Physiological and proteomic evidences that domestication process differentially modulates the immune status of juvenile Eurasian perch (Perca fluviatilis) under chronic confinement stress

Douxfils, Jonathan; Mathieu, Chantal; Mandiki, Syaghalirwa N.M.; Milla, Sylvain; Henrotte, Emilie; Wang, N.; Vandecan, Michaël; Dieu, Marc; Dauchot, Nicolas; Pigneur, Lise-Marie; Li, X.; Rougeot, Carole; Mélard, Charles; Silvestre, Frédéric; Doninck, Karine Van; Raes, Martine; Kestemont, Patrick

doi:10.1016/j.fsi.2011.10.001

Cited by 42 publications

(30 citation statements)

References 73 publications

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“…In the process of domestication of rainbow trout, the genes involved in immune function were affected [49]. Eurasian perch has also experiences changes in the immune response including changes in serum proteins related to innate/specific immunity and acute phase response [50], and differentially modulates the immune status of juvenile Eurasian perch, due to increased chronic stress by confinement [51, 52]. Many studies have supported a mechanistic link between behavior and gene expression, since changes in gene expression levels will cause phenotype variations [53, 54].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have supported a mechanistic link between behavior and gene expression, since changes in gene expression levels will cause phenotype variations [53, 54]. To maximize profitability, domesticated Eurasian perch were cultured in intensive farming conditions with limited space, high density, dead pond water, and other stressors, which would have led to large-scale disease [50, 51, 55]. Long-term artificial selection of individuals with high immune performance improved the survival rate of these cultured fish, which may explain the high expression of immune related genes observed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, some proteolytic enzymes and some digestive related genes ( try1 , ctr l, ctrb , etc) involved in protein digestion and absorption metabolic pathway were only lowly expressed (Figs 2 and 5) in domesticated Eurasian perch, may be the result of a captive diet. These captive fish are no longer under strong selection pressure to maximize absorption of limited resources, such as protein, so although these enzymes and metabolic pathways may be more effective in protein digestion, they are less active in domesticated perch [15, 51]. …”

Section: Discussionmentioning

confidence: 99%

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Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis)

et al. 2017

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Domestication has altered a variety of traits within the Eurasian perch (Perca fluviatilis), including phenotypic, physiological and behavioral traits of Eurasian perch (Perca fluviatilis). Little is known, however, about the genetic changes between domesticated and wild Eurasian perch. In this study, we assembled a high-quality de novo reference transcriptome and identified differentially expressed genes between wild and domesticated Eurasian perch. A total of 113,709 transcripts were assembled, and 58,380 transcripts were annotated. Transcriptomic comparison revealed 630 differentially expressed genes between domesticated and wild Eurasian perch. Within domesticated Eurasian perch there were 412 genes that were up-regulated including MHCI, MHCII, chia, ighm within immune system development. There were 218 genes including try1, ctrl, ctrb, cela3b, cpa1 and cpb1, which were down-regulated that were associated with digestive processes. Our results indicated domestication drives the changes of immune and digestive system of Eurasian perch. Our study not only provide valuable genetic resources for further studies in Eurasian perch, but also provide novel insights into the genetic basis of physiological changes in Eurasian perch during domestication process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis)

et al. 2017

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“…Thus, it has been shown that stressed fish have decreased activity of complement, hemagglutination, and reduction of circulating lymphocytes [11, 12]. Decreases in C3 complement component protein levels [13] and decrease in expression of immune-relevant genes [14, 15] have also been found.…”

Section: Introductionmentioning

confidence: 99%

Effects of Cortisol Administered through Slow-Release Implants on Innate Immune Responses in Rainbow Trout (Oncorhynchus mykiss)

Cortés

Teles

Tridico

et al. 2013

International Journal of Genomics

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Cortisol is a key hormone in the fish stress response with a well-known ability to regulate several physiological functions, including energy metabolism and the immune system. However, data concerning cortisol effects on fish innate immune system using a more controlled increase in cortisol levels isolated from any other stress related signaling is scarce. The present study describes the effect of doses of cortisol corresponding to acute and chronic levels on the complement and lysozyme activity in plasma of the rainbow trout (Oncorhynchus mykiss). We also evaluated the effects of these cortisol levels (from intraperitoneally implanted hydrocortisone) on the mRNA levels quantified by RT-qPCR of selected key immune-related genes in the liver, head kidney, and spleen. For that purpose, 60 specimens of rainbow trout were divided in to two groups: a control group injected with a coconut oil implant and another group injected with the same implant and cortisol (50 μg cortisol/g body weight). Our results demonstrate the role of cortisol as a modulator of the innate immune response without the direct contribution of other stress axes. Our results also show a relationship between the complement and lysozyme activity in plasma and mRNA levels in liver, supporting the important role of this organ in producing these immune system proteins after a rise of cortisol in the fish plasma.

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“…Here most are on health aspects, with focus on viral diseases [41,[110][111][112][113][114][115][116][117][118], bacterial diseases [38,110,[119][120][121][122][123][124][125][126][127][128] and vaccine development [39,[129][130][131][132][133][134][135][136][137][138] but also parasites [139][140][141], hepatic tumours [142] and skeletal deformities in fish [34] have been studied. Besides these, immunoproteomic studies also encompass results on immunostimulants [35], antimicrobial peptides [143][144][145] and composition of mucosal secretions [146,147], along with other topics related to a better understanding of mechanistic aspects of immune responses to certain stimuli [40,[148]…”

mentioning

confidence: 99%

PROTEOMICS in aquaculture: Applications and trends

Rodrigues

Silva

Dias

et al. 2012

Journal of Proteomics

123

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Physiological and proteomic evidences that domestication process differentially modulates the immune status of juvenile Eurasian perch (Perca fluviatilis) under chronic confinement stress

Cited by 42 publications

References 73 publications

Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis)

Domestication drive the changes of immune and digestive system of Eurasian perch (Perca fluviatilis)

Effects of Cortisol Administered through Slow-Release Implants on Innate Immune Responses in Rainbow Trout (Oncorhynchus mykiss)

PROTEOMICS in aquaculture: Applications and trends

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