Photosensitivity in panic disorder

Bossini, Letizia; Fagiolini, Andrea; Valdagno, Marta; Padula, L.; Hofkens, Tara; Castrogiovanni, Paolo

doi:10.1002/da.20477

Cited by 18 publications

(21 citation statements)

References 16 publications

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“…Patients with anxiety and panic disorder also tend to have a lowered threshold of tolerance to light. The light threshold in these patients also responded to behavioral modifications and therapy (52). Given the comorbidity of these disorders with neuro-ophthalmic disease (especially migraine), one might expect an association.…”

Section: Conditions Associated With Photophobia (Table 1)mentioning

confidence: 94%

“…For many years, migraine and blepharospasm were thought to be functional disorders (55). Certainly, photophobia accompanies depression and anxiety (52); this can make patient interaction and management difficult. As already discussed, photophobia can be diagnosed in association with migraine, blepharospasm, PSP, depression and anxiety—all conditions with an anatomical and physiological basis, and for which many treatments now are available.…”

Section: Conditions Associated With Photophobia (Table 1)mentioning

confidence: 99%

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Shedding Light on Photophobia

Digre

Brennan²

2012

Journal of Neuro-Ophthalmology

233

239

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Photophobia is a common yet debilitating symptom seen in many ophthalmic and neurologic disorders. Despite its prevalence, it is poorly understood and difficult to treat. However, the past few years have seen significant advances in our understanding of this symptom. We review the clinical characteristics and disorders associated with photophobia, discuss the anatomy and physiology of this phenomenon, and conclude with a practical approach to diagnosis and treatment.

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Section: Conditions Associated With Photophobia (Table 1)mentioning

confidence: 94%

Section: Conditions Associated With Photophobia (Table 1)mentioning

confidence: 99%

Shedding Light on Photophobia

Digre

Brennan²

2012

Journal of Neuro-Ophthalmology

233

239

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“…Photosensitivity was measured using the Photosensitivity Assessment Questionnaire (PAQ), which was developed and validated in an Italian population . The PAQ is a 16‐item questionnaire which features 8 questions regarding photophobic or “light‐avoiding” behavior and 8 questions regarding photophilic or “light‐liking” behavior.…”

Section: Methodsmentioning

confidence: 99%

“…On the photophobia scale, affirmative answers are rated as a “1” and negative answers are rated as a “0” for a total score between 0 and 8. Prior studies in healthy controls have reported a mean (SD) score of 0.11‐0.12 …”

Section: Methodsmentioning

confidence: 99%

Sensory Hypersensitivity Symptoms in Migraine With vs Without Aura: Results From the American Registry for Migraine Research

et al. 2020

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Background and Objectives Migraine with aura (MwA) is associated with increased brain hyper‐responsiveness to visual stimuli and increased visual network connectivity relative to migraine without aura (MwoA). Despite this, prior studies have provided conflicting results regarding whether MwA is associated with higher photophobia symptom scores compared to MwoA. The relationships between MwA and other types of sensory hypersensitivity, such as phonophobia and cutaneous allodynia (CA), have not been previously investigated. The purpose of this cross‐sectional observational study was to investigate whether MwA is associated with greater symptoms of photophobia, phonophobia, and CA compared to MwoA. Methods This analysis included 321 migraine patients (146 MwA; 175 MwoA) who had been enrolled into the American Registry for Migraine Research. The diagnosis of either MwoA or MwA was determined by headache specialists using ICHD diagnostic criteria. Patients completed the Photosensitivity Assessment Questionnaire, the Hyperacusis Questionnaire, and the Allodynia Symptom Checklist. Mean or median values were compared between groups. Regression models were created to analyze the relationship between MwA with photophobia scores, hyperacusis scores, and the presence of interictal CA. Results Those with MwA had higher mean photophobia scores than those with MwoA (4.1 vs 3.0, P = .0003). MwA was positively associated with photophobia symptom severity (B = 0.50 [SE = 0.14], P = .0003), after controlling for age, patient sex, and headache frequency. Aura was not associated with hyperacusis symptom severity (B = 0.07 [SE = 0.08], P = .346) or the presence of interictal CA (OR 1.33 [95% CI 0.70‐2.53], P = .381). Conclusion MwA is associated with higher photophobia symptom scores compared to MwoA. Aura is not associated with greater hyperacusis or interictal allodynia scores. These findings complement prior imaging and neurophysiologic studies that demonstrated MwA to be associated with hyper‐responsiveness of brain visual processing regions. The findings suggest that MwA is associated specifically with visual hypersensitivity, as opposed to being associated with a general hypersensitivity to multiple types of sensory stimuli.

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“…Previous studies indicate lower thresholds of light sensitivity for depressed patients and a relationship between light sensitivity and anxiety in psychiatric populations (16,26). Henceforth, the potential relationships between photosensitivity and measures of anxiety and depression as well as migraine-specific characteristics such as headache frequency and years lived with migraine were investigated using post-hoc Pearson's correlations.…”

Section: Photosensitivity Scoresmentioning

confidence: 99%