Photothermal Ring Integrated Intraocular Lens for High‐Efficient Eye Disease Treatment

Abstract

Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) is reported, in which the rim of commercially available IOLs (C-IOLs) is decorated with silica coated Au nanorods (Au@SiO ), for high-efficient prevention of PCO after cataract surgery. The Nano-IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano-IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano-IOLs shows good biocompatibility as well as extraordinary region-confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%-40% by using Nano-IOLs, which is significantly lower than the control group that treated with C-IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO-induced loss of vision.

Gold nanoparticles in ophthalmology

“…Cataract surgery often leads to a posterior capsule opacification (PCO) . An intraocular lens (IOL) used for the cataract was improved by the use of GNR and their photothermal properties . Commercial IOL were functionalized with GNR previously coated with silica (Figure ).…”

“…Focused laser surgery at 808 nm leads to a photothermal effect, reducing the PCO occurrence by about 60% after 30 days. Reprinted with permission of John Wiley & Sons (Wang's group).…”

Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

“…[8] The photothermal conversion of these materials is controlled by simple and flexible non-covalent intermolecular interactions, and distinguished from molecular structural design. [9][10][11][12][13][14][15][16] Due to these unique features, much effort has been put into developing novel supramolecular strategies and promoting their photothermal conversion performance. [17][18][19][20] However, the rational design of highly efficient photothermal materials requires a comprehensive understanding of the photothermal conversion mechanism, which has not yet been clearly detailed.…”

Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification

“…Recently, IOL modification is considered as a new potential strategy for PCO prevention [ 6 , [26] , [27] , [28] ]. However, it is still challenging to maintain the refractive properties of IOLs and also avoid possible damage to intraocular tissue.…”