Photoelectrochemical Immunosensor for Sensitive Quantification of Prostate Specific Antigen in Human Serum Samples Exploiting BaTiO₃−CdS

Abstract

A novel label‐free photoelectrochemical immunosensor was developed for the determination of prostate‐specific antigen (PSA) based on fluorine‐doped tin oxide (FTO) electrode modified with barium titanate and cadmium sulfide (BaTiO3−CdS/FTO). The photoelectrochemical current density of the BaTiO3 platform sensitized with CdS for the ascorbic acid (AA) donor molecule was higher than that observed in the absence of CdS. The BaTiO3−CdS/FTO platform was modified with PSA antibodies to produce the anti‐PSA/BaTiO3−CdS/FTO immunosensor, which was incubated in solutions of PSA to inhibit the photocurrent density of the immunosensor for AA. The photocurrent density of the anti‐PSA/BaTiO3−CdS/FTO immunosensor presented a linear relationship with the logarithm of the PSA concentration ranging from 1 pg mL−1 to 1 μg mL−1 with good sensitivity. The proposed method presented an experimental detection limit of 1 pg mL−1 (S/N=3). The immunosensor was successfully employed for the determination of PSA in blood serum samples, with recoveries between 98.7 %–104.4 %.

Thermal Excitation Polarized Field Drives Photoelectric Catalysis for Dye Degradation in a BaTiO3/CdS Heterojunction through Integration of Solar and Thermal Energy

“…Therefore, it has a strong attraction in degradation. In addition, compared with NHE, the CB side of CdS is more negative than that of BaTiO 3 , which matches well with the band position of BaTiO 3 , and improves the visible light absorption and inherent spontaneous polarization of BaTiO 3 [33] . One can expect to achieve enhanced photocatalytic performance by forming a heterojunction structure between BaTiO 3 and CdS.…”