2019
DOI: 10.1002/jper.18-0305
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Photodynamic therapy versus systemic antibiotic for the treatment of periodontitis in a rat model

Abstract: Background: To compare the therapeutic effect of photodynamic therapy (PDT) with Toluidine blue O hydrogel versus systemic antibiotic (SA) in treating periodontitis on rats.Methods: Thirty-two Wistar rats were divided into four groups and treated differently: Negative control (NC) group, normal rats; positive control (PC) group, rats with periodontitis; SA group, rats with periodontitis treated with systemic antibiotic; PDT group, rats with periodontitis treated with PDT. After treatment, gingival sulcus bacte… Show more

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Cited by 10 publications
(5 citation statements)
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“…115 Compared with the systemic use of metronidazole, aPDT significantly lowered the bacterial load and IL-1β level of the gingival sulcus of rats with periodontitis. 116 These results suggest that aPDT has an anti-inflammatory effect on IL-1β.…”
Section: Antibioticsmentioning
confidence: 79%
“…115 Compared with the systemic use of metronidazole, aPDT significantly lowered the bacterial load and IL-1β level of the gingival sulcus of rats with periodontitis. 116 These results suggest that aPDT has an anti-inflammatory effect on IL-1β.…”
Section: Antibioticsmentioning
confidence: 79%
“…102 The APDT technique has been reported to be superior to the systemic antibiotic metronidazole in experimental animal models of periodontitis. 103 The technique showed comparable effects as SRP in terms of clinical parameters, 104 as well as the titer of tumor necrosis factor-alpha and receptor activator of nuclear factor-kappaB ligand (RANKL) in the gingival crevicular fluid of patients suffering from aggressive periodontitis. 105 A meta-analysis of four RCTs indicated that a combined therapy of SRP and APDT provided additional clinical improvement in the maintenance of residual pockets during supportive periodontal therapy.…”
Section: Antimicrobial Photodynamic Therapy (Apdt)mentioning
confidence: 95%
“… 1 By creating toxins and indirectly triggering the endogenous immune system, 2 , 3 large amounts of cytokines, including interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and other factors are released, resulting in localized periodontal tissue inflammation and ultimately the destruction of the tissue that supports the of teeth. 4 , 5 …”
Section: Introductionmentioning
confidence: 99%