Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Yang, Heng-Gang; Zhao, Huan; Li, Jiaojiao; Chen, Shao-Meng; Mou, Lang-Ming; Zou, Jian; Chen, Guodong; Qin, Sheng-Ying; Wang, Chuanxi; Hu, Dan; Yao, Xin‐Sheng; Gao, Hao

doi:10.1038/s41598-017-13407-y

Cited by 12 publications

(8 citation statements)

References 35 publications

(45 reference statements)

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“…J13-2-12Y from the leaves of Acorus tatarinowii resulted in the isolation of 3 unusual meroterpenoids, phyllomeroterpenoids A-C ( 193 - 195 ). 67 Five meroterpenoids, phyllostictones A-E ( 196 - 200 ), were isolated from Phyllosticta capitalensis , an endophytic fungus from Cephalotaxus fortunei Hook. 68…”

Section: Resultsmentioning

confidence: 99%

Progress on Terpenoids With Biological Activities Produced by Plant Endophytic Fungi in China Between 2017 and 2019

Zhou

Cui

Liu

et al. 2020

Natural Product Communications

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Plant endophytic fungi are an important part of plant microecosystems and a natural resource for human survival and development. Various bioactive natural products produced by plant endophytic fungi show promising prospects in biopharmacy, agricultural production, and industrial fermentation. Terpenoids, the most numerous and structurally diverse natural products from endophytic fungi, possess a broad range of biological activities and huge potential for drug development. It is critically significant for ecological and economic benefits to develop their activities. This paper utilized literature analysis to summarize 200 terpenoids with biological activities that are derived from plant endophytic fungi in China between 2017 and 2019. Among them, sesquiterpenoids were the most important kind of terpenoids, and Trichoderma and Aspergillus species were main terpenoid-producing plant endophytic fungi. Furthermore, these terpenoids displayed multifarious biological activities, including antimicrobial, antipathogenic, and anti-inflammatory activities, as well as cytotoxicity, antitumor agents, and enzyme inhibition.

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Section: Resultsmentioning

confidence: 99%

Progress on Terpenoids With Biological Activities Produced by Plant Endophytic Fungi in China Between 2017 and 2019

Zhou

Cui

Liu

et al. 2020

Natural Product Communications

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“…J13-2-12Y fermentation broth. Compounds 176-178 showed moderate antimicrobial activities against Staphylococcus aureus 209P, Candida aureus 209P, and Candida albicans FIM709, with MIC values ranging from 32 to 128 µg/mL [92]. Austin 179 (Figure 12) was obtained from the ethyl acetate extract of Talaromyces purpurogenus H4 and Phanerochaete sp.…”

Section: Meroterpenoidsmentioning

confidence: 99%

“…AZ0432 of Ceratodon purpureus. The in vitro cytotoxic activities of compound 138 against five human cancer cell lines (NCI-H460, MDA-MB-231, [92]. Austin 179 (Figure 12) was obtained from the ethyl acetate extract of Talaromyces purpurogenus H4 and Phanerochaete sp.…”

Section: Diterpenoidsmentioning

confidence: 99%

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies

Wen

Okyere

Wang

et al. 2022

JoF

110

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Plant-associated fungi (endophytic fungi) are a biodiversity-rich group of microorganisms that are normally found asymptomatically within plant tissues or in the intercellular spaces. Endophytic fungi promote the growth of host plants by directly producing secondary metabolites, which enhances the plant’s resistance to biotic and abiotic stresses. Additionally, they are capable of biosynthesizing medically important “phytochemicals” that were initially thought to be produced only by the host plant. In this review, we summarized some compounds from endophyte fungi with novel structures and diverse biological activities published between 2011 and 2021, with a focus on the origin of endophytic fungi, the structural and biological activity of the compounds they produce, and special attention paid to the exploration of pharmacological activities and mechanisms of action of certain compounds. This review revealed that endophytic fungi had high potential to be harnessed as an alternative source of secondary metabolites for pharmacological studies.

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“…Yang et al isolated phyllomeroterpenoids A–C and six biosynthetically related compounds (S, Z)-guignardianone C, (S, Z)-botryosphaerin B, (4S, 6R, 9S, 10R, 14R) −17-hydroxylated guignardone A, (S, Z)-phenguignardic acid methyl ester (4S, 6R, 9, 10, 12S, 14R)−12-hydroxylated guignardone A, and (4S, 6R, 9S, 10R, 14R)-guignardone B from fungus Phyllosticta sp. Only compound (S, Z)-phenguignardic acid methyl ester with MIC values of 4 μg/ml showed significant anti-microbial activity against S. aureus 209P and C. albicans FIM709 ( Yang et al, 2017 ). Duan et al isolated meroterpenoids preaustinoid D and dihydroxyneogrifolic acid, a neogrifolin derivative, Austin, and (S)-18,19-dihydroxyneogrifolin from Gastrodia elata Blume, associated with Penicillium sp.…”

Section: Biological Activities Of Meroterpenoidsmentioning

confidence: 99%

Biological activities of meroterpenoids isolated from different sources

et al. 2022

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Meroterpenoids are natural products synthesized by unicellular organisms such as bacteria and multicellular organisms such as fungi, plants, and animals, including those of marine origin. Structurally, these compounds exhibit a wide diversity depending upon the origin and the biosynthetic pathway they emerge from. This diversity in structural features imparts a wide spectrum of biological activity to meroterpenoids. Based on the biosynthetic pathway of origin, these compounds are either polyketide-terpenoids or non-polyketide terpenoids. The recent surge of interest in meroterpenoids has led to a systematic screening of these compounds for many biological actions. Different meroterpenoids have been recorded for a broad range of operations, such as anti-cholinesterase, COX-2 inhibitory, anti-leishmanial, anti-diabetic, anti-oxidative, anti-inflammatory, anti-neoplastic, anti-bacterial, antimalarial, anti-viral, anti-obesity, and insecticidal activity. Meroterpenoids also possess inhibitory activity against the expression of nitric oxide, TNF- α, and other inflammatory mediators. These compounds also show renal protective, cardioprotective, and neuroprotective activities. The present review includes literature from 1999 to date and discusses 590 biologically active meroterpenoids, of which 231 are from fungal sources, 212 are from various species of plants, and 147 are from marine sources such as algae and sponges.

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Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Cited by 12 publications

References 35 publications

Progress on Terpenoids With Biological Activities Produced by Plant Endophytic Fungi in China Between 2017 and 2019

Progress on Terpenoids With Biological Activities Produced by Plant Endophytic Fungi in China Between 2017 and 2019

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies

Biological activities of meroterpenoids isolated from different sources

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