Photoluminescence in the characterization and early detection of biomimetic bone-like apatite formation on the surface of alkaline-treated titanium implant: State of the art

Sepahvandi, Azadeh; Moztarzadeh, F.; Mozafari, Masoud; Ghaffari, Maryam; Raee, Nahid

doi:10.1016/j.colsurfb.2011.04.027

Cited by 41 publications

(8 citation statements)

References 40 publications

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“…3 The newly formed apatite, together with the adsorption of biological moieties, constitutes an excellent layer for the action of osteoblasts and subsequent bone-implant xation. 4 Thus far, a variety of biocomposites of bioceramics (or bioglasses, etc.) and polymers have shown differing degrees of success as bone regeneration materials.…”

Section: Introductionmentioning

confidence: 99%

Development of a bioactive composite of nano fluorapatite and poly(butylene succinate) for bone tissue regeneration

et al. 2014

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The development of a bioactive nanocomposite for bone replacement has gained much interest in the field of bone grafting. In this study, a nano fluorapatite (n-FA)-poly(butylene succinate) (PBS) bioactive composite was fabricated using a co-solution method. The results showed that the n-FA-PBS composite had improved hydrophilicity, compressive strength and an elastic modulus, which were obviously higher than those of PBS alone. In addition, the n-FA-PBS composite could inhibit bacterial attachment, with the number of viable bacteria on the composite obviously lower than on pure PBS, indicating good antibacterial ability. Moreover, the attachment and proliferation of human mesenchymal stem cells (hMSCs) on the n-FA-PBS composite was significantly higher than on PBS, and the alkaline phosphatase (ALP) activity of hMSCs on the composite was expressed at significantly higher levels compared to PBS. Furthermore, the hMSCs showed intimate contact with the composite surface and the cells spread and grew significantly better on the composite compared to PBS. Therefore, incorporation of n-FA into PBS is a good way to prepare an inorganic-organic bioactive composite of a nano ceramic and a polymer, which supports cell attachment, proliferation and differentiation. The implantation of the n-FA-PBS composite into the femoral bone of rabbits confirmed that the new bone tissue could form on the composite surfaces, and the composite combined directly with the natural bone tissue without fibrous capsule tissue, showing good osteoconductivity. In short, the n-FA-PBS bioactive composite has good biocompatibility and bioactivity, and has potential application in bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Development of a bioactive composite of nano fluorapatite and poly(butylene succinate) for bone tissue regeneration

et al. 2014

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“…Because of its excellent biocompatibility and bioactivity, hydroxyapatite (HA) has been always considered for bone or dental applications . HA composition is similar to the mineral part of natural bones and teeth.…”

Section: Introductionmentioning

confidence: 99%

Characteristics improvement of calcium hydroxide dental cement by hydroxyapatite nanoparticles. Part 1: Formulation and microstructure

Yasaei

Zamanian

Moztarzadeh

et al. 2013

Biotech and App Biochem

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Calcium hydroxide cement (CHC), which is a direct pulp-capping material, has been widely used for several decades. In spite of the well-known advantages of CHCs, they have some disadvantages as well, such as high solubility, no inherent adhesive qualities, and low mechanical strength. Previous studies were undertaken to improve these deficiencies by implementing changes to modify the conventional CHCs. The aim of the present research is to demonstrate the potential rectification of the aforementioned deficiencies of the commercially available CHCs by adding hydroxyapatite (HA) nanoparticles without lessening their advantages. Here, the synthesized HA nanoparticles were added into the CHCs in two different portions of 3 and 7 wt%. A scanning electron microscope was used to observe and analyze the microstructure, and X-ray energy dispersive analysis was used to analyze the elemental composition of the new CHCs. In addition, setting time, mechanical strength, pH, calcium (Ca) release, and antibacterial behavior were measured to assess how HA nanoparticles influence the characteristics of CHCs. The results showed that adding 3 wt% HA nanoparticles can optimally improve the mechanical strength of the cement and increase the Ca release rate as a mineralization promoter without reducing the antibacterial behavior.

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“…It is well known that a certain concentration of calcium and phosphorus ions generate insoluble compounds CaHPO 4 , Ca 3 (PO 4 ) 2 and Ca 10 (PO 4 ) 6 (OH) 2 by interaction, which reduces the concentration of calcium and phosphorus ions in the electrolyte. X. Zhao, L. Yang, Y. Zuo et al 15) showed that pH value of the electrolyte has an obvious effect on the solubility of the insoluble CaHPO 4 , Ca 3 (PO 4 ) 2 and Ca 10 -(PO 4 ) 6 (OH) 2 compounds.…”

Section: )mentioning

confidence: 99%

“…Hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) is an important biological ceramic material. Unfortunately, its applications are limited just because of its weakness, such as hydroxyapatite is brittle and its mechanical strength is low.…”

Section: Introductionmentioning

confidence: 99%

“…Titanium alloys present excellent corrosion resistance, mechanical performance and biocompatibility. 1,2) Therefore, investigations to prepare hydroxyapatite on the surface of titanium alloys have became one of the hotspots in biological materials, which take advantage of superior biocompatibility of HA without sacrificing mechanical properties of the titanium alloys.…”

Section: Introductionmentioning

confidence: 99%

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Influences of pH Value and Deposition Time on HA/TiO<sub>2</sub> Coatings Deposited by Electrochemical Method

Liu

et al. 2014

Mater. Trans.

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With titanium alloy after micro-arc oxidation as substrate, HA/TiO 2 coatings were prepared by electrochemical method. The coatings were characterized by means of SEM and XRD. Variation of pH value of electrode/electrolyte was measured by means of pH microprobe during treatment, and the influences of pH value and deposition time on HA/coatings by this method were investigated. The results show that micro-arc oxidation treatment are helpful to obtain a good adhesion between HA and substrate, and HA crystals are well-distributed on the TiO 2 film surface. The increasing of the pH value of treatment solutions results in higher crystallinity of HA crystals. During the process of deposition, pH value on the surface of the electrode increases at first and then decreases with deposition time, but pH value of electrolyte decreases with the deposition time. pH value has obvious influence on the morphology of HA crystals, and the size of HA crystal increases with the deposition time within certain limits. However, the size of HA crystal is abnormally large if the deposition time is too long.

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Photoluminescence in the characterization and early detection of biomimetic bone-like apatite formation on the surface of alkaline-treated titanium implant: State of the art

Cited by 41 publications

References 40 publications

Development of a bioactive composite of nano fluorapatite and poly(butylene succinate) for bone tissue regeneration

Development of a bioactive composite of nano fluorapatite and poly(butylene succinate) for bone tissue regeneration

Characteristics improvement of calcium hydroxide dental cement by hydroxyapatite nanoparticles. Part 1: Formulation and microstructure

Influences of pH Value and Deposition Time on HA/TiO<sub>2</sub> Coatings Deposited by Electrochemical Method

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