2010
DOI: 10.1016/j.jconrel.2010.03.011
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Physicochemical parameters affecting liposomal bisphosphonates bioactivity for restenosis therapy: Internalization, cell inhibition, activation of cytokines and complement, and mechanism of cell death

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Cited by 94 publications
(70 citation statements)
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“…F1 and F2 were selected for pursuing in vitro tests, as they presented high incorporation parameters and long circulating properties, respectively. Although similar incorporation parameters were achieved for formulation F4, it was not chosen for in vitro studies due to SA toxicity reported in the literature [58,59].…”
Section: Characterization Of Cuphen Liposomesmentioning
confidence: 99%
“…F1 and F2 were selected for pursuing in vitro tests, as they presented high incorporation parameters and long circulating properties, respectively. Although similar incorporation parameters were achieved for formulation F4, it was not chosen for in vitro studies due to SA toxicity reported in the literature [58,59].…”
Section: Characterization Of Cuphen Liposomesmentioning
confidence: 99%
“…[12] Both cationic liposomes and NPs have been shown to cause damage to the mitochondria in various cell types. [29] They can also activate the immune response through Toll-like receptor 4 (TLR4), expressed on monocytes and macrophages, by inducing pro-inflammatory cytokines [30] and type I interferon. [31] Alternative delivery vehicles with less toxicity and with an enhanced serum and plasma stability are therefore preferred.…”
Section: General Considerationsmentioning
confidence: 99%
“…This was without cells showing cytotoxicity and the lipoplexes displaying serum stability. [32] However, in vivo studies have shown that highly negatively charged anionic liposomes are readily removed from circulation by monocytes and macrophages of the MPS; [30] thus limiting the possible use of anionic liposomes as gene-/drug-delivery systems if the target site is beyond the MPS.…”
Section: General Considerationsmentioning
confidence: 99%
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“…A glicerin az egyik leggyakrabban használt stabilizátor, amit főként fehérjék mellett alkalmaznak, ráadásul gyógyszerkönyvi anyag is. 115 Az eredményeket az alábbi táblázat összegzi.…”
Section: A260unclassified