Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease

Fazeli, Pariya L; Marquine, María J.; Dufour, Catherine A.; Henry, Brook L.; Montoya, Jessica L.; Gouaux, Ben; Moore, Raeanne C.; Letendre, Scott; Woods, Steven Paul; Grant, Igor; Jeste, Dilip V.; Moore, David J.

doi:10.1007/s10461-015-1024-z

Cited by 71 publications

(52 citation statements)

References 55 publications

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“…In a cross-sectional study of 335 adults with HIV, Dufour and colleagues (2013) found that those who exercised were less likely to have neurocognitive impairment compared to those who did not exercise (odds ratio = 2.63, p < 0.05). Similar findings have been found in older adults with HIV (Fazeli et al, 2015). …”

Section: Lifestyle Factors Brain Health and Cognitionsupporting

confidence: 89%

Perceptions of Brain Health and Cognition in Older African Americans and Caucasians With HIV: A Focus Group Study

Vance¹,

Gakumo²,

Childs³

et al. 2017

Journal of the Association of Nurses in AIDS Care

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As people age with HIV, cognitive problems may become more prevalent and severe, but lifestyle behaviors (i.e., physical activity) have been shown to protect brain health and cognition. We examined the perceptions that older adults living with HIV have about protecting and improving brain health and cognition through lifestyle behaviors. Qualitative data were analyzed from 4 focus groups (N = 30) of African Americans and Caucasians living with HIV and at least 50 years of age. An open-coding scheme using conventional content analysis was employed. Two results were found. First, many older adults with HIV in our study expressed a variety of cognitive complaints that interfered with daily function. Second, these participants reported few specific ideas about how such health behaviors were important to their own brain health and cognition. Education interventions may help older adults with HIV learn to improve and protect brain health and cognition as they age.

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Section: Lifestyle Factors Brain Health and Cognitionsupporting

confidence: 89%

Perceptions of Brain Health and Cognition in Older African Americans and Caucasians With HIV: A Focus Group Study

Vance¹,

Gakumo²,

Childs³

et al. 2017

Journal of the Association of Nurses in AIDS Care

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“…Moreover, work by our group among older adults living with HIV has shown that active lifestyles (including PA) are associated with better cognition and that PA is associated with better cognition and everyday functioning among older adults living with HIV [39,40]. Neuroimaging work has recently revealed that those who are physically active, as opposed to sedentary, have better executive functioning scores, and executive functioning was significantly associated with larger putamen volumes in adjusted models [40,41].…”

mentioning

confidence: 87%

A Longitudinal Analysis of the Impact of Physical Activity on Neurocognitive Functioning Among HIV-Infected Adults

