Photonic crystal surface mode imaging biosensor based on wavelength interrogation of resonance peak

Konopsky, Valery N.; Alieva, E. V.

doi:10.1016/j.snb.2018.08.101

Cited by 14 publications

(16 citation statements)

References 21 publications

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“…[ 133,134,143 ] Other than diffraction gratings, 1D PhCs can be constructed in a vertical form by depositing a stack of periodically spaced high‐index and low‐index (e.g., TiO 2 /SiO 2 ) layers on a plate substrate. [ 136,137 ] Cunningham et al. pioneered the field and termed the technology “photonic crystal enhanced microscopy” (PCEM).…”

Section: Imaging Based On On‐chip Nanostructuresmentioning

confidence: 99%

Refractometric Imaging and Biodetection Empowered by Nanophotonics

Geng

Shum

et al. 2023

Laser & Photonics Reviews

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Advancing clinical and nonclinical diagnostic technologies is particularly crucial for improved preparedness for the next pandemic and other global healthcare challenges. To this end, marrying advanced microscopic imaging with chip‐scale bioanalytical systems provides fresh modalities by analyzing signals of transmitted, reflected, or scattered light waves. This review brings clarity to the latest progress of refractometric imaging and biodetections on a chip, in which interferences and resonances as cornerstones of optics and plasmonics are breaking new ground. A vast range of nanophotonic and plasmonic transducers are discussed, ranging from planar films, nanoarrays, and waveguiding resonators to holistic designs. The augmented bioanalyses cover immunoassays, single‐molecule analysis, and motion tracking of bacterial pathogens and cells. Compared to single‐point spectroscopic measurements, imaging‐empowered approaches are rapidly evolving with greatly promoted signal‐noise ratio, spatial‐temporal resolutions, multiplexability, and throughput, which can be accomplished in a compact cradle system with minimized bulky components in a spectrometer‐free manner. Besides, advances in machine learning technologies applied for data analytics and transducer designs are highlighted. All in all, there are unlimited opportunities for new optical structures, principles, and ways of data retrieval to tap in, which will raise technological impacts on unveiling fundamental issues in life science and advancing global healthcare technologies.

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Section: Imaging Based On On‐chip Nanostructuresmentioning

confidence: 99%

Refractometric Imaging and Biodetection Empowered by Nanophotonics

Geng

Shum

et al. 2023

Laser & Photonics Reviews

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“…Similar hotspot mechanisms have been studied in the context of enhanced fluorescence and Raman scattering [19,21,22]. Carefully designed nanostructured substrates have also received significant attention [23,24], whereby coupling of different nanostructures can augment any perturbation upon addition of an analyte particle. Randomly distributed nanostructures are also known to give rise to a rich set of multiple scattering phenomena not seen in deterministic structures, such as Anderson localisation and long range correlations [25][26][27][28], which can aid single particle detection.…”

mentioning

confidence: 90%

Theory of Multiple Scattering Enhanced Single Particle Plasmonic Sensing

Berk,

Foreman

2021

Preprint

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Methods to increase the light scattered from small particles can help improve the sensitivity of many sensing techniques. Here, we investigate the role multiple scattering plays in perturbing the scattered signal when a particle is added to a random scattering environment. Three enhancement factors, parametrising the effect of different classes of multiple scattering trajectories on the field perturbation, are introduced and their mean amplitudes explored numerically in the context of surface plasmon polariton scattering. We demonstrate that there exists an optimum scatterer density at which the sensitivity enhancement is maximised, with factors on the order of 10 2 achievable. Dependence of the enhancement factors on scatterer properties are also studied.

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“…PC-based imaging sensors are characterized by a longer surface wave propagation and finer spatial resolution resulting in a higher sensitivity compared to the SPR-based approach [3]. Twodimensional (2D) imaging of binding events at the PC sensor surface with a picometer resolution, which provides them with the clear comparative advantages against the similar SPR imaging techniques, has been presented earlier [4].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Multiplexed Analysis Using Photonic Crystal-Based Biosensors

Nifontova

Fleury²,

Nabiev³

et al. 2022

J. Phys.: Conf. Ser.

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Label-free bioanalytical methods have been widely employed in biomedical research, in particular, in drug screening and discovery, diagnostics, and proteomics. Photonic crystals (PCs) represent a modern alternative to surface plasmon resonance (SPR) techniques. Imaging of PC surface modes has been demonstrated as a promising label-free approach allowing for multiplexed detection. Surface modification of PC sensors is an important stage determining the effectiveness of the analysis of biomolecule interactions. Here, we describe the results of the development of a label-free PC-based sensor, the key steps of the modification and functionalization of the PC surface with proteins, as well as the evaluation of its suitability for sensing via 2D imaging of binding events. Our data demonstrate the efficiency of the designed PC-based sensor for analysis of proteins interactions and pave the way for the engineering of a label-free biosensing platform based on PCs.

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Photonic crystal surface mode imaging biosensor based on wavelength interrogation of resonance peak

Cited by 14 publications

References 21 publications

Refractometric Imaging and Biodetection Empowered by Nanophotonics

Refractometric Imaging and Biodetection Empowered by Nanophotonics

Theory of Multiple Scattering Enhanced Single Particle Plasmonic Sensing

Label-Free Multiplexed Analysis Using Photonic Crystal-Based Biosensors

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