Photodynamic therapy using graphene quantum dot derivatives

Ahirwar, Satyaprakash; Mallick, Sudhanshu; Bahadur, D.

doi:10.1016/j.jssc.2019.121107

Cited by 49 publications

(30 citation statements)

References 36 publications

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“…8,9 Secondly, their high intensity and resistance towards photobleaching permit the longterm tracking of live, single-molecules, which offers detailed information on intracellular trafficking and processing. 10,11 QDs are also being extensively used in the development of anticancer interventions either directly for photodynamic [12][13][14][15] or photothermal [16][17][18] therapy applications, or in combination with existing drug formulations, 5,19,20 rendering them as promising theranostic agents.…”

Section: Introductionmentioning

confidence: 99%

A Multiparametric Evaluation of Quantum Dot Size and Surface-Grafted Peptide Density on Cellular Uptake and Cytotoxicity

et al. 2020

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Despite the progress in nanotechnology for biomedical applications, great efforts are still employed in optimizing nanoparticle (NP) design parameters to improve functionality and minimize bio-nanotoxicity. In this study, we developed CdSe/CdS/ZnS core/shell/shell quantum dots (QDs) that are compact ligandcoated and surface-functionalized with an HIV-1-derived TAT cell-penetrating peptide (CPP) analog to improve both biocompatibility and cellular uptake. Multiparametric studies were performed in different mammalian and murine cell lines to compare the effects of varying QD size and number of surface CPPs on cellular uptake, viability, generation of reactive oxygen species, mitochondrial health, cell area, and autophagy. Our results showed that the number of cell-associated NPs and their respective toxicity is higher for the larger QDs. Meanwhile, increasing the number of surface CPPs also enhanced cellular uptake and induced cytotoxicity through the generation of mitoROS and autophagy. Thus, here we report the optimal size and surface CPP combinations for improved QD cellular uptake.

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Section: Introductionmentioning

confidence: 99%

A Multiparametric Evaluation of Quantum Dot Size and Surface-Grafted Peptide Density on Cellular Uptake and Cytotoxicity

et al. 2020

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“…Therefore it is important not only to improve the characteristics of the NPs, but also to develop appropriate novel PS molecules [ 125 ]. To summarize, X-ray-activated NPs, quantum dots, two-photon-absorbing NPs, and up-conversion NPs could be included in this group (see Figure 1 C) [ 126 , 127 , 128 , 129 ].…”

Section: Nanoparticles—general Systematizationmentioning

confidence: 99%

Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer

et al. 2022

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It is more than sixty years since the era of modern photodynamic therapy (PDT) for cancer began. Enhanced selectivity for malignant cells with a reduced selectivity for non-malignant cells and good biocompatibility along with the limited occurrence of side effects are considered to be the most significant advantages of PDT in comparison with conventional therapeutic approaches, e.g., chemotherapy. The phenomenon of multidrug resistance, which is associated with drug efflux transporters, was originally identified in relation to the application of chemotherapy. Unfortunately, over the last thirty years, numerous papers have shown that many photosensitizers are the substrates of efflux transporters, significantly restricting the effectiveness of PDT. The concept of a dynamic nanoplatform offers a possible solution to minimize the multidrug resistance effect in cells affected by PDT. Indeed, recent findings have shown that the utilization of nanoparticles could significantly enhance the therapeutic efficacy of PDT. Additionally, multifunctional nanoplatforms could induce the synergistic effect of combined treatment regimens, such as PDT with chemotherapy. Moreover, the surface modifications that are associated with nanoparticle functionalization significantly improve the target potential of PDT or chemo-PDT in multidrug resistant and cancer stem cells.

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“…This is a common nanoscale modification of drug delivery that increases efficacy and benefits drug pharmacokinetics [ 247 ]. Moreover, PDT also uses nanotechnology where photosensitizers are modified by adding quantum dots to the system, which also seems to be a great solution [ 248 ]. It connects to a photosensitizer, and the task of quantum dots is to target and deliver photosensitizers directly to cells, providing additional enhancement in drug transport to the desired therapeutic area [ 249 ].…”

Section: Why Are Hyperthermia and Pdt Used In Treatment? Why Are They A Good Option For Combination Treatment?mentioning

confidence: 99%

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

et al. 2021

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Cancer is one of the leading causes of death in humans. Despite the progress in cancer treatment, and an increase in the effectiveness of diagnostic methods, cancer is still highly lethal and very difficult to treat in many cases. Combination therapy, in the context of cancer treatment, seems to be a promising option that may allow minimizing treatment side effects and may have a significant impact on the cure. It may also increase the effectiveness of anti-cancer therapies. Moreover, combination treatment can significantly increase delivery of drugs to cancerous tissues. Photodynamic therapy and hyperthermia seem to be ideal examples that prove the effectiveness of combination therapy. These two kinds of therapy can kill cancer cells through different mechanisms and activate various signaling pathways. Both PDT and hyperthermia play significant roles in the perfusion of a tumor and the network of blood vessels wrapped around it. The main goal of combination therapy is to combine separate mechanisms of action that will make cancer cells more sensitive to a given therapeutic agent. Such an approach in treatment may contribute toward increasing its effectiveness, optimizing the cancer treatment process in the future.

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Photodynamic therapy using graphene quantum dot derivatives

Cited by 49 publications

References 36 publications

A Multiparametric Evaluation of Quantum Dot Size and Surface-Grafted Peptide Density on Cellular Uptake and Cytotoxicity

A Multiparametric Evaluation of Quantum Dot Size and Surface-Grafted Peptide Density on Cellular Uptake and Cytotoxicity

Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer

Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

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