Physiological and biochemical responses to aluminum-induced oxidative stress in two cyanobacterial species

Hamed, Seham M.; Hassan, Sherif; Selim, Samy; Kumar, Amit; Khalaf, S.; Wadaan, Mohammed A. M.; Hozzein, Wael N.; AbdElgawad, Hamada

doi:10.1016/j.envpol.2019.05.036

Cited by 35 publications

(16 citation statements)

References 53 publications

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“…Scavenging system includes SOD which converts the superoxide radical to H 2 O 2 , and CAT and POX which trigger the conversion of H 2 O 2 to water and oxygen 51 . In line with our results, many studies reported that tolerance to heat stress is linked with an increase in antioxidant enzyme activities 29 , 32 , 54 . Also, Gür et al 46 reported increases in the activities of CAT at 45 °C, POX at 38 °C and ascorbate peroxidase (APX) at 38 °C and 45 °C in cotton ( Gossypium hirsutum L.).…”

Section: Discussionsupporting

confidence: 93%

“…ROS production is an important indicator of inducedantioxidant capacity in plants or microorganisms. The production of ROS in plants, algae and microorganisms is induced by a variety of environmental stressors, such as heat, salinity, drought, high light, heavy metals and UV radiation 20,[32][33][34][35][36] . Consequently, plant, protozoa and microbial cells use their antioxidant defense mechanisms to tackle ROS formation threats through enhancing their enzymatic and non-enzymatic antioxidant systems 32,[37][38][39][40] .…”

Section: Discussionmentioning

confidence: 99%

“…The production of ROS in plants, algae and microorganisms is induced by a variety of environmental stressors, such as heat, salinity, drought, high light, heavy metals and UV radiation 20 , 32 – 36 . Consequently, plant, protozoa and microbial cells use their antioxidant defense mechanisms to tackle ROS formation threats through enhancing their enzymatic and non-enzymatic antioxidant systems 32 , 37 – 40 . In this regard, a couple of studies have exploited microorganisms as a natural source of antioxidants.…”

Section: Discussionmentioning

confidence: 99%

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Heat stress as an innovative approach to enhance the antioxidant production in Pseudooceanicola and Bacillus isolates

Hassan

Hozzein

Mousa

et al. 2020

Sci Rep

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It is well known that the quality and quantity of bioactive metabolites in plants and microorganisms are affected by environmental factors. We applied heat stress as a promising approach to stimulate the production of antioxidants in four heat-tolerant bacterial strains (HT1 to HT4) isolated from Aushazia Lake, Qassim Region, Saudi Arabia. The phylogenetic analysis of the 16S rRNA sequences indicated that HT1, HT3 and HT4 belong to genus Bacillus. While HT2 is closely related to Pseudooceanicola marinus with 96.78% similarity. Heat stress differentially induced oxidative damage i.e., high lipid peroxidation, lipoxygenase and xanthine oxidase levels in HT strains. Subsequently, heat stress induced the levels of flavonoids and polyphenols in all strains and glutathione (GSH) in HT2. Heat stress also improved the antioxidant enzyme activities, namely, CAT, SOD and POX in all strains and thioredoxin activity in HT3 and HT4. While GSH cycle (GSH level and GPX, GR, Grx and GST activities) was only detectable and enhanced by heat stress in HT2. The hierarchical cluster analysis of the antioxidants also supported the strain-specific responses. In conclusion, heat stress is a promising approach to enhance antioxidant production in bacteria with potential applications in food quality improvement and health promotion.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Heat stress as an innovative approach to enhance the antioxidant production in Pseudooceanicola and Bacillus isolates

Hassan

Hozzein

Mousa

et al. 2020

Sci Rep

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“…In line with these findings, the AlCl 3 group revealed significantly higher expression levels of the amyloid precursor protein, which is considered the most important hallmark of AD (Hamed et al, 2019;Ghammraoui and Badano, 2020). However, a significant reduction in the expression level of the amyloid precursor protein gene in the group treated with QT-SPION demonstrated its effect on inhibition of AD development and progression caused by aluminum exposure.…”

