Photobiomodulation with LED and laser in repair of mandibular socket rabbit: clinical evaluation, histological, and histomorphometric

Comunian, Cláudio Rômulo; Custódio, Antônio Luís Neto; Oliveira, Leandro Junqueira; Dutra, Carlos Eduardo Assis; Neto, Milton D'almeida Ferreira; Rezende, Cleuza Maria Faria

doi:10.1007/s10006-017-0619-0

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…Photobiomodulation from LED increases bone metabolism and accelerates fracture healing. Our results corroborate findings in other research studies [ 38 , 59 , 64 ], which have also found evidence of the optimization of bone repair in fractures in a period prior to 30 days.…”

Section: Resultssupporting

confidence: 93%

“…GelMA increases bone tissue due to its inherent bioactivity and physicalchemical adaptability [69], and due to its porous architecture, it promotes migration, proliferation and osteogenic and chondrogenic differentiation [13,70]. In studies reported by Comunian et al and Ekizer et al [43,64], who evaluated photobiomodulation in bone repair, it was verified that this modality enabled the improvement of neoformation and the quality of the formed bone tissue. This is because photobiomodulation promotes the increased synthesis of the number of osteocytes, collagen and DNA synthesis, proliferation and the differentiation of osteoblasts, in addition to cell metabolism [43,44].…”

Section: In Vivo Experimentsmentioning

confidence: 94%

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Evaluation of How Methacrylate Gelatin Hydrogel Loaded with Ximenia americana L. Extract (Steam Bark) Effects Bone Repair Activity Using Rats as Models

Leal,

Gusmão,

Uchôa

et al. 2023

JFB

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The use of bioactive materials, such as Ximenia americana L., to stimulate the bone repair process has already been studied; however, the synergistic effects of its association with light emitting diode (LED) have not been reported. The present work aims to evaluate the effect of its stem bark extract incorporated into methacrylate gelatin hydrogel (GelMA) on the bone repair process using pure hydrogel and hydrogel associated with LED therapy. For this purpose, the GelMA hydrogel loaded with Ximenia americana L. extract (steam bark) was produced, characterized and applied in animal experiments. The tests were performed using 50 male Wistar rats (divided into 5 groups) submitted to an induced tibia diaphyseal fracture. The therapy effects were verified for a period of 15 and 30 days of treatment using histological analysis and Raman spectroscopy. After 15 days of induced lesion/treatment, the new bone formation was significantly higher in the GXG (GelMA + X. americana L.) group compared to the control group (p < 0.0001). After 30 days, a statistically significant difference was observed when comparing the GXLEDG (GelMA + X. americana L. + LED) and the control group (p < 0.0001), the GXG and the control group (p < 0.001), and when comparing the GG, GXG (p < 0.005) and GXLEDG (p < 0.001) groups. The results shows that the Ximenia americana L. stem extract incorporated into GelMA hydrogel associated with LED therapy is a potentiator for animal bone repair.

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Section: Resultssupporting

confidence: 93%

Section: In Vivo Experimentsmentioning

confidence: 94%

Evaluation of How Methacrylate Gelatin Hydrogel Loaded with Ximenia americana L. Extract (Steam Bark) Effects Bone Repair Activity Using Rats as Models

Leal,

Gusmão,

Uchôa

et al. 2023

JFB

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“…On the topic of our review, among the 17 papers taken into account, nine were performed using animal models [54][55][56][57][58][59][60][61][62]. However, the animals investigated were prevalently rats [54][55][56][57][58][59] and in two cases, rabbits [60,61]; a dog model was surprisingly employed only in one recent work [62].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, in accordance with Schropp [9], studies with at least 8 weeks of follow-up could better describe the effect of PBM on bone healing and its possible resorption. Concerning the wavelengths, it is not strange that the only two studies [61,68] that showed no effect of PBM in animal and human models used wavelengths below 800 nm. It is known that wavelengths in the range of 800-980 nm allow better tissue penetration [82,83] than lower and higher ones, and can reach a deeper therapy target, such as bone.…”

