2014
DOI: 10.1016/j.det.2014.03.005
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Photoimmunology

Abstract: SYNOPSIS The discipline that investigates the biological effects of ultraviolet radiation on the immune system is called photoimmunology. Photoimmunology evolved from an interest in understanding the role of the immune system in skin cancer development, and why immunosuppressed organ transplant recipients are at greatly increased risk for cutaneous neoplasms. Ultraviolet radiation-induced damage DNA modifies the antigen presenting function of cutaneous dendritic cells, biases the immune response towards the ge… Show more

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Cited by 39 publications
(44 citation statements)
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References 108 publications
(100 reference statements)
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“…[26][27][28] Immunosuppression Photoimmunology is the field of photodermatology that explores the complex relationship between UVR and the immune system. 29 Direct evidence that UVR acts as an immunosuppressant derives from a classic series of experiments in mice showing that UVR prevents the immunologic rejection and eradication of highly immunogenic transplanted UV-induced skin tumors. 30,31 The immunosuppressive effects of UVR are mostly due to the medium wavelengths (UVB), but the long wavelengths (UVA) also influence immune reactions.…”
Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning
confidence: 99%
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“…[26][27][28] Immunosuppression Photoimmunology is the field of photodermatology that explores the complex relationship between UVR and the immune system. 29 Direct evidence that UVR acts as an immunosuppressant derives from a classic series of experiments in mice showing that UVR prevents the immunologic rejection and eradication of highly immunogenic transplanted UV-induced skin tumors. 30,31 The immunosuppressive effects of UVR are mostly due to the medium wavelengths (UVB), but the long wavelengths (UVA) also influence immune reactions.…”
Section: Beyond Dna Mutagenesis: Damage Of Other Molecular Targetsmentioning
confidence: 99%
“…23,29,32,33,35 Topically applied exogenous DNA repair enzymes can prevent the immune system suppression induced by UVR. 36 UVR also affects cytoplasmic and membrane targets acting as additional photoreceptors for UVR-induced immunosuppression.…”
Section: Molecular Targetsmentioning
confidence: 99%
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