Section: Discussionsupporting

confidence: 71%

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

et al. 2021

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Alzheimer’s disease (AD) is a neurodegenerative disease with cognitive impairment. Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant agents such as quercetin slow down AD progression, but the usage of this flavonoid has limitations because of its low bioavailability. We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have a better neuroprotective effect on AD than free quercetin and regulates the antioxidant, apoptotic, and APP gene, and miRNA-101. In this study, male Wistar rats were subjected to AlCl3, AlCl3 + QT, AlCl3 + SPION, and AlCl3 + QT-SPION for 42 consecutive days. Behavioral tests and qPCR were used to evaluate the efficiency of treatments. Results of behavioral tests revealed that the intensity of cognitive impairment was decelerated at both the middle and end of the treatment period. The effect of QT-SPIONs on learning and memory deficits were closely similar to the control group. The increase in expression levels of APP gene and the decrease in mir101 led to the development of AD symptoms in rats treated with AlCl3 while these results were reversed in the AlCl3 + QT-SPIONs group. This group showed similar results with the control group. QT-SPION also decreased the expression levels of antioxidant enzymes along with increases in expression levels of anti-apoptotic genes. Accordingly, the antioxidant effect of QT-SPION inhibited progression of cognitive impairment via sustaining the balance of antioxidant enzymes in the hippocampus of AD model rats.

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“…Reactive oxygen species production is one main signal to stimulate induced-antioxidant capacity in plants or microorganisms. The production of ROS by higher plants and algae is stimulated by various environmental stresses, for instance, exposure to high light levels ( Foyer et al, 1997 ), drought ( Melandri et al, 2020 ), heavy metals ( Okamoto et al, 2001 ; Hamed et al, 2017 , 2019 ), high salt concentrations ( Meneguzzo et al, 1999 ; Zhang et al, 2013 ), high temperature ( Rao et al, 1995 ), UV irradiation ( Malanga and Puntarulo, 1995 ), air pollutants including ozone ( Sharma et al, 1996 ), water stress ( Boo and Jung, 1999 ), and herbicides ( Tanaka, 1994 ). Accordingly, plant and algal cells exploit their defensive antioxidant mechanisms to tackle the threats posed by the generation of ROS.…”

Section: Discussionmentioning

confidence: 99%

Salinity Stress Enhances the Antioxidant Capacity of Bacillus and Planococcus Species Isolated From Saline Lake Environment

et al. 2020

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This study aims at exploiting salinity stress as an innovative, simple, and cheap method to enhance the production of antioxidant metabolites and enzymes from bacteria for potential application as functional additives to foods and pharmaceuticals. We investigated the physiological and biochemical responses of four bacterial isolates, which exhibited high tolerance to 20% NaCl (wt/vol), out of 27 bacterial strains isolated from Aushazia Lake, Qassim region, Saudi Arabia. The phylogenetic analysis of the 16S rRNA genes of these four isolates indicated that strains ST1 and ST2 belong to genus Bacillus, whereas strains ST3 and ST4 belong to genus Planococcus. Salinity stress differentially induced oxidative damage, where strains ST3 and ST4 showed increased lipid peroxidation, lipoxygenase, and xanthine oxidase levels. Consequently, high antioxidant contents were produced to control oxidative stress, particularly in ST3 and ST4. These two Planococcus strains showed increased glutathione cycle, phenols, flavonoids, antioxidant capacity, catalase, and/or superoxide dismutase (SOD). Interestingly, the production of glutathione by Planococcus strains was some thousand folds greater than by higher plants. On the other hand, the induction of antioxidants in ST1 and ST2 was restricted to phenols, flavonoids, peroxidase, glutaredoxin, and/or SOD. The hierarchical analysis also supported strain-specific responses. This is the first report that exploited salinity stress for promoting the production of antioxidants from bacterial isolates, which can be utilized as postbiotics for promising applications in foods and pharmaceuticals.

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Physiological and biochemical responses to aluminum-induced oxidative stress in two cyanobacterial species

Cited by 35 publications

References 53 publications

Heat stress as an innovative approach to enhance the antioxidant production in Pseudooceanicola and Bacillus isolates

Heat stress as an innovative approach to enhance the antioxidant production in Pseudooceanicola and Bacillus isolates

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

Salinity Stress Enhances the Antioxidant Capacity of Bacillus and Planococcus Species Isolated From Saline Lake Environment

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