Physicochemical studies on the micellization of anionic surfactants in the presence of long alkyl chain ionic liquid

Tanwar, Lavkesh Kumar Singh; Banjare, Manoj Kumar; Sharma, Surbhi; Ghosh, Kallol K.

doi:10.1016/j.cplett.2021.138399

Cited by 8 publications

(4 citation statements)

References 45 publications

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“…To assess this, pDNA Onpattro LNPs were heated to 99 °C, followed by cooling for 20–30 min, with the addition of SDS to a final concentration of 8 mM. Critical micelle concentration for SDS and LDS is 8.3 mM and 8.5 mM, respectively, and approaching this concentration is important to get an adequate breakdown of the LNPs. The results showed an adequate breakdown of the LNPs with the formation of two distinct size distributions, indicating micelles (from ∼5 to ∼15 nm) and larger aggregates (from 200 to 1000 nm) with no size overlap with the original LNP peak (∼100 nm) (Figure S2C).…”

Section: Resultsmentioning

confidence: 99%

“…These verification studies were performed to ensure that our method was causing an adequate and consistent breakdown of LNPs, their lipid structures, and NA release for accurate analysis (Figure S2). To assess this, pDNA Onpattro LNPs were heated to 99 °C, followed by cooling for 20−30 min, with the addition of SDS to a final concentration 53 respectively, and approaching this concentration is important to get an adequate breakdown of the LNPs. The results showed an adequate breakdown of the LNPs with the formation of two distinct size distributions, indicating micelles (from ∼5 to ∼15 nm) and larger aggregates (from 200 to 1000 nm) with no size overlap with the original LNP peak (∼100 nm) (Figure S2C).…”

Section: Lnp Characterization Using the Traditionalmentioning

confidence: 99%

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Electrophoretic Microfluidic Characterization of mRNA- and pDNA-Loaded Lipid Nanoparticles

De Peña,

Zimmer,

Gutterman-Johns

et al. 2024

ACS Appl. Mater. Interfaces

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Lipid nanoparticles (LNPs) are clinically advanced nonviral gene delivery vehicles with a demonstrated ability to address viral, oncological, and genetic diseases. However, the further development of LNP therapies requires rapid analytical techniques to support their development and manufacturing. The method developed and described in this paper presents an approach to rapidly and accurately analyze LNPs for optimized therapeutic loading by utilizing an electrophoresis microfluidic platform to analyze the composition of LNPs with different clinical lipid compositions (Onpattro, Comirnaty, and Spikevax) and nucleic acid (plasmid DNA (pDNA) and messenger RNA (mRNA)) formulations. This method enables the high-throughput screening of LNPs using a 96or 384-well plate with approximate times of 2−4 min per sample using a total volume of 11 μL. The lipid analysis requires concentrations approximately between 10 9 and 10 10 particles/mL and has an average precision error of 10.4% and a prediction error of 19.1% when compared to using a NanoSight, while the nucleic acid analysis requires low concentrations of 1.17 ng/μL for pDNA and 0.17 ng/μL for mRNA and has an average precision error of 4.8% and a prediction error of 9.4% when compared to using a PicoGreen and RiboGreen assay. In addition, our method quantifies the relative concentration of nucleic acid per LNP. Utilizing this approach, we observed an average of 263 ± 62.2 mRNA per LNP and 126.3 ± 21.2 pDNA per LNP for the LNP formulations used in this study, where the accuracy of these estimations is dependent on reference standards. We foresee the utility of this technique in the high-throughput characterization of LNPs during manufacturing and formulation research and development.

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Section: Resultsmentioning

confidence: 99%

Section: Lnp Characterization Using the Traditionalmentioning

confidence: 99%

Electrophoretic Microfluidic Characterization of mRNA- and pDNA-Loaded Lipid Nanoparticles

De Peña,

Zimmer,

Gutterman-Johns

et al. 2024

ACS Appl. Mater. Interfaces

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“…The MI + IBU system has a greater impact on the PIL than MI + ASP. 46 3.1.1 Surface tension. Surface tension is a frequently employed technique for determining the characteristic properties of surface-active components.…”

Section: Study Of the Micellar Behavior Of Pil With MI And Nsaidsmentioning

confidence: 99%

Study of the molecular interaction of a phosphonium-based ionic liquid within myo-inositol and non-steroidal anti-inflammatory drugs

Banjare,

Banjare

2024

RSC Adv.

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“…It has been found that the hydrophobes of tetraalkyl ammonium salt are known to penetrate into the micellar core of the surfactant and have a tendency to make the micelle shrink and act as spacers between the surfactant head groups (Esan et al, 2015). Apart from this, in molten state, these salts also behave as ionic liquids and in this capacity, various multiapproach applications concentrating on the change in the behavior of aqueous surfactant solution with the incorporation of additives like electrolytes or drugs have been published in recent years (Pathania & Chauhan, 2020b; Tanwar et al, 2021). Therefore, in the present work, the changes in the physicochemical properties of CTAB in aqueous solution upon addition of R 4 N + Br − at different temperatures have been investigated by using conductometric technique and calculating various thermodynamic parameters which are useful to know about the thermal stability of these ternary systems.…”

Section: Introductionmentioning

confidence: 99%

Insight of molecular interactions between short‐chain tetraalkylammonium bromides and cetyltrimethylammonium bromide: A spectroscopic and thermodynamic approach

Chauhan

Negi

2023

J Surfact & Detergents

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The influence of tetraalkylammonium salts, viz., tetraethylammonium, tetrapropylammonium, and tetrabutylammonium bromides (0.005, 0.010, 0.015 mol kg−1) on the micellar behavior of aqueous solutions of the cationic surfactant cetyltrimethylammonium bromide (CTAB, 0.2–2 mmol kg−1) over the 298.15–313.15 K temperature range has been studied by conductometric method. From conductivity versus surfactant concentration plots, the critical micelle concentration (CMC) of CTAB has been determined, which shows that the tetraalkylammonium bromides promote the formation of CTAB aggregates. Further, from the temperature dependence of CMC values, the degree of ionization, the counterion binding constant along with some thermodynamic parameters of micellization, such as standard free energy change (), standard enthalpy change (), standard entropy change () have been calculated. From the values of , and , it has been concluded that our ternary system is both enthalpy as well as entropy controlled. Similar CMC values were obtained from UV–Visible spectrometry measurements, using pyrene as a probe at ambient temperature. Also 1H‐NMR and FTIR methods give a greater understanding of the molecular scale interactions between the tetraalkylammonium bromides and the cationic surfactant.

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Physicochemical studies on the micellization of anionic surfactants in the presence of long alkyl chain ionic liquid

Cited by 8 publications

References 45 publications

Electrophoretic Microfluidic Characterization of mRNA- and pDNA-Loaded Lipid Nanoparticles

Electrophoretic Microfluidic Characterization of mRNA- and pDNA-Loaded Lipid Nanoparticles

Study of the molecular interaction of a phosphonium-based ionic liquid within myo-inositol and non-steroidal anti-inflammatory drugs

Insight of molecular interactions between short‐chain tetraalkylammonium bromides and cetyltrimethylammonium bromide: A spectroscopic and thermodynamic approach

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