Photonuclear production and radiochemical separation of medically relevant radionuclides: 67Cu

Алиев, Р. А.; Белышев, С. С.; Кузнецов, А. А.; Dzhilavyan, L. Z.; Khankin, V. V.; Aleshin, Gleb Yu.; Kazakov, Andrey G.; Priselkova, Anna B.; Kalmykov, Stepan N.; Ishkhanov, B. S.

doi:10.1007/s10967-019-06576-9

Cited by 24 publications

(11 citation statements)

References 45 publications

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“…Cu was produced according to the 64 Ni(p,n) 64 Cu reaction [42] from nickel metal target (0.5 g) of a natural isotopic composition using an 8-MeV proton beam at 1 μA for 3.5 h. Separation was performed on Cu-Resin (Triskem), as previously described. [43]…”

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confidence: 99%

Comparative Study of Macrocyclic and Acyclic Picolinate Derivatives for Chelation of Copper Cations

et al. 2021

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In this work we presented a synthesis and investigation of relative acyclic and macrocyclic polyamines with picolinate pendant arms as potential chelators for copper radiopharmaceuticals. It has been shown that linear chelators lacking bisamide moiety are much more basic and form complexes with higher stability constants compared to macrocyclic ones. Both types of ligands possess many donor sites due to picolinate groups enabling formation of polynuclear complexes in the solution and solid state. According to crystal structures metal cations coordinates with studied ligands through the binding with aminogroups and picolinates donor atoms, while terminal aminogroups of acyclic ligands do not take part in the complex formation. Tripicolinate azacrown ligand coordinates cations outside the macrocyclic cavity in non-equivalent positions. However this out-cage location as well as a moderate logK value do not induce fast release of cation from this complex in the challenging medium of serum proteins.

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Comparative Study of Macrocyclic and Acyclic Picolinate Derivatives for Chelation of Copper Cations

et al. 2021

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“…The photonuclear production for 67 Cu using bremsstrahlung photons with an e-LINAC accelerator has been studied for decades [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Recently, a large enriched 68 Zn target (55.5 g) was irradiated with 40 MeV e-LINAC for 53.5 h, obtaining 62.9 GBq (1.7 Ci) without detecting 64 Cu [ 10 ].…”

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confidence: 99%

67Cu Production Capabilities: A Mini Review

et al. 2022

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Is the 67Cu production worldwide feasible for expanding preclinical and clinical studies? How can we face the ingrowing demands of this emerging and promising theranostic radionuclide for personalized therapies? This review looks at the different production routes, including the accelerator- and reactor-based ones, providing a comprehensive overview of the actual 67Cu supply, with brief insight into its use in non-clinical and clinical studies. In addition to the most often explored nuclear reactions, this work focuses on the 67Cu separation and purification techniques, as well as the target material recovery procedures that are mandatory for the economic sustainability of the production cycle. The quality aspects, such as radiochemical, chemical, and radionuclidic purity, with particular attention to the coproduction of the counterpart 64Cu, are also taken into account, with detailed comparisons among the different production routes. Future possibilities related to new infrastructures are included in this work, as well as new developments on the radiopharmaceuticals aspects.

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“…Nickel target was irradiated using the cyclotron at the Skobeltsyn Institute of Nuclear Physics, Moscow State University. The 64 Cu was produced according to the 64 Ni(p,n) 64 Cu reaction [ 29 ] from a nickel metal target (0.5 g) of natural isotopic composition using an 8-MeV proton beam at 1 μA for 3.5 h. Separation was performed on Cu Resin (Triskem), as previously described [ 30 ]. The resulting carrier-free radionuclide solutions in each experiment was added along with the solution of stable Cu(ClO 4 ) 2 .…”

Section: Methodsmentioning

confidence: 99%

Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make

et al. 2022

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A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied. The prepared benzoazacrown ether with hybrid pendant arms and its complexes with copper and lead cations were studied in terms of biomedical applications. Similarly to a fully acetate analog, the new one binds both cations with close stability constants, despite the decrease in both constants. The calculated geometry of the complexes correlate with the data from X-ray absorption and NMR spectroscopy. Coordination of both cations differs due to the difference between the ionic radii. However, these chelation modes provide effective shielding of cations in both cases, that was shown by the stability of their complexes in the biologically relevant media towards transchelation and transmetallation.

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Photonuclear production and radiochemical separation of medically relevant radionuclides: 67Cu

Cited by 24 publications

References 45 publications

Comparative Study of Macrocyclic and Acyclic Picolinate Derivatives for Chelation of Copper Cations

Comparative Study of Macrocyclic and Acyclic Picolinate Derivatives for Chelation of Copper Cations

67Cu Production Capabilities: A Mini Review

Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make

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