Physical Basis for Poloxamer Interactions

The rheological anomaly in water-silicate systems: a possible thermodynamic explanation

“…The latter include aqueous solutions of methylcellulose [6,7], of hydroxypropyl methylcellulose [6,8], of some block copolymers based on polyalkylene glycols, N-substituted polyacrylamides, polyphosphazenes, etc. [9,10]. However, in all these cases the anomaly has a completely different mechanism that is not associated with the polymerization of ions [6,9,11].…”

“…[9,10]. However, in all these cases the anomaly has a completely different mechanism that is not associated with the polymerization of ions [6,9,11].…”

Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice

“…blocks (Schmolka, 1994). 5 pluronics, PEG, and 3 other PEG-like agents with a hydrophobe moiety, were tested here (Table 1).…”

“…(i) PLU markedly reduces cell loss and improves the growth of cells in culture (Swim and Parker, 1960), possibly because it strengthens the cell membranes (Zhang et al, 1992). The polyoxypropylene hydrophobe, not present in PEG, adheres to the hydrophobic area of the damaged cell membrane (Schmolka, 1994). PLU can thus plug holes, or facilitate membrane resealing (AlRubeai et al, 1993;Togo et al, 1999).…”

“…PLU has a long and safe history of clinical applications, and has been given i.v. to several hundred patients (Schmolka, 1994). Based on body area, the protective dose in rats would translate to 20 -40 g d -1 in humans.…”