Physiological and Pathological Influences on Serum Monoamine Oxidase Level: Effect of Age, Sex, Contraceptive Steroids and Diabetes Mellitus

Tryding, Nils; Nilsson, Sven Erik G.; Tufvesson, G.; Berg, R. J. Van Den; Carlström, Sven; Elmfors, Bengt; Nilsson, Jeanette

doi:10.3109/00365516909078089

Cited by 63 publications

(17 citation statements)

References 7 publications

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“…This indicates that sex steroids and prolactin, at least at high concentrations, may be involved in the regulation of sVAP-1 activity, most likely in concert with other, unidentified factors. Interestingly, similar effects of sex and contraceptive steroids on serum monoamine oxidase levels, which largely corresponds to sVAP-1 activity, have been noted almost 35 years ago 33 (although both the early enzymological and statistical methodology suffers from certain limitations) but has been ignored ever since. Because the contribution of many cardiovascular risk factors (eg, smoking 34 ) differ between men and women, and sex is included as a parameter in all major cardiovascular risk scores, we believe that separate analyses for sVAP-1 in men and women are warranted.…”

Section: Discussionmentioning

confidence: 99%

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Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Aalto

Maksimow

Juonala

et al. 2012

ATVB

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Objective-Vascular adhesion protein-1 is an endothelial enzyme that regulates leukocyte traffic and contributes to vascular damage in animal models. The relations of soluble vascular adhesion protein-1 (sVAP-1) with cardiovascular risk factors and markers of subclinical atherosclerosis at a population level have not been studied. Key Words: adhesion molecules Ⅲ atherosclerosis Ⅲ epidemiology Ⅲ risk factors M igration of leukocytes from the blood into the vascular wall is important for the pathogenesis of atherosclerosis. 1,2 Adhesion molecules on the endothelial surface guide immigration of blood-borne leukocytes to various tissues, including vascular wall. Expression of many of these endothelial adhesion molecules is induced in inflammation. Most endothelial adhesion molecules are also found in plasma as soluble forms. 3 They are normally formed by shedding of the surface-bound molecules or by expression of alternatively spliced variants. Therefore, considerable interest has risen in the possibility of using soluble adhesion molecules as biomarkers for various inflammatory diseases, including atherosclerosis. 4 Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule involved in leukocyte migration from the blood into sites of inflammation. 5 In contrast to many other adhesion molecules, it is a cell-surface expressed enzyme. It belongs to semicarbazide-sensitive amine oxidases (also known as primary amine oxidases) that harbor oxidase activity in their extracellular domains. 6 VAP-1 oxidatively deaminates primary amines into aldehydes in a reaction that also produces hydrogen peroxide and ammonium. The enzymatic activity of VAP-1 is important for its adhesive function, 7,8 and it also modulates the inflammatory microenvironment through regulation of transcription factors, chemokines, and other adhesion molecules. 9 -11 Nevertheless, the biological end-products of VAP-1 catalyzed reaction are potentially cytotoxic at higher concentrations, and they are implied in the development of different vasculopathies. For instance, the involvement of VAP-1 in the production of endogenous aldehydes, reactive oxygen species, and advanced glycation end products and in the regulation of arterial structure have been proposed to lead to vascular damage in cellular and animal models. [12][13][14][15] A soluble form of VAP-1 (sVAP-1) is normally present in plasma. 16 The level of sVAP-1 is increased in certain inflam- Analyses of animal models and specific diseases thus suggest that VAP-1 may be involved in cardiovascular damage, but this has never been addressed at a population level. Here we developed a new high-throughput method for determining sVAP-1 activity in serum samples and correlated it to different cardiovascular risk factors and markers of subclinical atherosclerosis in a thoroughly characterized cohort of 2183 young Finns. Methods Study Subjects and Serum SamplesThe study cohort was from the Cardiovascular Risk in Young Finns Study. 25 It includes 3596 persons recruited in 1980 who have been exte...

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Section: Discussionmentioning

confidence: 99%

“…17,33,58,59 In fact, sVAP-1 activity seems to predict the extent of vascular complications in these diseases, 19,37 and even be an independent risk factor for death in type 2 diabetics. 60 In diabetic patients, sVAP-1 correlates directly with the severity of carotid stenosis and with the carotid plaques.…”

Section: Discussionmentioning

confidence: 99%

Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Aalto

Maksimow

Juonala

et al. 2012

ATVB

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“…[1974] ob served an elevation of platelet MAO activity during the ovulatory phase. Oral contraceptive therapy has also been reported either not to affect or to decrease platelet MAO activity [Tryding et al, 1969;Feldman and Roche. 1976].…”

Section: Introductionmentioning

confidence: 99%

Platelet Monoamine Oxidase Activity and Plasma 3,4-Dihydroxy-phenylethylene Glycol Levels during the Menstrual Cycle

et al. 1985

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The influence of endocrine factors on monoamine oxidase activity (MAO) and on noradrenaline metabolism has been evaluated by measuring platelet MAO activity and plasma levels of 3,4-dihydroxyphenylethylene glycol (DOPEG), the major deaminated metabolite of noradrenaline, as well as serum levels of steroid hormones weekly in 9 young healthy women during one menstrual cycle. A decrease in platelet MAO activity (correlated with high serum estradiol levels) was observed during the ovulatory period. In contrast, plasma free or sulfoconjugated DOPEG remained unchanged throughout the menstrual cycle. These results indicate that the hormonal status should be taken into consideration in studies dealing with platelet MAO activity in depressed women.

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“…E-mail: yup@sask.usask.ca. 2 Abbreviations used: SSAO, semicarbazide-sensitive amine oxidase (EC 1.4.3.6); MAO, monoamine oxidase (EC 1.4.3.4); DNPH, mally high in diabetic patients (12)(13)(14), as well as in diabetic animals (15). More recently, plasma SSAO was also found to be elevated in patients with congestive heart failure (16).…”

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confidence: 99%

Assessment of the Deamination of Aminoacetone, an Endogenous Substrate for Semicarbazide-Sensitive Amine Oxidase

Deng

1999

Analytical Biochemistry

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Physiological and Pathological Influences on Serum Monoamine Oxidase Level: Effect of Age, Sex, Contraceptive Steroids and Diabetes Mellitus

Cited by 63 publications

References 7 publications

Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Soluble Vascular Adhesion Protein-1 Correlates With Cardiovascular Risk Factors and Early Atherosclerotic Manifestations

Platelet Monoamine Oxidase Activity and Plasma 3,4-Dihydroxy-phenylethylene Glycol Levels during the Menstrual Cycle

Assessment of the Deamination of Aminoacetone, an Endogenous Substrate for Semicarbazide-Sensitive Amine Oxidase

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