Phycocyanin Improves Reproductive Ability in Obese Female Mice by Restoring Ovary and Oocyte Quality

Wen, Xin; Han, Zhe; Liu, Shujun; Hao, Xin; Zhang, Xiaojie; Wang, Xingyue; Zhou, Cheng-Jie; Ma, Yuzhen; Liang, Cheng-Guang

doi:10.3389/fcell.2020.595373

Cited by 30 publications

(25 citation statements)

References 66 publications

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“…Firstly, mouse [ 46 ], bovine [ 20 , 175 ], pig [ 45 , 85 ], human [ 4 , 79 ], and non-human primate [ 57 , 86 , 87 ] models showed that compared to the control group, the high-fat diet group exhibited fewer collected MII oocytes. An increased rate of gametes that were not able to resume meiosis and were thus arrested at Prophase I of the meiotic cell cycle was also observed in mice [ 33 , 40 , 46 , 48 , 99 , 100 , 114 , 132 , 176 , 177 , 178 ] and pigs [ 45 , 85 ], with an incidence of oocyte degeneration [ 48 , 99 , 176 , 179 , 180 , 181 ] in rats [ 42 ] and bovines [ 182 ].…”

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 95%

“…Lastly, morphological defects such as disrupted meiotic spindle and chromosome morphology have been reported in several studies in mice [ 46 , 48 , 55 , 100 , 117 , 132 , 176 , 177 , 178 , 179 , 183 , 185 , 187 ]. Specifically, these studies showed that exposure to spindle disrupting compounds can impair in oocyte meiotic division and genomic stability, compromising their ability to reach meiotic competence.…”

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 99%

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High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

et al. 2022

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Female reproduction focuses mainly on achieving fully grown follicles and competent oocytes to be successfully fertilized, as well as on nourishing the developing offspring once pregnancy occurs. Current evidence demonstrates that obesity and/or high-fat diet regimes can perturbate these processes, leading to female infertility and transgenerational disorders. Since the mechanisms and reproductive processes involved are not yet fully clarified, the present review is designed as a systematic and comparative survey of the available literature. The available data demonstrate the adverse influences of obesity on diverse reproductive processes, such as folliculogenesis, oogenesis, and embryo development/implant. The negative reproductive impact may be attributed to a direct action on reproductive somatic and germinal compartments and/or to an indirect influence mediated by the endocrine, metabolic, and immune axis control systems. Overall, the present review highlights the fragmentation of the current information limiting the comprehension of the reproductive impact of a high-fat diet. Based on the incidence and prevalence of obesity in the Western countries, this topic becomes a research challenge to increase self-awareness of dietary reproductive risk to propose solid and rigorous preventive dietary regimes, as well as to develop targeted pharmacological interventions.

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Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 95%

Section: High-fat Diet Impact On Oocyte Developmental Competencementioning

confidence: 99%

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

et al. 2022

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“…In this experiment, we used MSmPNPs as a component to improve porcine IVM and subsequent preimplantation embryo development. Recent study showed that the biliprotein phycocyanin, derived from Spirulina platensis , enhanced the developmental competence of the oocytes from obese female mice [ 50 ]. Additionally, IVM supplementation with phycocyanin improved the embryonic development of parthenogenetic and cloned embryos in porcine [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Modified Spirulina maxima Pectin Nanoparticles Improve the Developmental Competence of In Vitro Matured Porcine Oocytes

Roy

Qamar

Tanga

et al. 2021

Animals

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Molecular approaches have been used to determine metabolic substrates involved in the early embryonic processes to provide adequate culture conditions. To investigate the effect of modified Spirulina maxima pectin nanoparticles (MSmPNPs) on oocyte developmental competence, cumulus–oocyte complexes (COCs) retrieved from pig slaughterhouse ovaries were subjected to various concentrations of MSmPNPs (0, 2.5, 5.0, and 10 µg/mL) during in vitro maturation (IVM). In comparison to the control, MSmPNPs-5.0, and MSmPNPs-10 groups, oocytes treated with 2.5 µg/mL MSmPNPs had significantly increased glutathione (GSH) levels and lower levels of reactive oxygen species (ROS). Following parthenogenetic activation, the MSmPNPs-2.5 group had a considerably higher maturation and cleavage rates, blastocyst development, total cell number, and ratio of inner cell mass/trophectoderm (ICM:TE) cells, when compared with those in the control and all other treated groups. Furthermore, similar findings were reported for the developmental competence of somatic cell nuclear transfer (SCNT)-derived embryos. Additionally, the relative quantification of POU5F1, DPPA2, and NDP52 mRNA transcript levels were significantly higher in the MSmPNPs-2.5 group than in the control and other treated groups. Taken together, the current findings suggest that MSmPNP treatment alleviates oxidative stress and enhances the developmental competence of porcine in vitro matured oocytes after parthenogenetic activation and SCNT.

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“…49 In recent years, many studies have demonstrated that C-phycocyanin is useful for animal health, and especially to reproductive function. [23][24][25] However, there are few reports of the effects of C-phycocyanin on the male reproductive system.…”

Section: Papermentioning

confidence: 99%

“…C-phycocyanin was proved to improve fertility by improving ovary and oocyte quality in obese female mice. 23 C-phycocyanin has beneficial effects on the development of porcine parthenotes by attenuating mitochondrial dysfunction and oxidative stress, 24 and may be useful for improving porcine oocyte quality and subsequent developmental competence in embryos. 25 Necroptosis is a type of programmed necrotic cell death and caused by the tumor necrosis factor family of cytokines.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of C-phycocyanin in male mouse reproductive system

et al. 2022

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Phycocyanin Improves Reproductive Ability in Obese Female Mice by Restoring Ovary and Oocyte Quality

Cited by 30 publications

References 66 publications

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

Modified Spirulina maxima Pectin Nanoparticles Improve the Developmental Competence of In Vitro Matured Porcine Oocytes

The protective effect of C-phycocyanin in male mouse reproductive system

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