Physical conditioning decreases norepinephrine-induced vasoconstriction in rabbits. Possible roles of norepinephrine-evoked endothelium-derived relaxing factor.

Chen, Hsiun‐ing; Li, Hsing-Tan; Chen, Chien-Chih

doi:10.1161/01.cir.90.2.970

Cited by 47 publications

(41 citation statements)

References 28 publications

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“…Similar results were reported with norepinephrine in several arteries, such as rabbit aorta (Chen et al, 1994), pig coronary artery (Parker et al, 1994), rat abdominal aorta (Delp et al, 1993;Spier et al, 1999), and rat thoracic aorta (Izawa et al, 1996). Repeated swimming exercise also reduces contractile activity to phenylephrine in isolated rat aorta (Jansakul, 1995).…”

Section: Discussionsupporting

confidence: 79%

“…Occurrence of repeated exercise-induced reductions in vascular responsiveness to norepinephrine were described in rat aorta (Delp et al, 1993;Jansakul, 1995;Spier et al, 1999), rabbit aorta (Chen et al, 1994) and pig coronary artery (Parker et al, 1994), but were not observed in endothelium-denuded arteries, supporting the idea of an endothelial role in the exercise-induced reduction of vascular responsiveness.…”

Section: Discussionmentioning

confidence: 89%

“…This local modulation of sympathetic agonist-induced vasoconstriction may be influenced by physical exercise. After exercise training, reductions in the vasomotor activity of norepinephrine have been reported to occur in several arteries, such as rabbit aorta (Chen et al, 1994), pig coronary artery (Parker et al, 1994), rat abdominal aorta (Delp et al, 1993;Spier et al, 1999), and rat thoracic aorta (Izawa et al, 1996). Repeated swimming exercise also reduces contractile responses to phenylephrine in the isolated rat aorta (Jansakul, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Phenylephrine-induced vasoconstriction of the rat superior mesenteric artery is decreased after repeated swimming

Chies

Oliveira²,

Pereira³

et al. 2004

J. Smooth Muscle Res.

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This study was performed to determine the effect of forced swimming on the vascular responsiveness of the rat superior mesenteric artery to phenylephrine, focusing on the involvement of locally produced substances. Repeated but not single sessions of forced swimming exercise reduced the vasoconstrictor potency of phenylephrine in the studied arteries, regardless of the presence of intact endothelium. No significant changes were observed in the maximal response to phenylephrine. Treatment with indomethacin (1 µM) did not affect the exercise-induced reduction in vascular responsiveness to phenylephrine. However, the reduction of vascular reactivity to phenylephrine due to repeated exercise was no longer observed after treatment with N G -monomethyl-Larginine (L-NMMA, 100 µM). The results suggest that repeated exercise reduces vasomotor responses to phenylephrine in rat superior mesenteric arteries through a nonendothelial nitric oxide (NO)-related mechanism.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phenylephrine-induced vasoconstriction of the rat superior mesenteric artery is decreased after repeated swimming

Chies

Oliveira²,

Pereira³

et al. 2004

J. Smooth Muscle Res.

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show abstract

“…However, in spite of the disagreement among findings with regard to the acute effect of exercise on vasoconstriction response to norepinephrine, it seems to be a consensus that one of the chronic beneficial effects of aerobic exercise is the attenuation of adrenergic vasoconstriction (Oltman et al, 1992;Chen et al, 1994;Spier et al, 1999;McAllister et al, 2005), which presents important clinical relevance, since this response is increased in the majority of circulation system pathologies and cardiovascular risk factors (Stepp and Frisbee, 2002;Ajay and Mustafa, 2006; Koida et al, 2006;Lesniewske et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, other studies (Chen et al, 1994;Delp and Laughlin, 1997;Clarkson et al, 1999;Minami et al, 2002;Kobayashi et al, 2003;Meyer et al, 2006;) have revealed that aerobic exercise training is very efficient for prevention and for non-pharmacological treatment of these cardiovascular diseases, improving endothelial function and attenuating adrenergic vasoconstrictor response in both healthy individuals and individuals who have this vasomotor response altered. This effect of exercise training observed on arterial vasomotion is very consistent in the scientific community.…”

Section: Introductionmentioning

confidence: 99%

A single bout of moderate-intensity exercise increases vascular NO bioavailability and attenuates adrenergic receptor-dependent and -independent vasoconstrictor response in rat aorta

Bechara

Tanaka

Santos

et al. 2008

J. Smooth Muscle Res.

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The present study investigated the effect of one bout of moderate-intensity exercise on the adrenergic receptor-dependent and -independent vasoconstrictor response in rat aortas, and the role of nitric oxide (NO) bioavailability on these vasomotor responses. One group of rats was submitted to a 60 min of exercise at approximately 60% of maximal exercise capacity on a treadmill (exercise group) and the other one was placed in the treadmill without running (control group). Immediately after this period, both groups were euthanized and the thoracic aorta was removed to evaluate the vasoconstrictor response to norepinephrine and potassium chloride, and to evaluate the vascular nitrite and nitrate concentration. One bout of exercise attenuated the maximal contractile response to both norepinephrine and potassium chloride compared to control group. These differences on vascular reactivity were not observed in endothelium-denuded aortic rings and aortic rings pre-incubated with a nitric oxide synthesis inhibitor. Additionally, exercise group increased NO bioavailability (nitrite and nitrate concentration) as compared to control group. These results demonstrate that one bout of moderate-intensity exercise is able to attenuate adrenergic receptor-dependent and -independent vasoconstrictor response in rat aorta, mainly by increasing vascular NO bioavailability.

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Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta

et al. 2002

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Chronic exercise upregulates endothelial nitric oxide synthase (eNOS) gene expression. Whether the expression of inducible nitric oxide synthase (iNOS) is affected by exercise is unknown. We therefore investigated the effects of chronic exercise on iNOS and eNOS expression in isolated rat aortic endothelial and smooth muscle cells separately. Five-week-old male Wistar rats were randomly divided into control and exercise groups. After 10 weeks of running training, animals were sacrificed under ether anesthesia. The standard curve quantitative competitive reverse transcriptase-polymerase chain reaction method was used to quantify NOS mRNA expression in isolated endothelial/smooth muscle cells. To evaluate the functional role of iNOS, we examined phenylephrine-induced vascular responses with or without pretreatment with aminoguanidine. We found that (1) expression of iNOS and eNOS mRNA in endothelial cells was increased by chronic exercise and (2) chronic exercise blunted phenylephrine-induced vascular responses, probably by increasing NO release via iNOS. Our results show that chronic exercise increases both iNOS and eNOS gene expression in endothelium. These alterations may be partially responsible for the change in vascular response after exercise.

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Physical conditioning decreases norepinephrine-induced vasoconstriction in rabbits. Possible roles of norepinephrine-evoked endothelium-derived relaxing factor.

Abstract: Our data suggest that exercise training may decrease NE-induced vasoconstrictive response and may increase NE-stimulated EDRF release.

Cited by 47 publications

References 28 publications

Phenylephrine-induced vasoconstriction of the rat superior mesenteric artery is decreased after repeated swimming

Phenylephrine-induced vasoconstriction of the rat superior mesenteric artery is decreased after repeated swimming

A single bout of moderate-intensity exercise increases vascular NO bioavailability and attenuates adrenergic receptor-dependent and -independent vasoconstrictor response in rat aorta

Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta

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