Phototherapy using narrowband ultraviolet B and psoralen plus ultraviolet A is beneficial in steroid‐dependent antihistamine‐refractory chronic urticaria: a randomized, prospective observer‐blinded comparative study

Bishnoi, Anuradha; Parsad, Davinder; Vinay, Keshavamurthy

doi:10.1111/bjd.14778

Cited by 33 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, UVR therapy appears to be helpful in reducing the symptoms of urticaria, with PUVA and UVA and also PUVA and NB‐UVB showing comparable results. Recently, both PUVA and NB‐UVB were effective in steroid‐dependent antihistamine‐refractory chronic urticaria, with NB‐UVB being statistically better . The use of different outcome measures such as visual analogue score, outcome scoring scale, urticaria activity score and quality of life impedes the direct comparison of studies …”

Section: Uv Treatment In Mast Cell‐driven Diseasesmentioning

confidence: 99%

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Siiskonen

Smorodchenko

Krause

et al. 2017

Experimental Dermatology

View full text Add to dashboard Cite

Mast cells (MCs) are well known as versatile effector cells in allergic reactions and several other immune responses. Skin MCs and cutaneous MC responses are subject to the effects of environmental factors including ultraviolet radiation (UVR). Numerous studies have assessed the effects of UVR on MCs, in vitro and in vivo. Interestingly, UVR seems to have variable effects on non-activated and activated mast cells. In general, UV therapy is beneficial in the treatment of urticaria and mastocytosis, but the effects are variable depending on treatment regimen and type of UVR. Here, we review and summarise key reports from the older and current literature on the crosstalk of UVR and skin MCs. Specifically, we present the literature and discuss published reports on the effects of UVR on skin MCs in rodents and humans. In addition, we review the role of MCs in UVR-driven skin diseases and the influence of UV light on MC-mediated skin diseases. This summary of our current understanding of the interplay of skin MCs and UVR may help to improve the management of patients with urticaria and other MC disorders, to identify current gaps of knowledge, and to guide further research. K E Y W O R D Scancer, mast cell, ultraviolet radiation, urticaria

show abstract

Section: Uv Treatment In Mast Cell‐driven Diseasesmentioning

confidence: 99%

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Siiskonen

Smorodchenko

Krause

et al. 2017

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…Psoralen is extracted from dried fruits of P. corylifolia (L.) from Leguminosae, which shows an active effect including anti-tumor, photosensitivity, cardiovascular protection, anti-histamine and estrogen-like pharmacological effects [25][26][27][28][29]. In the traditional Chinese medicine, the property and flavor of P. corylifolia (L.) are spicy, bitter and warm, and it has warming kidney and enhancing yang, preventing asthma, to warm the kidney and the spleen and check diarrhea, and removing beverage effect [30], and P. corylifolia can be used as basic remedy to suppress tumor [13-15, 31, 32].…”

Section: Discussionmentioning

confidence: 99%

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

et al. 2019

View full text Add to dashboard Cite

Background: Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects. Results: Psoralen inhibited proliferation of SMMC7721 in a dose-and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1α, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn't inhibit the psoralen-induced ER stress in SMMC7721 cells. Conclusions: Psoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.

show abstract

“…Phototherapy It is useful in solar and physical urticarias, suitable for patients who visit frequently or intolerant to systemic treatment. 57 Narrowband UVB is effective, safe and affordable for steroid-dependent CRU. Autohemotherapy It 58 involves the parenteral injection of autologous blood to desensitize patients to pro-urticarial factors in his serum 2 and improved quality of life.…”

Section: Nondrug Therapiesmentioning

confidence: 99%

Management of Chronic Urticaria

Iftikhar¹,

Hasan²

2020

JRMC

View full text Add to dashboard Cite

The management of urticaria, although complex, relies on two postulates: • Recognition and eradication of the triggering factor(s) • Provision of symptomatic relief Recognition and eradication of the triggering factors(s) Factors known are drugs, food, infections, and physical stimuli. Drugs: Analgesics and NSAIDs can exacerbate already present urticaria and are also recognized triggers of new-onset urticaria.2 When suspected, they should be withdrawn entirely or can be replaced. ACE inhibitors can cause angioedema. Eradication of infectious agents Infections and infestations should be treated where suspected, including infections of the GI tract e.g., H Pylori associated gastritis3, nasopharyngeal bacterial infections, and intestinal worms.8 Management of diet The allergens in food need to be avoided if a patient has type I hypersensitivity to any one of these allergens. Pseudo-allergic reactions5 which are not IgE mediated have been described for organic foods and food additives.9-13 Physical stimuli They are usually recognized and controlled, e.g., in chronic pressure urticaria patients are advised to use bags with a wide handle and similarly, in symptomatic dermographism, simple avoidance of friction can give relief from symptoms.15 Symptomatic therapy One of the objectives of symptomatic therapy is to mask the effects of histamine, platelet-activating factor, and other mast cell mediators. Histamine plays a primary role in inducing the symptoms associated with urticaria. The activation of receptors on endothelial cells by histamine results in wheals whereas this histamine receptor activation on sensory nerves results in itching. Different guidelines have been proposed for managing chronic urticaria including the EACCI [5] and BSACI [4].

show abstract

Phototherapy using narrowband ultraviolet B and psoralen plus ultraviolet A is beneficial in steroid‐dependent antihistamine‐refractory chronic urticaria: a randomized, prospective observer‐blinded comparative study

Abstract: Phototherapy, especially NB-UVB, is an effective, safe and affordable therapeutic modality for steroid-dependent CRU and should be tried prior to third-line treatment options such as omalizumab, ciclosporin and other immunosuppressants.

Cited by 33 publications

References 31 publications

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

Management of Chronic Urticaria

Contact Info

Product

Resources

About