Photoelectrochemical immunosensor for the sensitive detection of neuron-specific enolase based on the effect of Z-scheme WO3/NiCo2O4 nanoarrays p-n heterojunction

Zhang, Yingying; Wang, Tingting; Liu, De-Ling; Xu, Rui; Ma, Hongmin; Wei, Qin; Zhang, Yihe

doi:10.1016/j.bios.2022.114452

Cited by 18 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[9][10][11] Among these PTAs, gold (Au)-based nanomaterials play a critical role because of their localized surface plasmon resonance (LSPR) property. [12][13][14][15][16][17] A clinical study also reported that Au nanomaterial-mediated focal laser ablation was successful for 94% (15/16) of prostate cancer patients without serious complications or deleterious changes in genitourinary function. 18 Although the Au-based nanomaterials demonstrate an effective PTT approach, these nanomaterials still suffer from insufficient tumor accumulation because of their wide distribution in biosystems via metabolic processes, which lead to the induction of incomplete tumor elimination and unpredictable side effects in normal tissues and organs.…”

Section: Introductionmentioning

confidence: 96%

“…9 – 11 Among these PTAs, gold (Au)-based nanomaterials play a critical role because of their localized surface plasmon resonance (LSPR) property. 12 – 17 A clinical study also reported that Au nanomaterial-mediated focal laser ablation was successful for 94% (15/16) of prostate cancer patients without serious complications or deleterious changes in genitourinary function. 18 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

Chen

Huang

et al. 2023

Int J Oral Sci

View full text Add to dashboard Cite

Cancer cell membrane (CCM) derived nanotechnology functionalizes nanoparticles (NPs) to recognize homologous cells, exhibiting translational potential in accurate tumor therapy. However, these nanoplatforms are majorly generated from fixed cell lines and are typically evaluated in cell line-derived subcutaneous-xenografts (CDX), ignoring the tumor heterogeneity and differentiation from inter- and intra- individuals and microenvironments between heterotopic- and orthotopic-tumors, limiting the therapeutic efficiency of such nanoplatforms. Herein, various biomimetic nanoplatforms (CCM-modified gold@Carbon, i.e., Au@C-CCM) were fabricated by coating CCMs of head and neck squamous cell carcinoma (HNSCC) cell lines and patient-derived cells on the surface of Au@C NP. The generated Au@C-CCMs were evaluated on corresponding CDX, tongue orthotopic xenograft (TOX), immune-competent primary and distant tumor models, and patient-derived xenograft (PDX) models. The Au@C-CCM generates a photothermal conversion efficiency up to 44.2% for primary HNSCC therapy and induced immunotherapy to inhibit metastasis via photothermal therapy-induced immunogenic cell death. The homologous CCM endowed the nanoplatforms with optimal targeting properties for the highest therapeutic efficiency, far above those with mismatched CCMs, resulting in distinct tumor ablation and tumor growth inhibition in all four models. This work reinforces the feasibility of biomimetic NPs combining modular designed CMs and functional cores for customized treatment of HNSCC, can be further extended to other malignant tumors therapy.

show abstract

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

Chen

Huang

et al. 2023

Int J Oral Sci

View full text Add to dashboard Cite

show abstract

“…When the sensor is used for the detection of NSE, it has a good linear relationship in the range of 0.1–1000 ng/mL, and the detection limit is 0.05 ng/mL. Comparatively, Zhang et al’s photoelectrochemical immunosensor based on a Z-scheme WO 3 /NiCo 2 O 4 nanoarray p-n heterojunction utilizes the LSPR effect of Au to convert thermions into a photocurrent to achieve signal amplification [ 33 ]. As a representative spinel-type binary metal oxide, NiCo 2 O 4 has good electrical conductivity, and WO 3 /NiCo 2 O 4 with a large specific surface area provides a large number of active centers for the loading of polydopamine (PDA) films.…”

Section: Application Of Biosensor In Detection Of Tumor Biomarkersmentioning

confidence: 99%

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Jiang

Xue

et al. 2022

Molecules

View full text Add to dashboard Cite

Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed.

