Photophysical and cellular uptake properties of novel phosphorescent cyclometalated iridium(iii) bipyridine d-fructose complexes

Lo, Kenneth Kam‐Wing; Law, Wendell Ho-Tin; Chan, Joey Cho-Yi; Liu, Huawei; Zhang, Kenneth Yin

doi:10.1039/c3mt20276c

Cited by 41 publications

(31 citation statements)

References 22 publications

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“…The phototoxic indexes of 3 against HeLa, A549 and A549R are 49, 239 and 3488, respectively. To the best of our knowledge, these are among the highest phototoxic index values ever reported for iridium complexes [41,64,65]. The result suggests that these Ir(III)eNHCs complexes may be used as potent photodynamic therapeutic agents.…”

Section: Photodynamic Activitymentioning

confidence: 70%

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

et al. 2015

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Section: Photodynamic Activitymentioning

confidence: 70%

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

et al. 2015

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“…d ‐Fructose‐conjugated phosphorescent Ir III complexes have also been reported for mitochondria‐targeting PDT (Scheme ). Lo and colleagues found that the hydrophilic nature of fructose group significantly reduces the dark toxicity of complexes and also observed a decrease in cell uptake of the fructose‐conjugated complexes 54 and 56 in MCF‐7 breast cancer cells when compared to that of the non‐fructose analogues 55 and 57 . Cellular imaging confirmed that the uptake of 56 was energy‐dependent, regulated by membrane‐bound fructose transporters, and located in mitochondria.…”

Section: Organelle‐specific Iriii Complexesmentioning

confidence: 92%

Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy

2018

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Photodynamic therapy (PDT) is a noninvasive treatment for certain types of cancer, bacterial, fungal and viral infections, and skin diseases. In recent years, adaptation of this treatment so as to achieve more specific targeted cancer therapy in particular has attracted significant attention. We focus herein on the design of novel iridium-based photosensitizers (PSs) with tunable photophysical and photobiological properties as efficient PDT agents. We highlight the ability of some Ir photosensitizers to target specific cellular components, including their activation by one- and two-photon irradiation.

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“…The substrates of GLUTs are not limited to glucose; for example, GLUT5, which is overexpressed in breast cancer tissues, selectively mediates the [29] and Zhang and Lo [16] with permission of American Chemical Society uptake of fructose [33,34]. An iridium(III) fructose complex 62 shows enhanced uptake by breast cancer MCF-7 cells and localizes in the mitochondria [35]. The uptake is inhibited by exogenous fructose.…”

Section: Iridium(iii) Complexes Containing Biological Substratesmentioning

confidence: 99%

Phosphorescent Iridium(III) Complexes for Bioimaging

Zhang

Liu

Zhao

et al. 2014

Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents

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Phosphorescent iridium(III) complexes have received increasing attention in bioimaging applications owing to their advantageous photophysical properties and efficient internalization into live cells. In this chapter, we summarize the recent design of bioimaging reagents based on phosphorescent iridium(III) complexes. The utilizations of cationic, neutral, and zwitterionic phosphorescent iridium(III) complexes in bioimaging applications have been described first.Complexes showing aggregation-induced phosphorescence have also been included considering the absence of the commonly observed aggregation-caused quenching. Then we discuss the functionalization of iridium(III) complexes with biological substrates and reactive groups, which allows non-covalent and covalent interaction, respectively, with intracellular biomolecules. As the photophysical properties of iridium(III) complexes are very sensitive toward their surrounding ligands and microenvironment, the use of these complexes as intracellular sensors for gas molecules, ions, and amino acids has been summarized. Additionally, the incorporation of iridium(III) complexes into dendrimer, polymer, and nanoparticle systems providing attractive functionalities has been discussed. Furthermore, various strategies, including the use of near-infrared-emitting and two-photon excitable complexes, upconversion nanoparticles, and lifetime-based microscopy techniques, to enhance signal-to-noise ratios in bioimaging have been discussed. At last, the design of reagents for multi-mode imaging techniques involving phosphorescence and magnetic resonance imaging has been described.

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Photophysical and cellular uptake properties of novel phosphorescent cyclometalated iridium(iii) bipyridine d-fructose complexes

Abstract: We report here the synthesis, characterization and photophysical properties of two novel phosphorescent cyclometalated iridium(III) polypyridine D-fructose complexes and their fructose-free counterparts. The cellular uptake of the complexes and their cytotoxicity have also been examined.

Cited by 41 publications

References 22 publications

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy

Phosphorescent Iridium(III) Complexes for Bioimaging

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