Photodynamic inactivation of Staphylococcus aureus by ecological antibacterial solutions associating LED (ʎ 450 ± 10 nm) with curcumin and olive leaf extracts

Crugeira, Pedro J.L.; Almeida, Heloísa H.S.; Teixeira, Liandra G.; Barreiro, María Filomena

doi:10.1016/j.jphotobiol.2022.112626

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…The chemical structures of polyphenols. However, the excellent biological and pharmacological activities of curcumin are hindered by its inherent physicochemical properties, including low solubility, rapid metabolization, instability, and the presence of a negative charge state, which hampers effective contact and adhesion to the surfaces of bacteria with negative charge (72). Extensive research has been conducted to address these challenges, particularly through the exploration of an ideal nanocarrier for curcumin (73-75).…”

Section: Curcuminmentioning

confidence: 99%

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Wang,

Fekrazad

et al. 2023

Front. Immunol.

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Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest developments and future implications of using natural polyphenols as PSs in aPDT. Paramount polyphenolic compounds, including curcumin, hypericin, quercetin, hypocrellin, celastrol, riboflavin, resveratrol, gallic acid, and aloe emodin, are elaborated upon with respect to their structural characteristics, absorption properties, and antimicrobial effects. Furthermore, the aPDT mechanism, specifically its targeted action on microbial cells and biofilms, is also discussed. Polyphenolic natural products demonstrate immense potential as PSs in aPDT, representing a promising alternate approach to counteract antibiotic-resistant bacteria and biofilm-related infections.

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Section: Curcuminmentioning

confidence: 99%

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Wang,

Fekrazad

et al. 2023

Front. Immunol.

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Porphyrinoid macrocycles as potential photosensitizers for photodynamic inhibition of biofilm formation in household water storage systems

Malomane,

Mlambo,

Kuvarega

et al. 2024

Int. J. Environ. Sci. Technol.

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The issue of biofilm formation by microorganisms in household water storage systems is a problem that lowers the efficiency of disinfectants. Antimicrobial photodynamic inactivation (aPDI) is a potential alternative to the current water disinfection methods. It employs a photosensitizer agent that inactivates microbes by absorbing light of a specific wavelength in the presence of molecular oxygen. Although aPDI has been proven in literature to have a wide spectrum of action, effective against resistant microbes and biofilms, it has not been approved for real-life applications yet. Therefore, there is an ongoing search for ideal photosensitizers that can produce sufficient reactive oxygen species for efficient inactivation of microbes and disruption of biofilms in household water storage systems. This review summarises the developments that have been made so far with porphyrin-, expanded porphyrin-, corrole-, and boron dipyrromethene-based photosensitizers. First, the issues with the current water disinfection methods are described, and then aPDI is also described as a possible alternative to the current methods. Emphasis is put on the antimicrobial activities and the solid support materials that the porphyrinoid family members have been incorporated into for potential application in the disinfection of household water and limitation of biofilm formation in water storage systems.

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Antimicrobial photodynamic therapy encapsulation technology: Frontier exploration and application prospects of novel antimicrobial technology

Hu,

Shou,

Yang

et al. 2023

Chemical Engineering Journal

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Photodynamic inactivation of Staphylococcus aureus by ecological antibacterial solutions associating LED (ʎ 450 ± 10 nm) with curcumin and olive leaf extracts

Cited by 4 publications

References 54 publications

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

Porphyrinoid macrocycles as potential photosensitizers for photodynamic inhibition of biofilm formation in household water storage systems

Antimicrobial photodynamic therapy encapsulation technology: Frontier exploration and application prospects of novel antimicrobial technology

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