Photothermal Effect and Multi-Modality Imaging of Up-Conversion Nanomaterial Doped with Gold Nanoparticles

Abstract

Two key concerns exist in contemporary cancer chemotherapy in clinics: limited therapeutic efficiency and substantial side effects in patients. In recent years, researchers have been investigating revolutionary cancer treatment techniques and photo-thermal therapy (PTT) has been proposed by many scholars. A drug for photothermal cancer treatment was synthesized using the hydrothermal method, which has a high light-to-heat conversion efficiency. It may also be utilized as a clear multi-modality bioimaging platform for photoacoustic imaging (PAI), computed tomography (CT), and magnetic resonance imaging (MRI). When compared to single-modality imaging, multi-modality imaging delivers far more thorough and precise details for cancer diagnosis. Furthermore, gold-doped upconverting nanoparticles (UCNPs) have an exceptionally high target recognition for tumor cells. The gold-doped UCNPs, in particular, are non-toxic to normal tissues, endowing the as-prepared medications with outstanding therapeutic efficacy but exceptionally low side effects. These findings may encourage the creation of fresh effective imaging-guided approaches to meet the goal of photothermal cancer therapy.

Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review

“…In this line [2], the researcher investigated the multi-modality imaging and photothermal effect of gold-doped upconverting nanoparticles (UCNPs). Zhang et al [28] pointed out that due to photothermal stability, low cytotoxicity, and high biocompatibility, Au-UCNPs-DSPE-PEG 2k may be utilized as MRI and CT contrast agents for both in vivo and in vitro, and may also be used for photothermal treatment.…”

Nanotheranostics for Image-Guided Cancer Treatment

“…Notably, some inorganic NPs are inherently imageable due to their optical and magnetic properties. For example, fluorescent gold NPs can be detected optically or in photoacoustic imaging (PAI) [ 20 ], and iron oxide NPs can be detected in MRI [ 21 ], in addition to their capacity to load drugs. The following section will introduce characteristics of NPs in each category and their potential modification strategies.…”

Gold Nanorod-Loaded Nano-Contrast Agent with Composite Shell-Core Structure for Ultrasonic/Photothermal Imaging-Guided Therapy in Ischemic Muscle Disorders

“…Additionally, nano-photothermal therapy has emerged as a significant advancement in biological therapy, notable for its wide applicability, selectivity, and operational ease. 7 As a traditional treatment, thermal therapy inflicts minimal damage to normal tissues and is a mainstay in managing various chronic diseases, earning its place as a primary therapy in rehabilitation sports medicine. However, the efficacy of traditional thermal therapy is hampered by low heat transfer efficiency and limited therapeutic outcomes.…”