Photofunctionalization Enhances Bone-Implant Contact, Dynamics of Interfacial Osteogenesis, Marginal Bone Seal, and Removal Torque Value of Implants

Pyo, Se-Wook; Park, Young Bum; Moon, Hi-Soo; Lee, Jae Hoon; Ogawa, Takahiro

doi:10.1097/id.0000000000000003

Cited by 36 publications

(32 citation statements)

References 30 publications

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“…All implants placed in tibias and femurs were unloaded. In detail, most authors reported significantly increased BIC [57,71,[73][74][75][76][77][78][79], push-in values [40,44,[80][81][82][83], bone volume [72,84], or bone mineral [85,86] were noted in all animal models studied for photofunctionalized groups disregarding implant surface modifications/topography. The differences were insignificant for both UV-treated and non-UV-treated reported in four animal studies [87][88][89][90].…”

Section: Resultsmentioning

confidence: 99%

An Integrated Overview of Ultraviolet Technology for Reversing Titanium Dental Implant Degradation: Mechanism of Reaction and Effectivity

et al. 2020

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Titanium is widely used as an implanted material in various clinical applications, especially in orthopedics and dental implantology. Following manufacturing and storage, titanium dental implants have the ability to undergo aging, which renders a reduction in osteoblast cellular activity during the healing process, so advancement of a surface treatment to recreate bioactive implant surfaces are required. Ultra-violet (UV) surface treatment has been introduced as a potential solution to reverse the aging process via removal of hydrocarbon contamination on the surface. This narrative review aimed to discuss the current understanding of the mechanism of titanium aging and provide insights into the mechanism that improves the biocompatibility of titanium implants following UV treatment. Additionally, the findings from preclinical and clinical studies is integratively presented. A reference search was performed through the PubMed, Embase, and Scopus databases based on the keywords titanium degradation, titanium aging, photofunctionalization, and UV treatment. Emerging data demonstrated the positive effect of UV light on osteoblast cells with enhanced alkaline phosphatase activity in vitro and increased bone-implant contact in animal studies. Despite limited human studies, the data reported here appear to support the benefit of UV light photofunctionalization on titanium surfaces as an alternative to reverse the titanium aging process. The direction of future research should focus on prospective randomized blinded clinical trials.

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Section: Resultsmentioning

confidence: 99%

An Integrated Overview of Ultraviolet Technology for Reversing Titanium Dental Implant Degradation: Mechanism of Reaction and Effectivity

et al. 2020

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“…22 Photofunctionalisation enhances osteogenesis around the implant, increases interfacial bone deposition on Ti, and improves the marginal bone seal and support. 23 It has been suggested that photofunctionalisation induces denser cortical bone formation and a stiffer bone connection compared with control implants. 22 …”

Section: Discussionmentioning

confidence: 99%

Photofunctionalised Ti6Al4V implants enhance early phase osseointegration

Yamauchi

Itabashi²,

Wada

et al. 2017

Bone & Joint Research

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ObjectivesUltraviolet (UV) light-mediated photofunctionalisation is known to improve osseointegration of pure titanium (Ti). However, histological examination of titanium alloy (Ti6Al4V), which is frequently applied in orthopaedic and dental surgery, has not yet been performed. This study examined the osseointegration of photofunctionalised Ti6Al4V implants.MethodsTi and Ti6Al4V implants were treated with UV light, and the chemical composition and contact angle on the surfaces were evaluated to confirm photofunctionalisation. The implants were inserted into femurs in rats, and the rats were killed two or four weeks after the surgery. For histomorphometric analysis, both the bone–implant contact (BIC) ratio and the bone volume (BV) ratio were calculated from histological analysis and microcomputed tomography data.ResultsThe amount of carbon and the contact angle on both implants were significantly reduced after UV irradiation. The BIC ratios for both UV light-treated implants significantly increased at two weeks, but there was no significant difference at four weeks. There was no significant difference in the BV ratios between the UV light-treated and control implants at two or four weeks.ConclusionsThis study suggests that photofunctionalisation of Ti6Al4V implants, similar to that of Ti implants, may promotes osseointegration in early but not in the late phase of osseointegration.Cite this article: R. Yamauchi, T. Itabashi, K. Wada, T. Tanaka, G. Kumagai, Y. Ishibashi. Photofunctionalised Ti6Al4V implants enhance early phase osseointegration. Bone Joint Res 2017;6:331–336. DOI: 10.1302/2046-3758.65.BJR-2016-0221.R1.

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“…In terms of BIC assessment, photofunctionalization improved bone-to-implant contact in the initial healing period with statistically significant differences at 2 and 4 weeks of follow-up, regardless of the animal model used (Kim et al, 2016;Park et al, 2013;Pyo, Park, Moon, Lee, & Ogawa, 2013;Sawase et al, 2007;Takahashi et al, 2016;Yamauchi et al, 2017). In contrast, 12 weeks after implant placement, there were no differences between and among the groups (Kim et al, 2016;Park et al, 2013).…”

Section: F I G U R Ementioning

confidence: 88%

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Dini

Nagay

Magno

et al. 2020

Clinical Oral Implants Res

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Objectives To determine whether photofunctionalization influences dental implant osseointegration. Material and methods Data on osseointegration rates were extracted from 8 databases, based on bone‐to‐implant contact (BIC) and pushout tests. Internal validity was accessed through the SYRCLE risk of bias tool for animal experimental studies. Meta‐analyses were performed for investigation of the influence of photofunctionalization on implant osseointegration, with a random effect and a confidence interval of 95%. The certainty of evidence was accessed through the GRADE approach. Results Thirty‐four records were identified, and 10 were included in the meta‐analysis. Photofunctionalized implants showed higher mean values for BIC in rabbits (MD 6.92 [1.01, 12.82], p = .02), dogs (MD 23.70 [10.23, 37.16], p = .001), rats (MD 20.93 [12.91, 28.95], p < .0001), and in the pooled BIC analyses (MD 14.23 [7.80, 20.66], p < .0001) compared to those in control implants in the overall assay. Conversely, at late healing periods, the pooled BIC meta‐analyses showed no statistically significant differences (p > .05) for photofunctionalized and control implants at 12 weeks of follow‐up. For pushout analysis, photofunctionalized implants presented greater bone strength integration (MD 19.92 [13.88, 25.96], p < .0001) compared to that of control implants. The heterogeneity between studies ranged from “not important” to “moderate” for rabbits I2 = 24%, dogs I2 = 0%, rats I2 = 0%, and pooled BIC (I2 = 49%), while considerable heterogeneity was observed for pushouts (I2 = 90%). Conclusion Photofunctionalization improves osseointegration in the initial healing period of implants, as summarized from available data from rabbit, dog, and rat in vivo models.

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Photofunctionalization Enhances Bone-Implant Contact, Dynamics of Interfacial Osteogenesis, Marginal Bone Seal, and Removal Torque Value of Implants

Abstract: Photofunctionalization enhanced the morphology, quality, and behavior of periimplant osteogenesis, including the increased BIC, expedited robust interfacial bone deposition, and improved marginal bone seal and support.

Cited by 36 publications

References 30 publications

An Integrated Overview of Ultraviolet Technology for Reversing Titanium Dental Implant Degradation: Mechanism of Reaction and Effectivity

An Integrated Overview of Ultraviolet Technology for Reversing Titanium Dental Implant Degradation: Mechanism of Reaction and Effectivity

Photofunctionalised Ti6Al4V implants enhance early phase osseointegration

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

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