Physicochemical Evaluation and Antibacterial Activity of &lt;i&gt;Massularia acuminata&lt;/i&gt; Herbal Toothpaste

Adeleye, Olutayo Ademola; Bamiro, Oluyemisi Adebowale; Akpotu, Mark O.; Adebowale, Modupe; Daodu, John; Sodeinde, Mariam Adeola

doi:10.4274/tjps.galenos.2020.42966

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…A general tendency that can be observed for all toothpaste samples is a decrease in viscosity values with the increase in spindle speed. This observation is in accordance with data reported in the literature [78,79]. A desired viscosity range for toothpaste is typically 60,000-240,000 cps [80], although values do tend to vary across the scientific literature in accordance with proposed compositions.…”

Section: Discussionsupporting

confidence: 90%

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Dobrota,

Florea,

Racz

et al. 2024

Materials

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To address tooth enamel demineralization resulting from factors such as acid erosion, abrasion, and chronic illness treatments, it is important to develop effective daily dental care products promoting enamel preservation and surface remineralization. This study focused on formulating four toothpastes, each containing calcined synthetic hydroxyapatite (HAP) in distinct compositions, each at 4%, along with 1.3% birch extract. Substitution elements were introduced within the HAP structure to enhance enamel remineralization. The efficacy of each toothpaste formulation was evaluated for repairing enamel and for establishing the dynamic of the remineralization. This was performed by using an in vitro assessment of artificially demineralized enamel slices. The structural HAP features explored by XRD and enamel surface quality by AFM revealed notable restorative properties of these toothpastes. Topographic images and the self-assembly of HAP nanoparticles into thin films on enamel surfaces showcased the formulations’ effectiveness. Surface roughness was evaluated through statistical analysis using one-way ANOVA followed by post-test Bonferroni’s multiple comparison test with a p value < 0.05 significance setting. Remarkably, enamel nanostructure normalization was observed within a short 10-day period of toothpaste treatment. Optimal remineralization for all toothpastes was reached after about 30 days of treatment. These toothpastes containing birch extract also have a dual function of mineralizing enamel while simultaneously promoting enamel health and restoration.

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Section: Discussionsupporting

confidence: 90%

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Dobrota,

Florea,

Racz

et al. 2024

Materials

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“…The moisture content of the five tubes of toothpaste was acceptable to reach a favourable spreadability and viscosity (22). Bay leaf essential oil toothpaste showed less abrasiveness compared to the positive control.…”

Section: Discussionmentioning

confidence: 94%

“…It was discovered that the organoleptic parameters of the formulated bay leaf essential oil toothpaste were acceptable in terms of colour, taste, smell, and texture, despite the absence of colourant and flavouring. Meanwhile, the requirements of toothpaste based on organoleptic parameters are a clear and appealing colour, satisfying taste and smell, as well as good texture and consistency to be applied (22). According to the acidity (pH), the formulated toothpaste was at pH 6, which was within the acceptable and safe range of 4.5-10.5 (23).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of herbal gel toothpaste formulated using bay leaf essential oil on physicochemical characteristics and extrinsic stain removal

Annisa,

Harsini,

Murti

2023

J Herbmed Pharmacol

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Introduction: Bay (Syzygium polyanthum) leaf may be used as an extrinsic stain-removing agent in toothpaste. This study assesses the formula of bay leaf essential oil toothpaste in terms of physicochemical and extrinsic stain removal properties. Methods: Using a gel composition with varying quantities of bay leaf essential oil (0%, 0.125%, 0.25%, and 0.5% v/v), tubes of toothpaste were formulated. Commercial stain-removal toothpaste was used as a positive control. Five toothpastes were evaluated based on their organoleptic properties, pH, moisture content, foaming ability, abrasiveness, spreadability, gritty matter, and homogeneity. Extrinsic stain removal evaluation was carried out using 20 bovine teeth that were split into five groups of toothpaste (n=4). The specimens were tea-stained and submitted to simulated brushing. The colour difference (ΔE) was analysed to evaluate extrinsic stain removal using the parameter of CIE-Lab (Commision Internacional de l’Eclairage L*a*b). Using a chromameter, the L*a*b value of the teeth before and after brushing was used to measure the ΔE value. Data were analysed through one-way ANOVA with a confidence level of 95%. Results: All tubes of toothpaste tested met acceptable physicochemical parameter standards. The bay leaf essential oil toothpaste with 0.25% and 0.5% v/v concentrations, as well as commercial toothpaste, produced better ΔE values than the 0% v/v group. There were no statistically significant differences between bay leaf essential oil at 0.5% v/v and commercial toothpaste (P>0.05). Conclusion: Results demonstrated that bay leaf essential oil toothpaste had an extrinsic stain removal effect equivalent to positive control and promoted good physicochemical characteristics.

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“…Te phytochemical analysis of the aqueous and methanol extracts of E. cymosa leaf showed the presence of alkaloids, tannins, saponins, glycosides, and favonoids, while only the methanol extracts indicated the presence of steroids. Te presence of these phytochemicals in crude extracts of plants accounts for their biological activity as antibacterial agents [39,43], and they may also be involved in the reduction of silver ions to silver nanoparticles by acting as reducing and stabilizing agents [44][45][46]. Te synthesis of SNPs was observed visually as the colour of the reaction mixture changed indicating the formation of SNPs [47,48].…”

Section: Discussionmentioning

confidence: 99%

“…Drug-excipient compatibility testing is a necessary preformulation procedure during the development of new drug delivery systems to ensure safety, bioavailability, and stability of the drug product [46,58,59]. FTIR spectroscopy was used in this investigation.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Adeleye,

Aremu,

Iqbal

et al. 2023

Journal of Nanotechnology

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Objectives. The use of antibacterial drugs for the treatment of infections has been on for several decades but not without some challenges such as resistance. Research on natural products is on-going to mitigate this challenge. The aim of this study was to synthesize silver nanoparticles (SNPs) with aqueous and methanol extract of Ehretia cymosa leaf and to explore its antibacterial potentials in semisolid dosage delivery system as topical antibacterial cream and ointment. Methods. E. cymosa leaf was extracted by macerating in distilled water and methanol. The extracts were used to synthesize SNPs. SNPs were characterized and confirmed by visual observation, UV-visible spectroscopy, FTIR, atomic absorption spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. SNPs were used to formulate cream and ointment, and the antibacterial activity of the formulations was evaluated against Staphylococcus aureus and Escherichia coli. Results. Absorption band was observed at 450 nm for aqueous extract SNPs and 420 nm for methanol extract SNPs due to surface plasmon resonance. SNPs were agglomerated with the irregular size of 55 nm and 90 nm. The formulations had acceptable physicochemical properties with good drug-excipient compatibility. The antibacterial activity of cream formulations had a significantly ( p < 0.0001 ) higher antibacterial activity compared to ointment formulations. Both formulations with SNPs had higher antibacterial activity than ciprofloxacin. Conclusion. Cream and ointment formulations loaded with green synthesized E. cymosa leaf extract SNPs present a potential for a more efficient and effective antibacterial drug delivery to ameliorate the impact of antibacterial drug resistance.

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Physicochemical Evaluation and Antibacterial Activity of <i>Massularia acuminata</i> Herbal Toothpaste

Cited by 9 publications

References 16 publications

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Evaluation of herbal gel toothpaste formulated using bay leaf essential oil on physicochemical characteristics and extrinsic stain removal

Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

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