Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia

Duque-Valencia, July; Díaz, Francisco J.; Ruíz-Saenz, Julián

doi:10.3390/pathogens9010026

Cited by 11 publications

(10 citation statements)

References 36 publications

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“…Based on the full sequence of the H gene from CDV strains isolated worldwide [ 14 ], to date, diverse genotypes have been described: America-1 (which includes almost all commercially available vaccine strains), America-2 to -5, Arctic-like, Rockborn-like, Asia-1 to -4, Africa-1 to -2, European Wildlife, Europe/South America-1, South America-2 and -3 and South/North America-4 [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. The South American 3 lineage was previously described as circulating among domestic dog populations in Colombia [ 27 ]. This lineage exhibited differences in the amino acidic sequence in comparison to vaccine and wild-type strains circulating around the world [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

et al. 2021

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Canine morbillivirus (CDV) is a viral agent that infects domestic dogs and a vast array of wildlife species. It belongs to the Paramyxoviridae family, genus Morbillivirus, which is shared with the Measles virus (MeV). Both viruses employ orthologous cellular receptors, SLAM in mononuclear cells and Nectin-4 in epithelial cells, to enter the cells. Although CDV and MeV hemagglutinin (H) have similar functions in viral pathogenesis and cell tropism, the potential interaction of CDV-H protein with human cellular receptors is still uncertain. Considering that CDV is classified as a multi-host pathogen, the potential risk of CDV transmission to humans has not been fully discarded. In this study, we aimed to evaluate both in silico and in vitro, whether there is a cross-species transmission potential from CDV to humans. To accomplish this, the CDV-H protein belonging to the Colombian lineage was modelled. After model validations, molecular docking and molecular dynamics simulations were carried out between Colombian CDV-H protein and canine and human cellular receptors to determine different aspects of the protein–protein interactions. Moreover, cell lines expressing orthologous cellular receptors, with both reference and wild-type CDV strains, were conducted to determine the CDV cross-species transmission potential from an in vitro model. This in silico and in vitro approach suggests the possibility that CDV interacts with ortholog human SLAM (hSLAM) and human Nectin-4 receptors to infect human cell lines, which could imply a potential cross-species transmission of CDV from dogs to humans.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

et al. 2021

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“…It has been stablished for other relevant canine viruses such as CPV-2 and CDV that multiple viral migrations from Europe to South America 44,46,47 . The same pattern could be seen for the CanineCV, for which there are at least two migrations events from Italy, one to Colombia and later, another to Argentina (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…We found four sites for the replicase protein and one for the capsid protein. Some studies might be carried out to set up whether these sites are related to pathogenicity aspects considering the amount of positive selection sites of replicase protein, and immune evasion or antibodies recognition, as reported previously for other canine viral pathogens 46,47 .…”

Section: Discussionmentioning

confidence: 99%

First detection and full genomic analysis of Canine Circovirus in CPV-2 infected dogs in Colombia, South America

Giraldo-Ramirez

Rendón-Marín

Vargas-Bermúdez

et al. 2020

Sci Rep

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Canine Circovirus (CanineCV) is an emerging virus which since its first report in USA in 2012, it has been described worldwide. It was the second mammalian circovirus species identified in dogs and its role in canine enteritis is still being uncertain as much as its association in disease with the Canine Parvovirus-2 (CPV-2). Here, we aim to confirm for the first time the presence of CanineCV in Colombia and to develop phylogenetic evolutive analyses of CanineCV in CPV-2 positive animals. DNA from samples were extracted and PCR, full genome sequencing and phylogenetic analysis was performed to detect and characterize CanineCV. From a total of 30 CPV-2 positive samples, 16.6% (n = 5) were positives for CanineCV. Sequencing analysis of Colombian CanineCV wild-type strains displayed high identity to each other (99.5–99.7% nt; 99.7% aa). The full genome phylogenetic analysis confirmed that worldwide reported CanineCV strains were separated into four distinct genotypes in addition to a European origin of the South American CanineCV strains. This study demonstrated the importance of continue surveillance of emerging viruses in canine populations and confirm for the first time the circulation and origin of CanineCV in Colombia.

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“…Canine Distemper virus infection presents as a potentially fatal multisystem disease that can involve the CNS; Only in South America have 4 lineages different from those already known circulating on the continent been described [6]; It has four clinical forms: Respiratory, digestive, cutaneous, nervous, which can appear together or separately, and their combinations.…”

Section: Symptomatologymentioning

confidence: 99%

Canine Distemper, Clinical Update, Based on our Medical Experience and Scientific Evidence

Palomino¹,

Lozano²,

Cruz³

et al. 2022

Act Sci VetSci

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The objective of this research is to provide the clinical update of the canine Distemper, based on our experience with medical practice and scientific evidence, to provide updated support to multidisciplinary medical teams, to describe, address, and identify the most useful methods For diagnosis, apply urgent therapies to try to reduce the high morbidity and mortality caused by this health phenomenon, and be able to predict, considering that it is the most aggressive among many of the pathologies that canines present today and other non-domestic species. It was investigated, between the months of September to December 2021, analyzing the data collected to have a current vision of the behavior of this lethal noxa.

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Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia

Cited by 11 publications

References 36 publications

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

RETRACTED: Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells

First detection and full genomic analysis of Canine Circovirus in CPV-2 infected dogs in Colombia, South America

Canine Distemper, Clinical Update, Based on our Medical Experience and Scientific Evidence

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