Physical Activity in the Management of Patients with Coronary Artery Disease

Backshall, James; Ford, Gary A.; Bawamia, Bilal; Quinn, Louise; Trenell, Michael I.; Kunadian, Vijay

doi:10.1097/crd.0000000000000032

Cited by 16 publications

(8 citation statements)

References 115 publications

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“…it has been reported ~350,000 patients with cHd succumb to mortality every year (1,2). cHd is one of the most common types of atherosclerotic organ disease (3). Many atherosclerotic processes are closely related to the occurrence of cHd, such as inflammation, oxidative stress, hemodynamic changes and endothelial cell damage (4).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4

Huang

Hong

et al. 2020

Mol Med Report

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coronary heart disease (cHd) is the leading cause of human morbidity and mortality worldwide. Microrna (mirna) profiling is an innovative method of identifying biomarkers for many diseases and may be a powerful tool in the diagnosis and treatment of cHd. The present study aimed to analyze the effects of miRNA (miR)-381 on the inflammatory damage of endothelial cells during cHd. a total of 21 patients with cHd and 21 healthy control patients were enrolled in this study. reverse transcription-quantitative PCR, western blotting and immunofluorescence assays were conducted to examine the expression levels of mir-381, c-X-c chemokine receptor type 4 (cXcr4), Bcl-2, Bax, cleaved-caspases-3 and-9, p38, erK1/2 and JnK. cell Counting Kit-8, EdU and flow cytometry experiments were performed to evaluate cell proliferation and apoptosis. an ELISA was adopted to determine the expressions of inflammatory factors (interleukins-8,-6 and-1β, and tumor necrosis factor-α). in addition, a dual-luciferase reporter assay was used to determine the relationship between mir-381 and cXcr4. decreased mir-381 expression and increased cXcr4 expression in the plasma were observed in the cHd group compared with the normal group, which indicated a negative relationship between mir-381 and cXcr4. overexpression of mir-381 significantly promoted the proliferation and inhibited the apoptosis of oxidized low-density lipoprotein (oX-ldl)-induced human umbilical vein endothelial cells (HuVecs) through mitogen-activated protein kinase pathway by targeting and inhibiting cXcr4. Furthermore, overexpression of miR-381 reduced the release of inflammatory factors in oX-ldl-induced HuVecs. By contrast, reduced expression of mir-381 exerted the opposite effects, which were subsequently reversed by silencing cXcr4 expression. results from the present study indicated that mir-381 was a cHd-related factor that may serve as a potential molecular target for cHd treatment.

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Section: Introductionmentioning

confidence: 99%

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4

Huang

Hong

et al. 2020

Mol Med Report

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“…Functional capacity is a potentially modifiable risk factor in patients undergoing TAVR. Exercise interventions have been shown to be effective with mortality benefits in cardiac patients with coronary disease and congestive heart failure 12‐15 . The effect of a structured exercise program in patients with severe aortic stenosis will be addressed in the PERFORM‐TAVR trial (Protein and Exercise to Reverse Frailty in Older Men and women undergoing TAVR).…”

Section: Discussionmentioning

confidence: 99%

Prognostic implications of baseline 6‐min walk test performance in intermediate risk patients undergoing transcatheter aortic valve replacement

Sathananthan

Finn

Wood

et al. 2020

Cathet Cardio Intervent

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Background: While slow gait speed is known to be associated with poor outcomes in patients at high surgical risk who undergo transcatheter aortic valve replacement (TAVR), the prognostic significance of slow gait speed in intermediate risk TAVR patients is poorly understood. Objectives: We assessed the association between baseline 6-min walk test (6MWT) performance and both 2-year mortality and health status in intermediate risk patients undergoing TAVR as a part of the PARTNER II/S3i studies. Methods: The association of baseline 6MWT with mortality over 2-years after TAVR was examined using Cox regression; both unadjusted and adjusted for age, left ventricular ejection fraction, coronary artery disease, pulmonary disease, renal insufficiency, and STS score. Patients were divided into four groups according to baseline 6MWT: unable to walk and in three equal tertiles of slow, medium, and fast walkers. Among surviving patients, improvement in 6MWT and quality of life were compared. Results: Among 2,037 intermediate risk TAVR patients (mean age 81.7 years, STS score 5.6%), 8.2% were unable to walk. Baseline 6MWT was associated with allcause mortality over 2 years (Hazard ratio (HR) 0.87 per 50 m, 95% confidence interval [CI] 0.83 to 0.92, p < .0001). Among surviving patients, the adjusted absolute change in 6MWT at 2 years improved for patients unable to walk (+134.1 m, 95% CI 102.1 to 166 m, p < .0001) and slow walkers (+60.5 m, 95% CI 42.8 to 78.2 m, p < .0001), but was unchanged for medium walkers (−7.3 m, 95% CI −24.3 to 9.6 m, p = .4), and declined for fast walkers (−41.3 m, 95% CI −58.7 to −23.9 m, p < .0001).

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“…O tratamento não medicamentoso é considerado pelo menos tão efetivo quanto o uso de medicações (7) . Um dos aspectos primordiais desse tratamento é a realização de exercícios físicos regulares, que se configuram como elemento indispensável na reabilitação cardíaca após o evento isquêmico (25) .…”

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Percepção de homens após infarto agudo do miocárdio

Vieira¹,

Souza²,

Cavalcante³

et al. 2017

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Physical Activity in the Management of Patients with Coronary Artery Disease

Cited by 16 publications

References 115 publications

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4

Protective effect of microRNA‑381 against inflammatory damage of endothelial cells during coronary heart disease by targeting CXCR4

Prognostic implications of baseline 6‐min walk test performance in intermediate risk patients undergoing transcatheter aortic valve replacement

Percepção de homens após infarto agudo do miocárdio

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