Physicochemical characterization of the structure and desorption relationship of tioconazole-assembled gold nanoparticles investigated by density functional theory and Raman spectroscopy

Cho, Eun-Min; Ganbold, Erdene‐Ochir; Lam, Anh Thu N.; Singh, Dheeraj K.; Kim, Doseok; Yang, Sung Ik; Lee, So Yeong; Joo, Sang‐Woo

doi:10.1016/j.colsurfa.2015.09.017

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…2C shows the Raman spectrum with a vibrational band at 1420.9 cm −1 that is assigned to the imidazole ring, whereas the bands at 593.6, 693.5, 832.8, 1030.8 and 1590.9 are ascribed to those of γ (C 4 ClH 2 S) chlorothiophene ring. The bands at 398.3, 450.4, 666.2, 856.8, 1207.8, 1279.5, and 1347.7 cm −1 refer to the δ (C 6 H 3 Cl 2 ) dichlorophenyl ring [35].…”

Section: Resultsmentioning

confidence: 99%

New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms

Calvo

Álvarez

Lamas

et al. 2019

Journal of Pharmaceutical Analysis

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Tioconazole (TCZ), a broad-spectrum antifungal agent, has significant activity against Candida albicans and other Candida species, and therefore, it is indicated for the topical treatment of superficial mycoses. The main goal of this work is to report an exhaustive identification and characterization procedure to improve and facilitate the online quality control and continuous process monitoring of TCZ in bulk material and loaded in two different dosage forms: ovules and nail lacquer. The methodologies were based on thermal (differential scanning calorimetry (DSC), melting point, and thermogravimetry (TG)), spectroscopic (ultraviolet (UV), Raman, near infrared (NIR), infrared spectroscopy coupled to attenuated total reflectance (FTIR-ATR), and nuclear magnetic resonance (NMR)), microscopic and X-ray diffraction (XRD). The TCZ bulk powder showed a high crystallinity, as observed by XRD, with a particles size distribution (3–95 µm) resolved by microscopic measurements. TCZ melting point (82.8 °C) and a degradation peak centered at 297.8 °C were obtained by DSC and DTG, respectively. An unambiguous structure elucidation of TCZ was obtained by mono- and two- dimensional 1H and 13C NMR spectral data analysis. The FTIR-ATR, Raman and NIR spectra of both the raw material and the commercial products were analyzed and their characteristic bands were tabulated. The best methods for TCZ identification in ovules were DSC, TG, XRD, NIR and Raman, while NIR and FTIR-ATR were the most appropriate techniques to analyze it in the nail lacquer. DSC, TG, DRX, Raman, FTIR-ATR and NIR spectroscopy are effective techniques to be used in online process analysis, because they do not require sample preparation, and they are considerably sensitive to analyze complex samples.

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Section: Resultsmentioning

confidence: 99%

New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms

Calvo

Álvarez

Lamas

et al. 2019

Journal of Pharmaceutical Analysis

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“…Therefore, this study aims to utilize gold-silver alloy substrates in conjunction with SERS technology to achieve rapid detection of ractopamine. By comparing the drawbacks of traditional detection methods with the advantages of SERS technology, as well as the superiority of gold-silver alloy substrates over single gold or silver substrates, we will provide a new, efficient detection method for the field of food safety, contributing to the safeguarding of public health and food safety 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of Ractopamine by SERS coupled with size-tunable Au-Ag alloy

Yin,

Peng,

Chao

et al. 2024

Sensing for Agriculture and Food Quality and Safety XVI

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Excessive consumption of β-adrenergic agonists from livestock, poultry, or viscera can present serious health risks, potentially endangering lives. Surface-enhanced Raman scattering (SERS) provides a precise method for measuring levels of β-adrenergic agonists. This study involved collecting spectra of ractopamine aqueous solutions by synthesizing Au@Ag NPS alloy substrates. A linear relationship between the concentration of ractopamine (ranged from 1 to 10 mg/L) and SERS intensity. Automatic Whittaker Filter (AWF) algorithm was used to preprocess the Raman spectra to remove the fluorescence background. A linear regression model was established between the SERS intensity of different Raman characteristic peaks of ractopamine and the content of ractopamine solution. The established model had linear relationship with a correlation coefficient R 2 of 0.98 and RMSE of 0.332 mg/L. This method provides a new idea for the determination of ractopamine. This study is helpful to develop a simple, low-cost and easy-to-store SERS method for the detection of ractopamine based on Au@Ag NPS.

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An Overview of Nanomaterials: History, Fundamentals, and Applications

2023

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Physicochemical characterization of the structure and desorption relationship of tioconazole-assembled gold nanoparticles investigated by density functional theory and Raman spectroscopy

Cited by 5 publications

References 45 publications

New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms

New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms

Rapid determination of Ractopamine by SERS coupled with size-tunable Au-Ag alloy

An Overview of Nanomaterials: History, Fundamentals, and Applications

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