Physico-Mechanical Performance Evaluation of Large Pore Synthetic Meshes with Different Textile Structures for Hernia Repair Applications

Abstract

This paper studied the relationship between the textile structure of warp knitted hernia repair meshes and their physico-mechanical properties to solve the problem of hernia patch application evaluation and clear the mechanism of hernia patch structure-performance for clinical application. Six different prototypes of large pore meshes were fabricated, including four kinds of meshes with different pore shapes: H (hexagonal), D (diamond), R (round) and P (pentagonal); and two kinds of meshes with inlays: HL (hexagonal with inlays) and DL (diamond with inlays), using the same medical grade polypropylene monofilament. All meshes were designed with the same walewise density and coursewise density. Then the influence of other structural parameters on the physico-mechanical properties of the meshes was analysed. The physico-mechanical properties of these meshes tested meet the requirements of hernia repair, except mesh DL, whose tear resistance strength (12.93 ± 2.44 N in the transverse direction) was not enough. Mesh R and P demonstrated less anisotropy, and they exhibited similar physico-mechanical properties. These four kinds of meshes without inlays demonstrated similar ball burst strength properties, but mesh HL and DL exhibited better ball burst strength than the others. All in all, uniform structures are expected to result in less anisotropy, and meshes with inlays, to some extent, possess higher mechanical properties. And the ratio of open loop number to closed loop number in a repetition of weave of fabric has marked effect on the physico-mechanical properties. Thus we can meet the demands of specific patients and particular repair sites by designing various meshes with appropriate textile structures.

Fabrication and Characterization of Composite Meshes Loaded with Antimicrobial Peptides

“…The average longitudinal and transverse strains exhibit almost the same value. 68 Therefore, as described before, 38 different PP meshes with appropriate textile structures could be used as the matrix to simulate the properties of different sites or layers of human abdominal wall.…”

“…Materials. The large-pore light-weight PP mesh was knitted and heat-set as previously described, 38 and mesh with round pore (R) was used in this study. PCL (M n = 80 000), GG (Phytagel), dimethyl sulfoxide (DMSO), and glutaraldehyde were supplied by Sigma-Aldrich (St. Louis, MO, USA).…”

Preparation and in Vitro Evaluation of New Composite Mesh Functionalized with Cationic Antimicrobial Peptide

“…The peptide synthesis and reverse-phase high performance liquid chromatography (RP-HPLC) analysis and purification process are described in the Supplementary Material. The matrix material used in this study was the large pore polypropylene mesh R we investigated before [37].…”

Fabrication, characterization and in vitro accelerated degradation of polypropylene/poly (glycolide-ε-caprolactone) warp-knitted hernia repair mesh

“…Bursting refers to the phenomenon in which the fabric expands and gradually destroys under the external force perpendicular to the fabric plane, is one of the key parameters used to evaluate the clinical applicability of the mesh. 30 When the mesh was implanted, it is susceptible to compressive pressure from the abdominal tissue if the patient takes some actions such as bending, walking, and coughing. The damage of mesh will result in the surgical failure and high recurrence rate.…”