Photocatalysis/enzymolysis-based biomimetic Schottky junction reduces tumor interstitial solid and fluid phases for deep-penetrating tumor therapy

Hao, Zining; He, Yuchu; Wang, Jing; Zhang, Xuwu; Ye, Fei; Guan, Ze; Liu, Xiaokang; Ma, Zhenhe; Yuan, Yi; Li, Hongming; Gao, Dawei

doi:10.1016/j.cej.2022.137196

Cited by 7 publications

(8 citation statements)

References 22 publications

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“…3d). 33 This method enables synchronous decomposition of both solid and liquid phases of the tumor interstitium, enhancing the targeting, penetration, and therapeutic efficacy of nanomaterials. 33 Nanomaterials can also reduce ECM stiffness through their inherent properties, in addition to drug loading capabilities.…”

Section: Normalization Of Tumor Microenvironment Mechanics By Targeti...mentioning

confidence: 99%

The application of nanomaterials in tumor therapy based on the regulation of mechanical properties

Wang,

Yu,

Liu

et al. 2024

Nanoscale

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Section: Normalization Of Tumor Microenvironment Mechanics By Targeti...mentioning

confidence: 99%

The application of nanomaterials in tumor therapy based on the regulation of mechanical properties

Wang,

Yu,

Liu

et al. 2024

Nanoscale

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“…These two effects synergistically contribute to the patency of the peritumor vasculature, further increasing the O 2 content in the tumor site. [223] Besides, gold nanoparticles can dramatically enhance blood perfusion, which can normalize blood vessels and reduce tissue hypoxia. [224][225][226][227] Huang et al developed an innovative targeting polymer and folic acid-modified gold nanoparticles (AuNPP-FA) without resorting to any therapeutic drugs.…”

Section: Blood Perfusion Enhancement Nanoplatformmentioning

confidence: 99%

“…AuHQ treatment increases pericyte coverage, regulates tumor leakage, reduces tumor hypoxia, and increases blood perfusion, resulting in tumor vasculature normalization. [226] Enhanced blood perfusion can fundamentally alleviate tumor hypoxia, but currently, there is a lack of therapeutic strategies to significantly improve blood perfusion, and the construction of [223] Copyright 2022, Elsevier B.V. b) Schematic illustration of AuNPP-FA promoting tumor vascular normalization. Reproduced with permission.…”

Section: Blood Perfusion Enhancement Nanoplatformmentioning

confidence: 99%

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Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Shen

Chen

Zhao

et al. 2023

Adv Healthcare Materials

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Hypoxia is a typical feature of most solid tumors and has important effects on tumor cells' proliferation, invasion, and metastasis. This is the key factor that leads to poor efficacy of different kinds of therapy including chemotherapy, radiotherapy, photodynamic therapy, etc. In recent years, the construction of hypoxia‐relieving functional nanoplatforms through nanotechnology has become a new strategy to reverse the current situation of tumor microenvironment hypoxia and improve the effectiveness of tumor treatment. Here, the main strategies and recent progress in constructing nanoplatforms are focused on to directly carry oxygen, generate oxygen in situ, inhibit mitochondrial respiration, and enhance blood perfusion to alleviate tumor hypoxia. The advantages and disadvantages of these nanoplatforms are compared. Meanwhile, nanoplatforms based on organic and inorganic substances are also summarized and classified. Through the comprehensive overview, it is hoped that the summary of these nanoplatforms for alleviating hypoxia could provide new enlightenment and prospects for the construction of nanomaterials in this field.

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“…By utilizing processes such as photocatalysis and piezoelectric catalysis to decompose excess water within the tumor, we were able to subsequently reduce interstitial fluid pressure. This led to an improvement in local blood perfusion within the tumor, enhancing the delivery efficiency of nano-drugs within the tumor [ 8 , 9 , 16 ]. These findings provide ample evidence for the feasibility of this therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%

Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis

Zhang,

Liu

et al. 2024

J Nanobiotechnol

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Background Elevated interstitial fluid pressure within tumors, resulting from impaired lymphatic drainage, constitutes a critical barrier to effective drug penetration and therapeutic outcomes. Results In this study, based on the photosynthetic characteristics of algae, an active drug carrier (CP@ICG) derived from Chlorella pyrenoidosa (CP) was designed and constructed. Leveraging the hypoxia tropism and phototropism exhibited by CP, we achieved targeted transport of the carrier to tumor sites. Additionally, dual near-infrared (NIR) irradiation at the tumor site facilitated photosynthesis in CP, enabling the breakdown of excessive intratumoral interstitial fluid by generating oxygen from water decomposition. This process effectively reduced the interstitial pressure, thereby promoting enhanced perfusion of blood into the tumor, significantly improving deep-seated penetration of chemotherapeutic agents, and alleviating tumor hypoxia. Conclusions CP@ICG demonstrated a combined effect of photothermal/photodynamic/starvation therapy, exhibiting excellent in vitro/in vivo anti-tumor efficacy and favorable biocompatibility. This work provides a scientific foundation for the application of microbial-enhanced intratumoral drug delivery and tumor therapy. Graphical Abstract

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Photocatalysis/enzymolysis-based biomimetic Schottky junction reduces tumor interstitial solid and fluid phases for deep-penetrating tumor therapy

Cited by 7 publications

References 22 publications

The application of nanomaterials in tumor therapy based on the regulation of mechanical properties

The application of nanomaterials in tumor therapy based on the regulation of mechanical properties

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis

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