Physiological and proteomic responses to corticosteroid treatments in Eurasian perch, Perca fluviatilis : Investigation of immune-related parameters

Milla, Sylvain; Massart, Sophie; Mathieu, C.; Wang, Neil; Douny, Caroline; Douxfils, Jessica; Scippo, Marie Louise; Pauw, Edwin De; Dieu, Marc; Silvestre, Frédéric; Kestemont, Patrick

doi:10.1016/j.cbd.2017.11.005

Cited by 5 publications

(2 citation statements)

References 75 publications

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“…Regarding metabolism, we found that biological processes related to the ATP biosynthesis of glycolysis/gluconeogenesis (aldoa and idh2) could indicate a need for an energy supply for stress conditions in fish [62,63]. In agreement with these findings, Milla et al found that DOC induces physiological and proteomic responses related to the immune response in the spleen of Eurasian perch (Perca fluviatilis), as well as in the proteins involved in the Krebs cycle and glucose metabolism in the liver [64]. Carbohydrate metabolism appears to play an important part in the energy supply for osmoregulation [65], which is crucial during stress.…”

Section: Discussionsupporting

confidence: 77%

11-Deoxycorticosterone (DOC)’s Action on the Gill Osmoregulation of Juvenile Rainbow Trout (Oncorhynchus mykiss)

Zuloaga,

Ahumada-Langer,

Aedo

et al. 2024

Biology

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In aquaculture, stress can negatively affect fish growth. For years, the cortisol hormone has been thought to play both glucocorticoid and mineralocorticoid functions. Nevertheless, recent research has suggested that 11-deoxycorticosterone (DOC) released during stress could contribute to cortisol actions, though this process is still misunderstood. Here, we evaluated the DOC effects on physiological and early transcriptional responses by RNA-seq. Juvenile rainbow trout were treated with DOC and/or glucocorticoids (mifepristone) or mineralocorticoid (eplerenone) receptor antagonists. Subsequently, plasma was collected, and cDNA libraries were generated from the gills of vehicle (control), DOC, mifepristone, mifepristone with DOC, eplerenone, and eplerenone with DOC groups. Calcium and phosphate levels in plasma were changed. Results revealed 914 differentially expressed transcripts (DETs) induced by DOC compared with control, mainly associated with sodium ion transmembrane transport, gluconeogenesis, negative regulation of transmembrane transport, and activation of innate immune response. DOC versus eplerenone with DOC comparison displayed 444 DETs related to cell-cell junction organization, canonical glycolysis, positive regulation of immune response, and potassium ion transport. Conversely, no DETs were detected in DOC versus mifepristone with DOC comparison. These data suggest that DOC has a relevant role in gill stress response and ion transport, which is differentially regulated by mineralocorticoid receptors.

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Section: Discussionsupporting

confidence: 77%

11-Deoxycorticosterone (DOC)’s Action on the Gill Osmoregulation of Juvenile Rainbow Trout (Oncorhynchus mykiss)

Zuloaga,

Ahumada-Langer,

Aedo

et al. 2024

Biology

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show abstract

“…On the one hand, DOC boosts Na + /K + -ATPase activity in order to produce sufficient ATP to sustain the accelerated respiratory behavior (Kiilerich et al, 2011). On the other hand, DOC is an endocrine regulator to maintain the immune balance during reproduction (Mathieu et al, 2013;Milla et al, 2018). For example, DOC can minimize the negative consequence of the occurring oxidative stress.…”

Section: Potential Mechanisms Linking Reproduction and Respiratory Plasticitymentioning

confidence: 99%

Plasticity of Respiratory Function Accommodates High Oxygen Demand in Breeding Sea Cucumbers

Zhang

Liu

et al. 2020

Front. Physiol.

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Physiological plasticity allows animals to adjust their physiological function to abiotic and biotic variations. It has been mostly studied in the context of response to external factors and not much is known on how animals adjust their physiology to cope with variations in internal conditions. The process of reproduction implies gonadal maturation and other internal changes, bringing various challenges to the animal such as an increased demand for energy and oxygen. Here, the capacity of the sea cucumber, Apostichopus japonicus to adjust its respiratory function and physiological mechanisms during reproduction was studied using a time-lapse videography and metabolomics approach. The results showed that reproduction caused a significant increase in oxygen consumption in A. japonicus. Interestingly, breeding sea cucumbers can accommodate the high oxygen demand by accelerating respiratory rate. However, to maintain a necessary high level of respiratory activity during reproduction, sea cucumbers need consume large amounts of adenosine triphosphate (ATP). In addition, the metabolomic data suggests that oxidative stress and hormone regulation are the physiological mechanisms linking reproduction and respiratory function. Altogether, these findings suggest that plasticity of respiratory function is an effective tactic to cope with high oxygen demand during reproduction.

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Early metabolic and transcriptomic regulation in rainbow trout (Oncorhynchus mykiss) liver by 11-deoxycorticosterone through two corticosteroid receptors pathways

Zuloaga,

Ahumada-Langer,

Aedo

et al. 2024

Comparative Biochemistry and Physiology Part A: Molecular &

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Physiological and proteomic responses to corticosteroid treatments in Eurasian perch, Perca fluviatilis : Investigation of immune-related parameters

Cited by 5 publications

References 75 publications

11-Deoxycorticosterone (DOC)’s Action on the Gill Osmoregulation of Juvenile Rainbow Trout (Oncorhynchus mykiss)

11-Deoxycorticosterone (DOC)’s Action on the Gill Osmoregulation of Juvenile Rainbow Trout (Oncorhynchus mykiss)

Plasticity of Respiratory Function Accommodates High Oxygen Demand in Breeding Sea Cucumbers

Early metabolic and transcriptomic regulation in rainbow trout (Oncorhynchus mykiss) liver by 11-deoxycorticosterone through two corticosteroid receptors pathways

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