Physical Activity and Fatigue in Patients with Sarcoidosis

Bahmer, Thomas; Watz, Henrik; Develaska, Maria; Waschki, Benjamin; Rabe, Klaus F.; Magnussen, H; Kirsten, D; Kirsten, Anne-Marie

doi:10.1159/000481827

Cited by 25 publications

(38 citation statements)

References 37 publications

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“…The results of this study show that DL PA is decreased in adult patients with stage IV sarcoidosis and that SPD is significantly associated with VO 2 max. Our results are in agreement with three previous studies evaluating physical activity in patients with sarcoidosis . Kostorz et al evaluated the comorbidities associated with DL PA in 30 patients with sarcoidosis, albeit without precise radiological staging and found that the patients had walked a mean (±SD) SPD of 5214 (±2699).…”

Section: Discussionsupporting

confidence: 92%

“…However, it is important to note that Bahmer et al included only three patients with chronic sarcoidosis stage IV in their study cohort, which could explain the differences between their and our results. Indeed, the mean (±SD) SPD recorded in that study (7490 ± 3007) was higher than in our study (6395 ± 4119).…”

Section: Discussioncontrasting

confidence: 82%

“…In our study, multivariable analysis showed no correlation between SPD and resting functional parameters (DLco, FEV 1 , TLC, and FVC), and a correlation between SPD and exercise tolerance was detected only when the latter was evaluated by VO 2 max but not by the 6MWT. Finally, the study by Bahmer et al showed an association between SPD and 6MWT distance, fatigue score (Multidimensional Fatigue Inventory), and quality of life scores (St. George's Respiratory and SF‐12 questionnaires) . However, it is important to note that Bahmer et al included only three patients with chronic sarcoidosis stage IV in their study cohort, which could explain the differences between their and our results.…”

Section: Discussioncontrasting

confidence: 73%

“…We also found that total daily expenditure was correlated with FEV 1 . Bahmer et al found that FEV 1 was associated with the 6MWT distance but not with SPD in patients with sarcoidosis. However, the mean FEV 1 in that study was less severe than in our study.…”

Section: Discussionmentioning

confidence: 98%

“…Little is known about DL PA in patients with chronic sarcoidosis . Saligan showed a reduction in physical activity associated with fatigue, depressive symptoms, and a shorter distance in the 6‐minute walk test (6MWT), whereas Bahmer et al found a significant association with 6MWT distance and quality of life scores but only a weak association with fatigue . However, these studies examined patients with a variety of respiratory conditions, and relatively few of them had chronic fibrotic disease.…”

Section: Introductionmentioning

confidence: 99%

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Daily life physical activity in patients with chronic stage IV sarcoidosis: A multicenter cohort study