et al. 2016

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Higher levels of physical activity (PA) have been linked to better neurocognitive functioning in many populations. The current study examines the longitudinal association between PA and neurocognitive functioning among HIV-infected and HIV-uninfected persons. Community-dwelling adults (N = 291) self-reported level of PA and completed a comprehensive neuropsychological battery at two to four study visits (Mean follow-up time = 2.6 years). Participants were divided into three PA groups: ''No PA'' (no PA at any visit), ''consistent PA'' (PA at C50% of visits), and ''inconsistent PA'' (PA \ 50% of visits). A mixed effect model, adjusting for significant covariates showed that all PA groups had statistically significant, yet modest, neurocognitive decline over time; and, the consistent PA group began with, and maintained, significantly better neurocognitive function compared to the other two PA groups. This effect was evident among both HIV-uninfected and HIV-infected persons, despite the fact that HIV-infected persons showed lower baseline neurocognitive function. PA is a modifiable lifestyle behavior that may help to protect against neurocognitive impairment regardless of HIV status, however, given the proportion of HIV-infected individuals who evidence neurocognitive difficulties, a focus on increasing PA seems warranted.Resumen La actividad física (AF) ha sido asociada con un mejor funcionamiento neurocognitivo en varios grupos. Este estudio examinó la asociación longitudinal entre la AF y el funcionamiento neurocognitivo en personas con y sin infección del VIH. Adultos viviendo en la comunidad (N = 291) proporcionaron información acerca de sus niveles de AF y completaron una batería neuropsicológica exhaustiva. Los participantes completaron entre dos y cuatro visitas relacionadas con el estudio (tiempo de seguimiento promedio = 2,6 años) y fueron divididos en tres grupos de AF: ''Ninguna AF'' (Ninguna AF durante todas las visitas del estudio), ''AF Consistente'' (AF durante 50% o más de las visitas del estudio), y ''AF Inconsistente'' (AF durante menos del 50% de las visitas del estudio). Un modelo estadístico mixto, ajustando por el efecto de variables externas, indicó que hubo una reducción estadísticamente significativa, pero poco pronunciada, en el funcionamiento neurocognitivo en todos los grupos. Además, el grupo con AF Consistente demostró un mejor funcionamiento neurocognitivo en comparación con los otros dos grupos de AF al comienzo del estudio, el cual se mantuvo durante el seguimiento. A pesar de que las personas con VIH demostraron un funcionamiento neurocognitivo más bajo al comienzo del estudio que las personas sin VIH, el efecto de AF fue demostrado en los dos grupos. Es importante recalcar que la AF es un factor de vida modificable que podría proteger contra los daños neurocognitivos independientemente de si las personas tienen o no VIH. Dada la proporción de personas con VIH que demuestran problemas neurocognitivos relacionados con esta enfermedad, será importante enfocar los esfuerzos ...

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“…For example, increasing physical activity by as little as 500 steps per day improves performance in older adults on measures such as the Trail Making Test B (Rosenberg et al, 2012). A recent cross-sectional study indicated that PLWH with neurocognitive impairment ( n = 43) exhibited significantly less moderate physical activity (weekly minutes of moderate-intensity physical activity reported on the International Physical Activity Questionnaire) compared to cognitively intact PLWH ( n = 57; Fazeli et al, 2015); however, the effect of a physical activity intervention on HAND has not been assessed. In addition, physical activity interventions applied in the HIV population have typically required rigorous activity (e.g., running on a treadmill; O’Brien, Nixon, Tynan, & Glazier, 2010) and significant participant effort (traveling to a gym several times a week), which may not be feasible for many individuals.…”

mentioning

confidence: 99%

Preliminary Findings Describing Participant Experience With iSTEP, an mHealth Intervention to Increase Physical Activity and Improve Neurocognitive Function in People Living With HIV

Henry¹,

Moore²

2016

Journal of the Association of Nurses in AIDS Care

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We assessed the feasibility and acceptability of using text messages to monitor and encourage physical activity in the first 21 participants enrolled in an ongoing randomized controlled trial evaluating a 16-week Short Message Service/Multimedia Message Service (SMS/MMS) intervention (iSTEP) designed to increase moderate physical activity and improve neurocognition in persons with HIV-associated neurocognitive disorders (HAND; iSTEP, n = 11; control group, n = 10). Data were collected during the intervention and from interviews conducted at the 16-week post-intervention visits. Text message response rates for both iSTEP and control participants were high (89% and 85%, respectively). Pedometer self-monitoring, step count goals, and milestone achievement texts were reported to facilitate physical activity. All iSTEP participants (100%) and 70% of control participants indicated that they would recommend the study to other people living with HIV. The results indicate that it is feasible to administer an SMS/MMS physical activity intervention to persons with HAND.

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Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease

Cited by 71 publications

References 55 publications

Perceptions of Brain Health and Cognition in Older African Americans and Caucasians With HIV: A Focus Group Study

Perceptions of Brain Health and Cognition in Older African Americans and Caucasians With HIV: A Focus Group Study

A Longitudinal Analysis of the Impact of Physical Activity on Neurocognitive Functioning Among HIV-Infected Adults

Preliminary Findings Describing Participant Experience With iSTEP, an mHealth Intervention to Increase Physical Activity and Improve Neurocognitive Function in People Living With HIV

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