Section: Discussionmentioning

confidence: 99%

Interaction between Laser Light and Osteoblasts: Photobiomodulation as a Trend in the Management of Socket Bone Preservation—A Review

Amaroli

Colombo

Zekiy

et al. 2020

Biology

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Bone defects are the main reason for aesthetic and functional disability, which negatively affect patient’s quality of life. Particularly, after tooth extraction, the bone of the alveolar process resorbs, limiting the optimal prosthetic implant placement. One of the major pathophysiological events in slowly- or non-healing tissues is a blood supply deficiency, followed by a significant decrease in cellular energy amount. The literature shows that photons at the red and infrared wavelengths can interact with specific photoacceptors located within the cell. Through this mechanism, photobiomodulation (PBM) can modify cellular metabolism, by increasing mitochondrial ATP production. Here, we present a review of the literature on the effect of PBM on bone healing, for the management of socket preservation. A search strategy was developed in line with the PRISMA statement. The PubMed and Scholar electronic databases were consulted to search for in vivo studies, with restrictions on the year (<50 years-old), language (English), bone socket preservation, and PBM. Following the search strategy, we identified 269 records, which became 14, after duplicates were removed and titles, abstract and inclusion-, exclusion-criteria were screened. Additional articles identified were 3. Therefore, 17 articles were included in the synthesis. We highlight the osteoblast–light interaction, and the in vivo therapeutic tool of PBM is discussed.

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“…Comunian, Custódio et al, 32 compared the effects of low-level lasers with LED. For this experiment 18 rabbits were divided into 3 groups.…”

Section: Discussionmentioning

confidence: 99%

To evaluate the effects of Low-level laser therapy (LLLT) on wound healing of extraction socket: A systematic review

Karim

Husein

Qamruddin³

et al. 2023

Bangladesh J Med Sci

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Background: Low power laser therapy or low-level laser therapy (LLLT) is relatively novel and has demonstrated tremendous advantages in dentistry which includes reduction in post-surgical pain as well as swelling and also accelerates wound healing and helps in bone regeneration etc. Objective: This systematic review aimed to find out whether low-level laser therapy promotes tooth extraction wound healing. Materials and Methods: Literature was searched from January 2010 till 31 December 2020 using PubMed, Scopus, and Web of science. Further findings were done from gray literature google scholar, and Research Gate using Low-level laser therapy, photobiomodulation, wound healing, extraction socket healing, cold laser, biostimulation, low-level laser irradiation, and phototherapy. Any article that reported effects of low-level laser therapy on wound healing was included. 19 studies fulfilled the criteria and were included for this systematic review. Quality assessment was done for each article using Joanna Briggs Institute (JBI) checklist for analytical cross-sectional studies. Results and Discussion: Throughout the search, approximately 22,808 relevant articles were found. Out of which 50 articles fulfilled the selection criteria. 31 articles were excluded because that did not fulfill inclusion criteria. 19 articles were included for this systematic review that compared the effects of low level-laser therapy on wound healing after extraction of a tooth. Conclusion: Overall, this systematic review concluded that low-level laser therapy enhanced the process of wound healing after extraction of teeth but most of the research was conducted on animals. Further research is needed to investigate the biostimulatory effects of low-level irradiation on wound healing after extraction of a tooth Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 585-597

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Photobiomodulation with LED and laser in repair of mandibular socket rabbit: clinical evaluation, histological, and histomorphometric

Abstract: It was found that photobiomodulation with LASER and LED presented effects. However, only the LED demonstrated a beneficial effect on the process of bone repair in the dental alveoli of rabbits.

Cited by 8 publications

References 19 publications

Evaluation of How Methacrylate Gelatin Hydrogel Loaded with Ximenia americana L. Extract (Steam Bark) Effects Bone Repair Activity Using Rats as Models

Evaluation of How Methacrylate Gelatin Hydrogel Loaded with Ximenia americana L. Extract (Steam Bark) Effects Bone Repair Activity Using Rats as Models

Interaction between Laser Light and Osteoblasts: Photobiomodulation as a Trend in the Management of Socket Bone Preservation—A Review

To evaluate the effects of Low-level laser therapy (LLLT) on wound healing of extraction socket: A systematic review

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