Physicochemical Surface Properties of Various Intraocular Lenses

Dick, H. Burkhard; Frohn, A.; Augustin, Albert J.; Wolters, Barbara; Pakuła, Tadeusz; Pfeiffer, Norbert

doi:10.1159/000055685

Cited by 19 publications

(17 citation statements)

References 23 publications

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“…The basis of the contact angle measurement lies in the fact that the spreading of a drop on a surface is related to physical-chemical forces between the liquid and the material [8]. The sessile-drop method in air was used to quantify wetting ability, an indicator of hydrophilicity.…”

Section: Methodsmentioning

confidence: 99%

Material Properties of Various Intraocular Lenses in an Experimental Study

et al. 2003

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Introduction: With the recent introduction of small-incision cataract surgery, requirements for intraocular lens (IOL) flexibility, strength and hydrophilicity have rapidly evolved. The IOL surface, however, remains a critical factor influencing uveal biocompatibility. Purpose: To objectively quantify factors of material properties of various IOLs using contact angle measurements, differential scanning calorimetry, dynamic-mechanical measurements and scanning electron microscopy. Material and Methods: In our study, 17 currently available IOLs were investigated using contact angle measurements to assess hydrophilicity and biocompatibility, as well as differential scanning calorimetry for the estimation of glass transition temperature. Mechanical capacity and flexibility were investigated using dynamic-mechanical measurements. Additional analysis of the IOL surface was performed using scanning electron microscopy. Results: The contact angle measurements of the studied IOLs revealed similar values within each group. The silicone IOLs had values between 106 and 119°. The PMMA IOLs were found to have a narrower range of values, between 73.2 and 75.5°. Lenses made of hydrogel had values between 59.2 and 69.1°. The heparin-modified surface showed the lowest contact angle of 56.5°. The glass transition temperature was determined by dynamic differential scanning calorimetry. The resulting values were between 118.8 and 113.5°C for PMMA IOLs, 15.5 and 14.0°C for acrylic IOLs, and –91.7 and –119.6°C for silicone IOLs. The dynamic-mechanical measurements revealed that PMMA lenses manifested characteristics similar to glass, whereas silicone lenses had characteristics similar to rubber. Acrylic lenses were between rubber and glass. Scanning electron microscopy revealed smooth dispersion of fibrin on hydrophobic IOLs and a relative lack of fibrin adhesion on hydrophilic materials. Conclusion: These results demonstrate that material properties of various IOL materials are consistent within classes of IOL materials. This suggests that the intraoperative and postoperative behavior of an IOL is predictable and related to its composition, thus allowing surgeons to choose IOLs more appropriate for different surgical situations and individual patient characteristics.

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Section: Methodsmentioning

confidence: 99%

Material Properties of Various Intraocular Lenses in an Experimental Study

et al. 2003

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“…Indeed, the hydrophobic character of the biomaterial surfaces studied is not investigated in these works. In fact only few authors have studied the wetting behavior of commercially available IOLs [11,12,13,14,15]. …”

Section: Discussionmentioning

confidence: 99%

“…It is a simple measurement technique whose results are easy to understand: a high water contact angle represents hydrophobicity and a low one, hydrophilicity [10]. Thus, IOLs made of silicone were found to have a water contact angle between 99 and 122° [12,13,14,15], which make them more hydrophobic than hydrophobic acrylic IOLs, which have a water contact angle around 73° (73.3 ± 2.4 for MA60BM) [14]. PMMA is also fairly water repellent, with a water contact angle of 70-75.5° [12,15] compared with hydrophilic acrylic polymers, which have a water contact angle of less than 69° [12].…”

Section: Discussionmentioning

confidence: 99%

“…The linear relationship is then extrapolated to cos θ = 1 to obtain the critical surface tension (γ C ) of each material [19]. In the literature, only two authors have determined the critical surface tensions (γ C ) of commercially available IOLs [13,14]. No other calculation approaches have been used so far in order to determine IOL surface energies.…”

Section: Discussionmentioning

confidence: 99%

“…Few authors have tried to determine the hydrophobicity parameters of commercially available intraocular lenses [11,12,13,14,15]. To investigate the wetting behavior of IOLs most of them have presented contact angle measurements between IOL surfaces and characterized test liquids: a high value contact angle would indicate a more hydrophobic surface [10].…”

Section: Introductionmentioning

confidence: 99%

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Calculation of Intraocular Lens Surface Free Energy and its Components from Contact Angle Measurements

et al. 2013

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One of the most important biomaterial characteristics involved in bacterial adhesion on intraocular lenses (IOLs) is hydrophobicity. We calculated the hydrophobicity parameters of IOLs made of 6 different materials (polymethylmethacrylate, PMMA, heparin surface-modified PMMA, HSM-PMMA, silicone, hydrophilic and hydrophobic acrylics and collamer). Values of IOL surface free energy components were determined from contact angle measurements, using the Fowkes, Owens-Wendt and Good-van Oss calculations. Contact angles were higher for silicone and hydrophobic acrylic materials and lower for collamer and hydrophilic acrylic materials. The values of IOL surface free energy components obtained with the 3 different calculations were homogenous. According to the Owens-Wendt calculation, the IOLs could be separated into dispersive implants (hydrophobic acrylic, silicone and PMMA) and polar implants (collamer, hydrophilic acrylic and HSM-PMMA).

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Effect of Hydrophobic Acrylic Monomers with Different Alkyl Side Chain Lengths on Reducing the Glistening of Hydrophobic Acrylic Intraocular Lens Materials

Kim,

Song

2024

ChemistrySelect

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Glistening is the condensation of water that forms within the intraocular lens (IOL) materials. In this study, a new approach was attempted to reduce the glistening of IOL materials by introducing hydrophobic acrylic monomers with different alkyl side chain lengths into the IOL materials. Various hydrophobic acrylic monomers such as butyl acrylate (BA), 2‐ethylhexyl acrylate (EHA), and dodecyl acrylate (DA) were copolymerized with a hydrophobic acrylic monomer, 2‐phenoxyethyl acrylate, respectively. In this process, we investigated the effect of the alkyl side chain lengths of hydrophobic acrylic monomers on the glistening of hydrophobic acrylic IOL materials. As the content of hydrophobic acrylic monomers (BA, EHA, and DA) increased, the glistening of IOL materials decreased significantly for all hydrophobic acrylic monomers. At the same content of hydrophobic acrylic monomers, the IOL material showed the least content of glistening when copolymerized with DA. However, the IOL material obtained using BA exhibited the largest content of glistening, indicating that the glistening reduction effect was large in the order of DA>EHA>BA. These findings show that the glistening of IOL materials decreases with increasing alkyl side chain lengths of hydrophobic acrylic monomers.

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Physicochemical Surface Properties of Various Intraocular Lenses

Cited by 19 publications

References 23 publications

Material Properties of Various Intraocular Lenses in an Experimental Study

Material Properties of Various Intraocular Lenses in an Experimental Study

Calculation of Intraocular Lens Surface Free Energy and its Components from Contact Angle Measurements

Effect of Hydrophobic Acrylic Monomers with Different Alkyl Side Chain Lengths on Reducing the Glistening of Hydrophobic Acrylic Intraocular Lens Materials

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