Photodynamic diagnosis – current tool in diagnosis of carcinoma in situ of the urinary bladder

Lipiński, Marek; Różański, Waldemar; Markowski, Michał Paweł

doi:10.5114/wo.2015.54391

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…From this review article, it can be concluded that most photodynamic MM research is centered around PSs for PDT applications. PDD has been thoroughly investigated as an early diagnostic tool for bladder cancer [28]. However, for other cancers such as MM, it still remains under-investigated.…”

Section: Discussionmentioning

confidence: 99%

“…PDD is a diagnostic tool that has been recommended by the European Association of Urology (EAU) to detect carcinoma in situ within the bladder [28]. PDD involves the administration of a photosensitizer (PS), which is a fluorophore drug that is non-toxic to cells, as well as able to specifically localize in tumor cells only [25].…”

Section: Photodynamic Diagnosis and Treatmentmentioning

confidence: 99%

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Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma

2019

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Metastatic melanoma (MM) has a poor prognosis and is attributed to late diagnoses only when metastases has already occurred. Thus, early diagnosis is crucial to improve its overall treatment efficacy. The standard diagnostic tools for MM are incisional biopsies and/or fine needle aspiration biopsies, while standard treatments involve surgery, chemotherapy, or irradiation therapy. The combination of photodynamic diagnosis (PDD) and therapy (PDT) utilizes a photosensitizer (PS) that, when excited by light of a low wavelength, can be used for fluorescent non-destructive diagnosis. However, when the same PS is activated at a higher wavelength of light, it can be cytotoxic and induce tumor destruction. This paper focuses on PS drugs that have been used for PDD as well as PDT treatment of MM. Furthermore, it emphasizes the need for continued investigation into enhanced PS delivery via active biomarkers and passive nanoparticle systems. This should improve PS drug absorption in MM cells and increase effectiveness of combinative photodynamic methods for the enhanced diagnosis and treatment of MM can become a reality.

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Section: Discussionmentioning

confidence: 99%

Section: Photodynamic Diagnosis and Treatmentmentioning

confidence: 99%

Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma

2019

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“…(Naidoo et al, 2019) Due to the induction of the production of fluorescent compounds, it is a very helpful tool to guide tumor' excision, while being non-invasive and extremely target-precise. Thought, PDT is not without limitations as it cannot be applied to patients with specific blood diseases (Krammer and Verwanger, 2016;Lipiński et al, 2015).…”

Section: Emerging Non-invasive Diagnostic Technologies For Skin Cancermentioning

confidence: 99%

Towards an Effective Imaging-Based Decision Support System for Skin Cancer

Vardasca

Magalhães

2022

Advances in Healthcare Information Systems and Administration

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The usage of expert systems to aid in medical decisions has been employed since 1980s in distinct applications. With the high demands of medical care and limited human resources, these technologies are required more than ever. Skin cancer has been one of the pathologies with higher growth, which suffers from lack of dermatology experts in most of the affected geographical areas. A permanent record of examination that can be further analyzed are medical imaging modalities. Most of these modalities were also assessed along with machine learning classification methods. It is the aim of this research to provide background information about skin cancer types, medical imaging modalities, data mining and machine learning methods, and their application on skin cancer imaging, as well as the disclosure of a proposal of a multi-imaging modality decision support system for skin cancer diagnosis and treatment assessment based in the most recent available technology. This is expected to be a reference for further implementation of imaging-based clinical support systems.

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“…[10][11][12][13][14][15] In patients with World Health Organization (WHO) grade 3 and 4 gliomas, 5-ALA has shown high positive predictive value for malignancy; furthermore, 5-ALA FGS increases rates of gross total resection, negative margins, and overall survival. 2,7 More recently, 5-ALA has been studied in a variety of other cancer types, including urothelial, 16 gastric, 17 prostate, 18 and ovarian 19 cancers.…”

Section: Introductionmentioning

confidence: 99%

5‐Aminolevulinic Acid Fluorescence‐Guided Surgery in Head and Neck Squamous Cell Carcinoma

et al. 2023

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ObjectivesTo determine the utility of 5‐aminolevulinic acid (5‐ALA) fluorescence for resection of head and neck carcinoma.MethodsIn this prospective pilot trial, 5‐ALA was administered as an oral suspension 3–5 h prior to induction of anesthesia for resection of head and neck squamous cell carcinoma (HNSCC). Following resection, 405 nm blue light was applied, and fluorescence of the tumor as well as the surgical bed was recorded. Specimen fluorescence intensity was graded categorically as none (score = 0), mild (1), moderate (2), or robust (3) by the operating surgeon intraoperatively and corroborated with final pathologic diagnosis.ResultsSeven patients underwent resection with 5‐ALA. Five (83%) were male with an age range of 33–82 years (mean = 60). Sites included nasal cavity (n = 3), oral cavity (n = 3), and the larynx (n = 1). All specimens demonstrated robust fluorescence when 5‐ALA was administered 3–5 h preoperatively. 5‐ALA fluorescence predicted the presence of perineural invasion, a positive margin, and metastatic lymphadenopathy. Two patients had acute photosensitivity reactions, and one patient had a temporary elevation of hepatic enzymes.Conclusions5‐ALA induces robust intraoperative fluorescence of HNSCC, capable of demonstrating a positive margin, perineural invasion, and metastatic nodal disease. Although no conclusions are there about the safety of this drug in the head and neck cancer population, our study parallels the extensive safety data in the neurosurgical literature. Future applications may include intraoperative assessment of margin status, diagnostic accuracy, and impacts on survival.Level of Evidence4 Laryngoscope, 2023

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Photodynamic diagnosis – current tool in diagnosis of carcinoma in situ of the urinary bladder

Cited by 5 publications

References 8 publications

Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma

Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma

Towards an Effective Imaging-Based Decision Support System for Skin Cancer

5‐Aminolevulinic Acid Fluorescence‐Guided Surgery in Head and Neck Squamous Cell Carcinoma

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