PHYL Acts to Down-Regulate TTK88, a Transcriptional Repressor of Neuronal Cell Fates, by a SINA-Dependent Mechanism

Tang, Amy; Neufeld, Thomas P.; Kwan, Elaine; Rubin, Gerald M.

doi:10.1016/s0092-8674(00)80506-1

Cited by 220 publications

(247 citation statements)

References 63 publications

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“…These studies support our current results that Siah1 expression itself may influence the progression of NPC. Siah might serve a similar role as a downstream pathway component essential for oncogenic Ras signal as described in Drosophila [10,26,27]. Since Ras signal closely associated with cancer progression and transformation, such signal cascade may affect tumour progression by Siah1 as well as in human.…”

Section: Discussionmentioning

confidence: 88%

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

et al. 2013

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(T. Yoshizaki). Keywords:seven-in-absentia homologue 1 (Siah1) hypoxia-inducible factor 1 alpha (HIF1α) latent membrane protein 1 (LMP1) Epstein-Barr virus (EBV) nasopharyngeal carcinoma ABSTRACT Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis.

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Section: Discussionmentioning

confidence: 88%

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

et al. 2013

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“…As described above, activation of Notch prevents R7 from assuming the R1/R6 fate. One important function of RTKs in the presumptive R7 is to activate an E3 Ligase complex composed of Seven in absentia (Sina), Phyllopod (Phyl), and Ebi (Li et al, 1997;Tang et al, 1997;Dong et al, 1999;Boulton et al, 2000;Li et al, 2002). This E3 complex ubiquitinates Tramtrack88 (Ttk88), a transcriptional repressor, targeting it for proteolysis.…”

Section: Photoreceptor R7mentioning

confidence: 99%

Signal integration during development: Insights from the Drosophila eye

Voas

Rebay

2003

Developmental Dynamics

162

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The Drosophila eye is a highly ordered epithelial tissue composed of ϳ750 subunits called ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of the constituent photoreceptors, cone cells, and pigment cells of the eye reveals a highly ordered mosaic of amazing regularity. This relatively simple organization belies the repeated requirement for spatially and temporally coordinated inputs from the Hedgehog (Hh), Wingless (Wg), Decapentaplegic (Dpp), JAK-STAT, Notch, and receptor tyrosine kinase (RTK) signaling pathways. This review will discuss how signaling inputs from the Notch and RTK pathways, superimposed on the developmental history of a cell, facilitate context-specific and appropriate cell fate specification decisions in the developing fly eye. Lessons learned from investigating the combinatorial signal integration strategies underlying Drosophila eye development will likely reveal cell-cell communication paradigms relevant to many aspects of invertebrate and mammalian development. Developmental Dynamics 229:162-175, 2004.

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“…Studies on photoreceptor cell differentiation of the Drosophila eye have shown that activation of the Ras/Map kinase-signaling cascade results in the ubiquitin-mediated degradation of Tramtrack (TTK) Tang et al 1997), a transcriptional repressor of neuronal cell fates, as well as of the transcription factor YAN (Rebay and Rubin 1995), a general inhibitor of differentiation of many cell types in the Drosophila eye. Therefore, we examined whether the Bcr-Abl-mediated down-regulation of Abi expression is Ras dependent.…”

Section: Bcr-abl-mediated Down-regulation Of Abi Expression Is Ras Inmentioning

confidence: 99%

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

et al. 1998

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Oncogenic forms of the Abl and Src tyrosine kinases trigger the destruction of the Abi proteins, a family of Abl-interacting proteins that antagonize the oncogenic potential of Abl after overexpression in fibroblasts. The destruction of the Abi proteins requires tyrosine kinase activity and is dependent on the ubiquitin-proteasome pathway. We show that degradation of the Abi proteins occurs through a Ras-independent pathway. Significantly, expression of the Abi proteins is lost in cell lines and bone marrow cells isolated from patients with aggressive Bcr-Abl-positive leukemias. These findings suggest that loss of Abi proteins may be a component in the progression of Bcr-Abl-positive leukemias and identify a novel pathway linking activated nonreceptor protein tyrosine kinases to the destruction of specific target proteins through the ubiquitinproteasome pathway.

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PHYL Acts to Down-Regulate TTK88, a Transcriptional Repressor of Neuronal Cell Fates, by a SINA-Dependent Mechanism

Cited by 220 publications

References 63 publications

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

Signal integration during development: Insights from the Drosophila eye

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

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