Physical activity as a risk factor for osteoarthritis of the knee

Development of a questionnaire for identification of the risk factors for osteoarthritis of the knees in developing countries. A pilot study in Iran and Bangladesh. An ILAR–COPCORD phase III study

“…A systemic review of knee OA literature 1–3,19–57 generated several items: epidemiologic association of pain in OA knee 19 and prognostic factors of cartilage loss, 20–22 obesity, 23–32 level of regular physical activity and high physical workload, 33–37 sex and sex hormone, 38,44 squatting and knee‐bending, 45 occupational physical activity, 46,47,48 and progression of primary generalized OA to secondary OA of knee 49 . In total, 53 items were generated (Table 1).…”

“…A preliminary APLAR‐COPCORD English questionnaire including items 1 through 37 was developed through repeated exchange of ideas and discussion. The ‘level of physical activity’ was classified by metabolic equivalents (METs) 33–37 as used in the guidelines for the data processing and analysis of the ‘International Physical Activity Questionnaire’ (short form) 50…”

Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort

“…While studies have shown that BMI and occupational activity are independently associated with kOA risk in a multiplicative model [6,7,18,19], only one has shown evidence for a positive multiplicative interaction [6]. Studies examining both physical activity and BMI are less convincing [20-25]; only one found evidence of a multiplicative interaction [26] and some report no evidence of an association between physical activity and kOA independent of BMI [23,25]. Many of these studies have been retrospective or case–control [6,7,18,20,22], potentially suffering from differential recall bias which would inflate associations.…”

“…Studies examining both physical activity and BMI are less convincing [20-25]; only one found evidence of a multiplicative interaction [26] and some report no evidence of an association between physical activity and kOA independent of BMI [23,25]. Many of these studies have been retrospective or case–control [6,7,18,20,22], potentially suffering from differential recall bias which would inflate associations. The timing of exposure may also be important.…”

Die Beanspruchung des Kniegelenkes durch Kniebeugung als Präarthrose

“…Die Gruppenzuordnung ist problematisch, da nur das Berufsbild, nicht jedoch das Ausmaß der Kniegelenksbelastung erfasst worden ist.Keinen Zusammenhang stellten Bagge et al[7], Grifka[40,41], Günther et al[45], Sairanen et al[97], Sahlström et al[96] und Wickström et al[112] zwischen Berufsarbeit und Gonarthrose fest. Imeokparia et al[56] fanden nur bei Frauen eine Korrelation von Arthroseinzidenz und "high physical activity" und hielten es für möglich, dass diese Korrelation hormonell bedingt sei. Von diesen Publikationen wurden nur zwei in der wissenschaftlichen Begründung für die Berufskrankheit "Gonarthrose …" erwähnt.In einer radiologischen Längsschnittstudie bei Patienten mit Gonarthrose (zwölf Jahresverläufe bei 46-bis 68-Jährigen; Gonarthrose Grad II bis IV nach Kellgren) stellten Schouten et al[99] fest, dass die Zunahme des Knorpelverlustes nicht mit "occupation related factors" korreliert ist.…”