Photons or Protons: Precision Radiotherapy of Lung Cancer

Allmendinger, Thomas; Seydl, Karl; Futschek, Tanja; Sztankay, A.; Sweeney, Reinhart A.; Lukáš, Peter

doi:10.1007/s00066-007-2002-9

Cited by 19 publications

(17 citation statements)

References 26 publications

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“…Compared with the dummy plans for conventional photon 3D-CRT, our data demonstrated that PBT could reduce the doses to several OARs such as the lung and heart; these results are similar to those of previous reports (15)(16)(17). Chang et al compared the DVH parameters between PBT and 3DCRT/IMRT in 26 patients with stage III NSCLC.…”

Section: Discussionsupporting

confidence: 81%

Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced non-small cell lung cancer

Motegi

et al. 2016

Jpn. J. Clin. Oncol.

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Objective: To assess the feasibility of proton beam therapy for the patients with locally advanced non-small lung cancer. Methods: The dosimetry was analyzed retrospectively to calculate the doses to organs at risk, such as the lung, heart, esophagus and spinal cord. A dosimetric comparison between proton beam therapy and dummy photon radiotherapy (three-dimensional conformal radiotherapy) plans was performed. Dummy intensity-modulated radiotherapy plans were also generated for the patients for whom curative three-dimensional conformal radiotherapy plans could not be generated. Results: Overall, 33 patients with stage III non-small cell lung cancer were treated with proton beam therapy between December 2011 and August 2014. The median age of the eligible patients was 67 years (range: 44-87 years). All the patients were treated with chemotherapy consisting of cisplatin/vinorelbine or carboplatin. The median prescribed dose was 60 GyE (range: 60-66 GyE). The mean normal lung V20 GyE was 23.6% (range: 14.9-32%), and the mean normal lung dose was 11.9 GyE (range: 6.0-19 GyE). The mean esophageal V50 GyE was 25.5% (range: 0.01-63.6%), the mean heart V40 GyE was 13.4% (range: 1.4-29.3%) and the mean maximum spinal cord dose was 40.7 GyE (range: 22.9-48 GyE). Based on dummy three-dimensional conformal radiotherapy planning, 12 patients were regarded as not being suitable for radical thoracic three-dimensional conformal radiotherapy. All the dose parameters of proton beam therapy, except for the esophageal dose, were lower than those for the dummy three-dimensional conformal radiotherapy plans. In comparison to the intensity-modulated radiotherapy plan, proton beam therapy also achieved dose reduction in the normal lung. None of the patients experienced grade 4 or worse non-hematological toxicities. Conclusions: Proton beam therapy for patients with stage III non-small cell lung cancer was feasible and was superior to three-dimensional conformal radiotherapy for several dosimetric parameters.

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Section: Discussionsupporting

confidence: 81%

Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced non-small cell lung cancer

Motegi

et al. 2016

Jpn. J. Clin. Oncol.

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“…PBT holds advantage over 3D-CRT [1] when treating a tumor located close to critical organs, such as heart, esophagus, and spinal cord, since the major feature of PBT is the depth dose distribution. Timmerman et al [27] have shown that patients with central tumor locations have an elevenfold increase in risk of experiencing severe toxicity compared with those with more peripheral ones.…”

Section: Discussionmentioning

confidence: 99%

Comparisons of Dose-Volume Histograms for Proton-Beam versus 3-D Conformal X-Ray Therapy in Patients with Stage I Non-Small Cell Lung Cancer

et al. 2009

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“…There is much room for improvement of the above results, prompting investigation of new therapies, such as surgery plus brachytherapy [8,18], high-total-dose proton therapy (HDPT) [2], accelerated radiotherapy with or without chemotherapy [4,35,44], and stereotactic single high-dose irradiation of lung tumors under respiratory gating [15].…”

Section: Discussionmentioning

confidence: 99%

Hypofractionated Conformal Radiotherapy (HCRT) for Primary and Metastatic Lung Cancers with Small Dimension

et al. 2009

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Photons or Protons: Precision Radiotherapy of Lung Cancer

Cited by 19 publications

References 26 publications

Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced non-small cell lung cancer

Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced non-small cell lung cancer

Comparisons of Dose-Volume Histograms for Proton-Beam versus 3-D Conformal X-Ray Therapy in Patients with Stage I Non-Small Cell Lung Cancer

Hypofractionated Conformal Radiotherapy (HCRT) for Primary and Metastatic Lung Cancers with Small Dimension

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