Photocured Poly(Mannitol Sebacate) with Functional Methacrylic Monomer: Analysis of Physical, Chemical, and Biological Properties

Abstract

In this work, we described the formation of polymeric networks with potential antimicrobial character based on an acrylate oligomer, poly(mannitol sebacate) (PMS), and an enzymatically synthesized methacrylic monomer with thiazole groups (MTA). Networks with different content of MTA were prepared, and further physico-chemically characterized by microhardness, water contact angle measurements, and differential scanning calorimetry. Monomer incorporation into the networks and subsequent quaternization to provide thiazolium moieties affected the mechanical behavior and the surface wettability of the networks. Moreover, the introduction of permanent cationic charges in the network surface could give antimicrobial activity to them. Therefore, the antibacterial behavior and the hemotoxicity were analyzed against Gram-positive and Gram-negative bacteria and red blood cells, respectively.

Harnessing the power of polyol-based polyesters for biomedical innovations: synthesis, properties, and biodegradation

“…119,120 The mechanical properties and degradation rates of these polyesters can be tailored by varying the chain lengths in the dicarboxylate unit, making them suitable for a wide range of biomedical applications. 121 One key advantage of mannitol-based polyesters is their tunable mechanical properties. Regarding the application, these bioelastomers can be synthesized to possess specific characteristics by varying the curing conditions, monomer ratios, and other factors.…”