Photoacoustic imaging system visualizes restoration of peripheral oxygenation in psoriatic lesions

Ishida, Yoshihiro; Otsuka, Atsushi; Honda, Tetsuya; Asao, Yasufumi; Sekiguchi, Hiroyuki; Yoshikawa, Aya; Yagi, T.; Kabashima, Kenji

doi:10.1111/jdv.15032

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Similar to the results of the phantom experiments, as shown in Figure 9a and other figures, PA images of blood vessels could be reconstructed with definition equal to or higher than that of the previous prototypes 6– 8 .…”

Section: Resultssupporting

confidence: 79%

Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs

et al. 2019

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Background: A breast-specific photoacoustic imaging (PAI) system prototype equipped with a hemispherical detector array (HDA) has been reported as a promising system configuration for providing high morphological reproducibility for vascular structures in living bodies. Methods: To image the vasculature of human limbs, a newly designed PAI system prototype (PAI-05) with an HDA with a higher density sensor arrangement was developed. The basic device configuration mimicked that of a previously reported breast-specific PAI system. A new imaging table and a holding tray for imaging a subject's limb were adopted. Results: The device’s performance was verified using a phantom. Contrast of 8.5 was obtained at a depth of 2 cm, and the viewing angle reached up to 70 degrees, showing sufficient performance for limb imaging. An arbitrary wavelength was set, and a reasonable PA signal intensity dependent on the wavelength was obtained. To prove the concept of imaging human limbs, various parts of the subject were scanned. High-quality still images of a living human with a wider size than that previously reported were obtained by scanning within the horizontal plane and averaging the images. The maximum field of view (FOV) was 270 mm × 180 mm. Even in movie mode, one-shot 3D volumetric data were obtained in an FOV range of 20 mm in diameter, which is larger than values in previous reports. By continuously acquiring these images, we were able to produce motion pictures. Conclusion: We developed a PAI prototype system equipped with an HDA suitable for imaging limbs. As a result, the subject could be scanned over a wide range while in a more comfortable position, and high-quality still images and motion pictures could be obtained.

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Section: Resultssupporting

confidence: 79%

Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs

et al. 2019

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“…Other microscopic OA imaging systems have further demonstrated a powerful performance for the characterization of psoriasis. 113,114 Inflammation-related alterations to the dermal vasculature are similarly present in Eczema with dilation and increased vessel density clearly observed in the OA images, although the capillary loops appear to be sparser and more irregularly distributed than in psoriasis. 111…”

Section: Psoriasis and Eczemamentioning

confidence: 94%

Optoacoustic imaging of the skin

Deán‐Ben

Razansky

2021

Experimental Dermatology

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Optoacoustic (OA, photoacoustic) imaging capitalizes on the synergistic combination of light excitation and ultrasound detection to empower biological and clinical investigations with rich optical contrast while effectively bridging the gap between micro and macroscopic imaging realms. State-of-the-art OA embodiments consistently provide images at micron-scale resolution through superficial tissue layers by means of focused illumination that can be smoothly exchanged for acoustic-resolution images at diffuse light depths of several millimetres to centimetres via ultrasound beamforming or tomographic reconstruction. Taken together, this unique multi-scale imaging capacity opens unprecedented capabilities for high-resolution in vivo interrogations of the skin at scalable depths. Moreover, diverse anatomical and functional information is retrieved via dynamic mapping of endogenous chromophores such as haemoglobin, melanin, lipids, collagen, water and others. This, along with the use of non-ionizing radiation, facilitates a clinical translation of the OA modalities. We review recent progress in OA imaging of the skin in preclinical and clinical studies exploiting the rich contrast provided by endogenous substances in tissues. The imaging capabilities of existing approaches are discussed in the context of initial translational studies on skin cancer, inflammatory skin diseases, wounds and other conditions.

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“…The acanthosis of the skin lesions may cause high scattering within the tissues and may limit the imaging depth of OCT, diminishing the visibility of dermal structural features. Another inflammation indicator could potentially be the oxygenation status of the vessels measured via PAI as reported by Ishida et al [93]. After a week post-treatment with ixekizumab of a patient with psoriasis on extremity digits, the oxygenation saturation level increased from 72 % to 89 % in the palmar digital veins.…”

Section: Clinical Applications Of Photoacoustic Imagingmentioning

confidence: 97%

A review of clinical photoacoustic imaging: Current and future trends

et al. 2019

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Photoacoustic imaging (or optoacoustic imaging) is an upcoming biomedical imaging modality availing the benefits of optical resolution and acoustic depth of penetration. With its capacity to offer structural, functional, molecular and kinetic information making use of either endogenous contrast agents like hemoglobin, lipid, melanin and water or a variety of exogenous contrast agents or both, PAI has demonstrated promising potential in a wide range of preclinical and clinical applications. This review provides an overview of the rapidly expanding clinical applications of photoacoustic imaging including breast imaging, dermatologic imaging, vascular imaging, carotid artery imaging, musculoskeletal imaging, gastrointestinal imaging and adipose tissue imaging and the future directives utilizing different configurations of photoacoustic imaging. Particular emphasis is placed on investigations performed on human or human specimens.

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Photoacoustic imaging system visualizes restoration of peripheral oxygenation in psoriatic lesions

Cited by 10 publications

References 7 publications

Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs

Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs

Optoacoustic imaging of the skin

A review of clinical photoacoustic imaging: Current and future trends

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