Physical Mapping of Two Nested Fixed Inversions in the X Chromosome of the Malaria Mosquito Anopheles messeae

Soboleva, Evgenia S.; Kirilenko, Kirill M.; Fedorova, Valentina S.; Kokhanenko, Alina A.; Artemov, Gleb N.; Sharakhov, Igor V.

doi:10.1007/978-3-031-36911-7_6

Lecture Notes in Computer Science

2023

DOI: 10.1007/978-3-031-36911-7_6

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Physical Mapping of Two Nested Fixed Inversions in the X Chromosome of the Malaria Mosquito Anopheles messeae

Evgenia S. Soboleva,

Kirill M. Kirilenko,

Valentina S. Fedorova

et al.

Abstract: Fig. S1 -The cytogenetic map of polymorphic and fixed inversions between An. messeae/An. daciae and An. atroparvus (modified from Artemov et al., 2021). The X00 and X11 are polymorphic inversion arrangements in An. messeae and An. daciae. The An. atroparvus X chromosome has two fixed inversions in comparison with the X11 arrangement of An. messeae.

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2024

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Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe, Anopheles atroparvus and Anopheles messeae

Soboleva,

Kirilenko,

Fedorova

et al. 2024

Insects

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The Maculipennis subgroup of malaria mosquitoes includes both dominant malaria vectors and non-vectors in Eurasia. Understanding the genetic factors, particularly chromosomal inversions, that differentiate Anopheles species can provide valuable insights for vector control strategies. Although autosomal inversions between the species in this subgroup have been characterized based on the chromosomal banding patterns, the number and positions of rearrangements in the X chromosome remain unclear due to the divergent banding patterns. Here, we identified two large X chromosomal inversions, approximately 13 Mb and 10 Mb in size, using fluorescence in situ hybridization. The inversion breakpoint regions were mapped by hybridizing 53 gene markers with polytene chromosomes of An. messeae. The DNA probes were designed based on gene sequences from the annotated An. atroparvus genome. The two nested inversions resulted in five syntenic blocks. Only two small syntenic blocks, which encompass 181 annotated genes in the An. atroparvus genome, changed their position and orientation in the X chromosome. The analysis of the An. atroparvus genome revealed an enrichment of gene ontology terms associated with immune system and mating behavior in the rearranged syntenic blocks. Additionally, the enrichment of DNA transposons was found in sequences homologous to three of the four breakpoint regions. This study demonstrates the successful application of the physical genome mapping approach to identify rearrangements that differentiate species in insects with polytene chromosomes.

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Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe, Anopheles atroparvus and Anopheles messeae

Soboleva,

Kirilenko,

Fedorova

et al. 2024

Insects

Self Cite

View full text Add to dashboard Cite

show abstract

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Physical Mapping of Two Nested Fixed Inversions in the X Chromosome of the Malaria Mosquito Anopheles messeae

Cited by 1 publication

References 45 publications

Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe, Anopheles atroparvus and Anopheles messeae

Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe, Anopheles atroparvus and Anopheles messeae

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