show abstract

“…To date, because of the good specificity, there are various immunoassay methods developed for NSE determination, such as enzyme-linked immunosorbent assay, 9 fluorescence immunoassay, 10 electrochemical immunoassay, 11,12 electrochemiluminescent immunoassay, 13 colorimetric immunoassay, 14,15 photoelectrochemical (PEC) immunoassay, 16,17 and so on. Among them, PEC immunoassay possesses excellent features, such as low background signal, desirable sensitivity, rapid test, simple operation, and so forth.…”

Section: Introductionmentioning

confidence: 99%

“…To date, because of the good specificity, there are various immunoassay methods developed for NSE determination, such as enzyme-linked immunosorbent assay, fluorescence immunoassay, electrochemical immunoassay, , electrochemiluminescent immunoassay, colorimetric immunoassay, , photoelectrochemical (PEC) immunoassay, , and so on. Among them, PEC immunoassay possesses excellent features, such as low background signal, desirable sensitivity, rapid test, simple operation, and so forth. − However, the immune reaction, which is carried out directly on the photoelectrode, has some uncertainties, for example, the substrate material will affect the activity of the immune substance, which will further affect the reproducibility and stability of the sensor .…”

Section: Introductionmentioning

confidence: 99%

Split-Type Photoelectrochemical/Visual Sensing Platform Based on SnO₂/MgIn₂S₄/Zn_0.1Cd_0.9S Composites and Au@Fe₃O₄ Nanoparticles for Ultrasensitive Detection of Neuron Specific Enolase

Leng

Wang

et al. 2022

Anal. Chem.

Self Cite

View full text Add to dashboard Cite

Herein, a novel dual mode detection system of split-type photoelectrochemical (PEC) and visual immunoassay was developed to detect neuron specific enolase (NSE), which achieved simultaneous and reliable NSE detection due to the completely different signal readouts and transduction mechanism. Specifically, specific reactions of antigens and antibodies were performed in 96-microwell plates. Gold nanoparticle (Au NP)-loaded Fe3O4 (Au@Fe3O4) NPs were used as secondary antibody markers and signal regulators, which could produce a blue-colored solution in the presence of 3,3′,5,5′-tetramethylbenzidine (TMB) and H2O2 because of its peroxidase-like activity. Therefore, the visual detection of NSE was realized, making the results more intuitive. Meanwhile, the above biological process could also be used as part of the split-type PEC sensing platform. Oxidized TMB and Fe3+ were consumptive agents of the electron donor, which both realized the double quenching of PEC signal generated by the SnO2/MgIn2S4/Zn0.1Cd0.9S composites. Owing to the waterfall band structure, SnO2/MgIn2S4/Zn0.1Cd0.9S composites partially absorb visible light and effectively inhibit the electron–hole recombination, thereby providing significantly enhanced and stable initial signal. On the basis of the multiple signal amplification strategy and the split-type mode, NSE could be sensitively detected with a low detection limit of 14.0 fg·mL–1 (S/N = 3) and a wide linear range from 50.0 fg·mL–1 to 50.0 ng·mL–1.

show abstract

Photoelectrochemical immunosensor for the sensitive detection of neuron-specific enolase based on the effect of Z-scheme WO3/NiCo2O4 nanoarrays p-n heterojunction

Cited by 18 publications

References 30 publications

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Split-Type Photoelectrochemical/Visual Sensing Platform Based on SnO₂/MgIn₂S₄/Zn_0.1Cd_0.9S Composites and Au@Fe₃O₄ Nanoparticles for Ultrasensitive Detection of Neuron Specific Enolase

Contact Info

Product

Resources

About

Photoelectrochemical immunosensor for the sensitive detection of neuron-specific enolase based on the effect of Z-scheme WO3/NiCo2O4 nanoarrays p-n heterojunction

Cited by 18 publications

References 30 publications

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Split-Type Photoelectrochemical/Visual Sensing Platform Based on SnO2/MgIn2S4/Zn0.1Cd0.9S Composites and Au@Fe3O4 Nanoparticles for Ultrasensitive Detection of Neuron Specific Enolase

Contact Info

Product

Resources

About

Split-Type Photoelectrochemical/Visual Sensing Platform Based on SnO₂/MgIn₂S₄/Zn_0.1Cd_0.9S Composites and Au@Fe₃O₄ Nanoparticles for Ultrasensitive Detection of Neuron Specific Enolase