Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study

Frutos-Lucas, Jaisalmer de; López‐Sanz, David; Zuluaga, Pilar; Rodríguez-Rojo, Inmaculada Concepción; Luna, Raúl; López, María Eugenia; Delgado-Losada, María Luisa; Marcos, Alberto; Barabash, Ana; López-Higes, Ramón; Maestú, Fernando; Fernández, Alberto

doi:10.1016/j.clinph.2018.06.026

Cited by 24 publications

(33 citation statements)

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“…In a previous publication, we reported that greater self-reported PA was signi cantly associated with greater alpha peak frequencies in older adults. Moreover, we were able to observe that such relationship remained signi cant only among E3/E3, although the small sample size in the E3/E4 group did not allow us to reach a de nite conclusion (de Frutos-Lucas et al, 2018). In this study, taking a different approach, we have been able to detect a positive relationship between objectively measured PA (in terms of total volume) and power in the alpha band in a cluster comprising mainly occipital and parietal regions, which are classic sources of this brain rhythm.…”

Section: Discussionmentioning

confidence: 71%

“…It is crucial to understand whether individuals who are more likely to develop AD can also bene t from a more active lifestyle. We have previously shown that highly active older adults (age 60 -80) present with higher alpha peak frequencies, although this relationship only existed among ε4 non-carriers (Frutos-lucas et al, 2018).…”

Section: Introductionmentioning

confidence: 90%

“…A team of expert neuropsychologists ensured that individuals willing to participate met inclusion criteria. The detailed list of exclusion criteria have been detailed previously (de Frutos-Lucas et al, 2018). Participants were asked to provide signed informed consent.…”

Section: Participantsmentioning

confidence: 99%

“…Power in the alpha band has been the focus of attention in many studies targeting different stages of preclinical and prodromal AD, as well as clinically symptomatic AD. Alterations of this kind of activity have been detected in asymptomatic ε4 carriers (Frutos-lucas et al, 2018), in individuals with subjective cognitive decline (SCD) (López-Sanz et al, 2016) and mild cognitive impairment (MCI) (Garcés et al, 2013), and correlate with cognitive worsening. Power reduction in the alpha band is thought to be the result of cumulative synaptic damage, mostly of cholinergic connections, which impedes the synchronization of activity at higher frequencies (Ebert and Kirch, 1998;Osipova et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies suggest that PA triggers a series of neuroprotective mechanisms in the brain that effectively reduce AD risk and neuropathological burden (Brown et al, 2018;Erickson et al, 2012;Kennedy et al, 2017;Lindsay et al, 2002;Okonkwo et al, 2014). Additionally, previous literature has shown that both acute and chronic PA are associated with higher peak frequencies and power in the alpha band (Frutos-lucas et al, 2018;Gutmann et al, 2015;Kubitz and Pothakos, 1997). Less well-known is how risk factors for AD, such as increased age and APOE ε4 carriage, in uence this relationship.…”

Section: Introductionmentioning

confidence: 99%

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Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

Frutos-Lucas

Cuesta

Ramírez‐Toraño

et al. 2020

Preprint

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BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer’s disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated. RESULTS: We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and only younger adults exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure. CONCLUSION: PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 90%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

Frutos-Lucas

Cuesta

Ramírez‐Toraño

et al. 2020

Preprint

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Peak occipital alpha frequency mediates the relationship between sporting expertise and multiple object tracking performance

Mackenzie,

Baker,

Daly

et al. 2024

Brain and Behavior

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BackgroundMultiple object tracking (MOT) is often used as a lab‐based paradigm for investigating goal‐driven attention as an indicator for “real‐world” attention in tasks such as sport. When exploring MOT performance in the context of sporting expertise, we typically observe that individuals with sporting expertise outperform non‐sporting individuals. There are a number of general explanations for performance differences such as cognitive transfer effects; however, the potential neurophysiological mechanisms explaining the relationship between sporting expertise and performance differences in MOT are not clear. Based on the role occipital alpha (posterior oscillations usually around 8–12 Hz) has been shown to have in visuospatial attention, the aim of this study was to examine whether individual differences in occipital peak alpha frequency (PAF) mediate the relationship between sporting expertise and performance in two object tracking tasks: a standard MOT task and a visuomotor‐controlled object tracking task (multiple object avoidance [MOA]).MethodUsing electroencephalography (EEG), participants, who either played sport competitively or did not, had their posterior PAF measured at rest (eyes closed) across a 2‐min window. They completed the two tasks separately from the resting EEG measures.ResultsThose who engaged in sport performed better in the MOT and MOA tasks and had higher PAF. Higher PAF predicted superior MOT performance. The mediation analysis revealed that sporting individuals had significantly higher PAF, and this was in turn related to superior MOT performance.ConclusionsIt is suggested that PAF is a possible neurophysiological mediating mechanism as to why sporting individuals have superior MOT performance. There was no evidence that PAF mediated the relationship between sporting expertise and visuomotor MOA performance. Explanations and implications are discussed, and unanswered questions are proposed.

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M/EEG Hallmarks of Healthy and Pathological Aging

Chino,

de Frutos Lucas,

Antón-Toro

et al. 2024

Psychiatry and Neuroscience Update – Vol. V

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Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study

Cited by 24 publications

References 68 publications

Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

Peak occipital alpha frequency mediates the relationship between sporting expertise and multiple object tracking performance

M/EEG Hallmarks of Healthy and Pathological Aging

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