Froidure¹,

Kyheng²,

Grosbois³

et al. 2019

Health Science Reports

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Background and objectives Little is known about the consequences of chronic sarcoidosis on daily life physical activity (DLPA). The aim of this prospective study was to measure DLPA in patients with chronic sarcoidosis and to determine its relationship to clinical and functional parameters. Methods Fifty‐three patients with chronic sarcoidosis and 28 healthy control subjects were enrolled in this multicenter prospective study. Two markers of DLPA (number of steps walked per day [SPD]) and total daily energy expenditure (TEE) were assessed for five consecutive days with a physical activity monitor. Pulmonary function, aerobic capacity (maximal oxygen uptake [VO2max]), exercise capacity (6‐min walk test [6MWT]), and quality of life (self‐reported questionnaires) were also evaluated. Comparisons of DLPA parameters between the two groups were performed using an analysis of covariance adjusted for age, sex, and body mass index (BMI). Relationships between DLPA parameters and patient characteristics were assessed in multivariable linear regression models. Results Patients with sarcoidosis walked significantly fewer SPD than did the control subjects (6395 ± 4119 and 11 817 ± 3600, respectively; P < 0.001 after adjustment for age, BMI, and sex). TEE was not significantly different between patients with sarcoidosis and healthy controls (median [interquartile range]: 2369 [2004‐2827] and 2387 [2319‐2876] kcal/day, respectively, P = 0.054 adjusted for age, BMI, and sex). SPD showed significant positive correlations with 6MWT distance (Pearson's correlation, r = 0.32, 95% confidence intervals [95%CI] = 0.06, 0.55; P = 0.019), VO2max (r = 0.44, 95%CI = 0.17, 0.65; P = 0.002), and Visual Simplified Respiratory Questionnaire score (r = 0.44, 95%CI = 0.19, 0.64; P = 0.001), and a significant negative correlation with modified Medical Research Council questionnaire score (r = −0.38, 95%CI = −0.60, −0.10; P = 0.009). TEE was significantly correlated with BMI (r = 0.38, 95%CI = 0.13, 0.59; P = 0.004), forced expiratory volume in 1 second (r = 0.55, 95%CI = 0.33, 0.71; P < 0.001), total lung capacity (r = 0.44, 95%CI = 0.18, 0.64; P = 0.001), and forced vital capacity (r = 0.56, 95%CI = 0.34, 0.72; P < 0.001). In multivariable analysis, SPD remained associated only with VO2max. Conclusion Patients with chronic sarcoidosis appear to have reduced DLPA mainly because of compromised VO2max.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 82%

Section: Discussioncontrasting

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Daily life physical activity in patients with chronic stage IV sarcoidosis: A multicenter cohort study

Froidure¹,

Kyheng²,

Grosbois³

et al. 2019

Health Science Reports

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Sarkoidose und Berylliose

et al. 2022

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Physical Inactivity in Pulmonary Sarcoidosis

Cho

Vasudevan

Maddocks

et al. 2019

Lung

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Purpose Reduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with pulmonary sarcoidosis and investigate its relationship with lung function, exercise capacity, symptom burden, and health status. Methods Physical activity was assessed over one week in 15 patients with pulmonary sarcoidosis and 14 age-matched healthy controls with a tri-axial accelerometer (ActivPal™) and the International Physical Activity Questionnaire (IPAQ). All participants underwent pulmonary function tests, 6-min walk test (6MWT) and completed the Fatigue Assessment Scale (FAS), Medical Research Council (MRC) Dyspnoea Scale and the King’s Sarcoidosis Questionnaire (KSQ). Results Patients with sarcoidosis had significantly lower daily step counts than healthy controls; mean (SD) 5624 (1875) versus 10,429 (2942) steps ( p < 0.01) and a trend towards fewer sit-to-stand transitions each day ( p = 0.095). Only two patients (13%) self-reported undertaking vigorous physical activity (IPAQ) compared to half of healthy individuals ( p < 0.01). Daily step count was significantly associated with 6MWT distance in sarcoidosis ( r = 0.634, p = 0.01), but not with forced vital capacity ( r = 0.290), fatigue ( r = 0.041), dyspnoea ( r = −0.466) or KSQ health status ( r = 0.099–0.484). Time spent upright was associated with fatigue ( r = −0.630, p = 0.012) and health status (KSQ Lung scores r = 0.524, p = 0.045), and there was a significant correlation between the number of sit-to-stand transitions and MRC dyspnoea score ( r = −0.527, p = 0.044). Conclusion Physical activity is significantly reduced in sarcoidosis and is associated with reduced functional exercise capacity (6MWD). Fatigue, exertional symptoms and health status were more closely associated with time spent upright and the number of bouts of physical activity, as compared to step counts. Further studies are warranted to identify the factors that determine different physical activity profiles in sarcoidosis. Electronic supplementary material The online version of this article (10.1007/s00408-019-00215-6) contains supplementary material, which is available to authorized users.

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Physical Activity and Fatigue in Patients with Sarcoidosis

Cited by 25 publications

References 37 publications

Daily life physical activity in patients with chronic stage IV sarcoidosis: A multicenter cohort study

Daily life physical activity in patients with chronic stage IV sarcoidosis: A multicenter cohort study

Sarkoidose und Berylliose

Physical Inactivity in Pulmonary Sarcoidosis

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