2024
DOI: 10.1101/2024.07.10.602459
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Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential

Alessandro Rabbito,
Omolade Otun,
Amos Fumagalli
et al.

Abstract: Chemokine receptor 4 (CXCR4) is a member of the chemokine receptor exclusively activated by the chemokine CXCL12. While CXCR4 regulates numerous physiological processes associated with cell migration and embryogenesis, its overexpression has been involved in various cancer types. Studies suggest that intracellular CXCR4 expression rather than CXCR4-operated signaling underlies its pro-tumorigenic functions. Given the role of GPCR interacting proteins in their trafficking and subcellular localization, we charac… Show more

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