Physiological Challenges for Intracortical Electrodes

Groothuis, Jitte; Ramsey, Nick F.; Ramakers, G.J.A.; Plasse, G

doi:10.1016/j.brs.2013.07.001

Cited by 59 publications

(57 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one study, (Groothuis J, et al, 2014) it was suggested that a foreign body response to the presence of stimulating electrodes in the brain could result in electrical malfunction of the electrode and neuronal loss.…”

Section: Discussionmentioning

confidence: 99%

Cellular immunologic responses to cochlear implantation in the human

Nadol¹,

O’Malley²,

Burgess³

et al. 2014

Hearing Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Cellular immunologic responses to cochlear implantation in the human

Nadol¹,

O’Malley²,

Burgess³

et al. 2014

Hearing Research

View full text Add to dashboard Cite

“…Second, prior work on neuroprosthetic devices appears to suggest that continuous delivery of DEX might not be necessary for long-term benefits. [43][44][45] Needle pricks performed 10 days after probe insertion induced clear K + spikes and corresponding glucose dips ( Figure 6): 87% of the fifteen K + spikes were accompanied by a quantifiable glucose dip (Table 1). Figure 6 confirms that the benefits of DEX retrodialysis for monitoring K + and glucose in the context of SD outlast the DEX retrodialysis itself.…”

Section: Sd-associated Transients 10 Days After Probe Insertion Micrmentioning

confidence: 99%

Enhancing Continuous Online Microdialysis Using Dexamethasone: Measurement of Dynamic Neurometabolic Changes during Spreading Depolarization

Varner

Leong

Jaquins-Gerstl

et al. 2017

ACS Chem. Neurosci.

View full text Add to dashboard Cite

Microdialysis is well established in chemical neuroscience as a mainstay technology for real time intracranial chemical monitoring in both animal models and human patients. The capabilities of microdialysis sampling have the potential to be further enhanced through mitigation of the penetration injury unavoidably caused by the insertion of microdialysis probes into brain tissue. Herein, we show that dexamethasone retrodialysis in the rat cortex enhances the microdialysis detection of K+ and glucose transients induced by spreading depolarization. Once inserted, the probes were perfused continuously (1.67 μL/min) either with or without dexamethasone. Without dexamethasone, glucose transients were too small to reliably quantify at 5 days after probe insertion. With dexamethasone, robust K+ and glucose transients were readily quantified at 2 hrs, 5 days, and 10 days after probe insertion. Although the amplitudes of the K+ transients declined day-to-day following probe insertion, amplitudes of the glucose transients were consistent. Immunohistochemistry and fluorescence microscopy confirm that dexamethasone is highly effective at preventing ischemia and gliosis in the vicinity of microdialysis probes implanted for 10 days.

show abstract

“…[6] Insertion of electrodes into the brain leads to damage of blood vessels, capillaries, and cells, and breaches the highly selective blood-brain barrier. [7] Less destructive non-invasive neural recording techniques such as fMRI, fNIRS, and EEG avoid tissue reactions at the expense of spatial and temporal resolution and are not currently portable therefore they are not suitable for BMI applications. [8] Additionally, none of these methods are capable of stimulating neural tissue.…”

Section: Introductionmentioning

confidence: 99%

“…[11] Initial damage sends the signal for microglial activation and migration to the implantation site, which, if tissue irritation continues, progresses until microglia form the dense glial sheath that is a familiar detriment to chronic neural communication. [7] Additionally, long-term breach of the highly-selective blood-brain barrier (BBB) eventually leads to secretion of neurotoxins that kill neurons proximal to the electrode, thereby diminishing the signal of interest permanently. [12] Contributing factors believed to adversely affect the quality of the electrode-tissue interface in a chronic time window include electrode size, [13,14] density of electrode material, [15] skull tethering mechanisms and associated micromotion of the implant, [16] and mechanical compliance of the electrode itself.…”

Section: Introductionmentioning

confidence: 99%

Soft, Flexible Freestanding Neural Stimulation and Recording Electrodes Fabricated from Reduced Graphene Oxide

Apollo

Maturana

Tong

et al. 2015

Adv Funct Materials

131

148

View full text Add to dashboard Cite

. (2015). Soft, flexible freestanding neural stimulation and recording electrodes fabricated from reduced graphene oxide. Advanced Functional Materials, 25 (23), 3551-3559. Soft, flexible freestanding neural stimulation and recording electrodes fabricated from reduced graphene oxide AbstractThere is an urgent need for conductive neural interfacing materials that exhibit mechanically compliant properties, while also retaining high strength and durability under physiological conditions. Currently, implantable electrode systems designed to stimulate and record neural activity are composed of rigid materials such as crystalline silicon and noble metals. While these materials are strong and chemically stable, their intrinsic stiffness and density induce glial scarring and eventual loss of electrode function in vivo. Conductive composites, such as polymers and hydrogels, have excellent electrochemical and mechanical properties, but are electrodeposited onto rigid and dense metallic substrates. In the work described here, strong and conductive microfibers (40-50 μm diameter) wet-spun from liquid crystalline dispersions of graphene oxide are fabricated into freestanding neural stimulation electrodes. The fibers are insulated with parylene-C and laser-treated, forming "brush" electrodes with diameters over 3.5 times that of the fiber shank. The fabrication method is fast, repeatable, and scalable for high-density 3D array structures and does not require additional welding or attachment of larger electrodes to wires. The electrodes are characterized electrochemically and used to stimulate live retina in vitro. Additionally, the electrodes are coated in a water-soluble sugar microneedle for implantation into, and subsequent recording from, visual cortex. AbstractThere is an urgent need for conductive neural interfacing materials that exhibit mechanicallycompliant properties while also retaining high strength and durability in physiological conditions. Currently, implantable electrode systems designed to stimulate and record neural activity are comprised of rigid materials such as crystalline silicon and noble metals. While these materials are strong and chemically stable, their intrinsic stiffness and density induce glial scarring and eventual loss of electrode function in vivo. Conductive composites, such as polymers and hydrogels, have excellent electrochemical and mechanical properties, but are electrodeposited onto rigid and dense metallic substrates. In the work described here, strong and conductive microfibres (40-50 µm diameter) wet-spun from liquid crystalline dispersions of graphene oxide are fabricated into freestanding neural stimulation electrodes. The fibres were insulated with parylene-C and laser-treated, forming "brush" electrodes with diameters over 3.5 times that of the fibre shank. The fabrication method is fast, repeatable, and scalable for high density 3-D array structures and does not require additional welding or attachment of larger electrodes to wires. The electrodes are characterized electroch...

show abstract

Physiological Challenges for Intracortical Electrodes

Cited by 59 publications

References 62 publications

Cellular immunologic responses to cochlear implantation in the human

Cellular immunologic responses to cochlear implantation in the human

Enhancing Continuous Online Microdialysis Using Dexamethasone: Measurement of Dynamic Neurometabolic Changes during Spreading Depolarization

Soft, Flexible Freestanding Neural Stimulation and Recording Electrodes Fabricated from Reduced Graphene Oxide

Contact Info

Product

Resources

About