Photosensitized Peroxidase Mimicry at the Hierarchical 0D/2D Heterojunction‐Like Quasi Metal‐Organic Framework Interface for Boosting Biocatalytic Disinfection

Abstract

Metal‐organic frameworks (MOFs) are a versatile toolbox for the bioinspired design of nanozymes for antibacterial applications and beyond, however, designing a nanozyme by the hierarchical quasi‐MOF scheme remains largely unpracticed. This work exemplifies the preferential structure‐activity correlation of a bimetallic quasi‐MOF (Q‐MOFCe0.5) among three series of MOF‐derived peroxidase (POD) mimics. The biomimetic quasi‐MOFCe0.5 nanosheets accommodate both oxygen vacancy‐coupled multivalent redox cycles and photosensitive energy band layout, benefiting from the hierarchical heterojunction‐like 0D/2D interface featuring isolated nodes‐derived CeOCu sites upon the 2D decarboxylated MOF scaffold. These integrated unique merits enable the POD‐like Q‐MOFCe0.5 to generate sustained reactive oxygen species to effectively eradicate the surface‐adhered bacteria under visible light, resulting in significant inactivation of Escherichia coli (99.74 %) and Staphylococcus aureus (99.35%) in vitro, and potent disinfection of skin wounds in vivo in safe and on‐demand manners. It is hoped that this work can intensify the interventions of MOF nanozymes against the microbial world.

In Situ Implantation of Bi2S3 Nanorods into Porous Quasi-Bi-MOF Architectures: Enabling Synergistic Dissociation of Borohydride for an Efficient and Fast Catalytic Reduction of 4-Nitrophenol

“…This phenomenon is also observed in other inorganic nanocrystallites/quasi-MOF systems. , Meanwhile, the pore diameter of Bi-MOF is mainly located at 1.1 nm, while Bi 2 S 3 @quasi-Bi-MOF exhibits a micropore diameter of 1.6 nm and a mesopore diameter centered at 26.1 nm, indicating the partial preservation of the porous structure of parent MOF in Bi 2 S 3 @quasi-Bi-MOF. Therefore, the variation of the BET specific surface area and pore diameter after the in situ generation of Bi 2 S 3 in quasi-Bi-MOF reflects a controlled deligandation process …”

“…Therefore, the variation of the BET specific surface area and pore diameter after the in situ generation of Bi 2 S 3 in quasi-Bi-MOF reflects a controlled deligandation process. 44 The morphology and microstructure of Bi 2 S 3 @quasi-Bi-MOF were examined by scanning electron microscopy (SEM). As shown in Figure S2, the parent Bi-MOF presents a typical hexagonal prism-shaped nanorod structure with a diameter of 600−900 nm and a length of about 3−5 μm, which matches the intrinsic structure of Bi-based CAU-17 MOF.…”

A State-of-the-Art of Metal-Organic Frameworks for Chromium Photoreduction vs. Photocatalytic Water Remediation

“…In addition, copper is a well-known active metal center for the oxidative catalytic degradation of organic pollutants such as phenols. For instance, as the oxidative degradation by copper sites depends on the generation of oxygen radicals such as hydrogen peroxide, exciton generation through light illumination can induce an enhancement in ROS generation, Cu center activation, and finally, organic pollutant oxidation [ 218 , 219 , 220 ].…”

Nanozyme: A new Approach for Anti-microbial Infections

“…Huang et al [32] have designed a bimetallic quasi-MOF nanozyme (Q-MOFCe0.5) with peroxidase-like activity. Such nanosheets featured by a layered heterogeneous junctional interface can continuously produce ROS to achieve effective killing of Escherichia coli (99.74 %) and Staphylococcus aureus (99.35%) in vitro, and the morphology analysis clearly shows that the attacked bacteria lose their normal shape (Fig 2).…”