deep blood flow measurement, small animal resting state brain mapping, video rate functional human imaging, and human breast imaging. These breakthroughs have either successfully solved long-standing technical issues in PAT or significantly enhanced its imaging capability. This Review will summarize state-of-the-art developments in PAT and highlight a few representative achievements of the year 2013.

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“…US-PA has thus far been investigated for various preclinical applications such as intravascular imaging of atherosclerotic plaques, tumor detection and staging, in vivo stem cell tracking. [43][44][45][46][47] To the best of our knowledge, till date, the potential benefits of US-PA in the field of tissue engineering have not been explored. Therefore, in this study, we investigate the suitability of a multimodal US-PA system to image tissue engineering scaffolds and monitor oxygen saturation in vivo in a rat model.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Ultrasound-Photoacoustic Imaging of Tissue Engineering Scaffolds and Blood Oxygen Saturation In and Around the Scaffolds

Talukdar

Avti

Sun

et al. 2014

Tissue Engineering Part C: Methods

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Preclinical, noninvasive imaging of tissue engineering polymeric scaffold structure and/or the physiological processes such as blood oxygenation remains a challenge. In vitro or ex vivo, the widely used scaffold characterization modalities such as porosimetry, electron or optical microscopy, and X-ray microcomputed tomography have limitations or disadvantages-some are invasive or destructive, others have limited tissue penetration (few hundred micrometers) and/or show poor contrast under physiological conditions. Postmortem histological analysis, the most robust technique for the evaluation of neovascularization is obviously not appropriate for acquiring physiological or longitudinal data. In this study, we have explored the potential of ultrasound (US)-coregistered photoacoustic (PA) imaging as a noninvasive multimodal imaging modality to overcome some of the above challenges and/or provide complementary information. US-PA imaging was employed to characterize poly(lactic-co-glycolic acid) (PLGA) polymer scaffolds or single-walled carbon nanotube (SWCNT)-incorporated PLGA (SWCNT-PLGA) polymer scaffolds as well as blood oxygen saturation within and around the scaffolds. Ex vivo, PLGA and SWCNT-PLGA scaffolds were placed at 0.5, 2, and 6 mm depths in chicken breast tissues. PLGA scaffolds could be localized with US imaging, but generate no PA signal (excitation wavelengths 680 and 780 nm). SWCNT-PLGA scaffolds generated strong PA signals at both wavelengths due to the presence of the SWCNTs and could be localized with both US and PA imaging depths between 0.5-6 mm (lateral resolution = 90 μm, axial resolution = 40 μm). In vivo, PLGA and SWCNT-PLGA scaffolds were implanted in subcutaneous pockets at 2 mm depth in rats, and imaged at 7 and 14 days postsurgery. The anatomical position of both the scaffolds could be determined from the US images. Only SWCNT-PLGA scaffolds could be easily detected in the US-PA images. SWCNT-PLGA scaffolds had significant four times higher PA signal intensity compared with the surrounding tissue and PLGA scaffolds. In vivo blood oxygen saturation maps around and within the PLGA scaffolds could be obtained by PA imaging. There was no significant difference in oxygen saturation for the PLGA scaffolds at the two time points. The blood oxygen saturation maps complemented the histological analysis of neovascularization of the PLGA scaffolds.

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Photoacoustic imaging: a potential tool to detect early indicators of metastasis

Cited by 22 publications

References 89 publications

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo

Breakthroughs in Photonics 2013: Photoacoustic Tomography in Biomedicine

Multimodal Ultrasound-Photoacoustic Imaging of Tissue Engineering Scaffolds and Blood Oxygen Saturation In and Around the Scaffolds

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