Photodynamic therapy for peripheral lung cancer

Okunaka, Tetsuya; Kato, Harubumi; Tsutsui, Hidemitsu; Ishizumi, Taichirou; Ichinose, Shuji; Kuroiwa, Yukari

doi:10.1016/j.lungcan.2003.08.016

Cited by 73 publications

(33 citation statements)

References 19 publications

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“…Interventional pulmonology together with, for example, conformal stereotactic radiation [41], radiofrequency ablation [42] or transthoracic photodynamic therapy (PDT) [43], will provide a vast array of local treatment alternatives that are minimally invasive and should be diligently investigated. The issue of overdiagnosis and treatment of pseudo-diseases justifies an interventional approach fraught with lower morbidity and mortality for potentially malignant clonal cells that are being detected in increasing numbers [29][30][31].…”

Section: Nonsurgical Candidatesmentioning

confidence: 99%

Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Bolliger¹

2006

Eur Respir J

338

276

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Minimally invasive diagnostic and therapeutic approaches in medicine have been applied for a more selective and tailored approach to reduce patients' morbidity and mortality. The efficacy of interventional pulmonology for palliation of patients with central airways obstruction has been established and its curative potential for intralesional treatment of early cancer has raised great interest in current screening programmes. This is due to the fact that surgical resection and systemic nodal dissection as the gold standard is relatively morbid and risky, especially when dealing with individuals with limited functional reserves due to smoking-related comorbidities, such as chronic obstructive pulmonary disease. Furthermore, such comorbidities have been proven to harbour early stage lesions of several millimetres in size without involvement of nodal disease that may be amenable to local bronchoscopic treatment.Therefore, the success of minimally invasive strategies for palliation and treatment with curative intent strongly depends on the diligent identification of the various factors in lung cancer management, including full comprehension of the limits and potential of each particular technique. Maximal preservation of quality of life is a prerequisite in successfully dealing with individuals at risk of harbouring asymptomatic early lung cancer, to prevent aggressive surgical diagnostic and therapeutic strategies since overdiagnosis remains an issue that is heavily debated.In the palliative setting of alleviating central airway obstruction, laser resection, electrocautery, argon plasma coagulation and stenting are techniques that can provide immediate relief, in contrast to cryotherapy, brachytherapy and photodynamic therapy with delayed effects. With curative intent, intraluminal techniques that easily coagulate early stage cancer lesions will increase the implementation of interventional pulmonology for benign and relatively benign diseases, as well as early cancer lesions and its precursors at their earliest stage of disease.

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Section: Nonsurgical Candidatesmentioning

confidence: 99%

Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Bolliger¹

2006

Eur Respir J

338

276

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“…We initiated an experimental animal study of interstitial PDT for peripheral lung lesions by inserting an optical fiber into the tumor via a percutaneous needle [24]. In January 2001, we started a clinical trial of interstitial PDT for peripheral-type lung cancers, including primary and metastatic lung cancers [25]. Nine patients, who were unsuitable for surgery because of poor general physical conditions, were registered.…”

Section: Pdt For Peripheral Lung Cancermentioning

confidence: 99%

Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital

et al. 2006

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“…In such cases, the illumination is performed using imaging methods to localize the tumor. 63 An alternative method is to use a thoracoscope to visualize the tumor and place the light delivery fiber under direct vision.…”

Section: -62mentioning

confidence: 99%

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2015

Surg J

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Photodynamic therapy for peripheral lung cancer

Cited by 73 publications

References 19 publications

Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents

Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital

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