Physiological influence of iron-hydroxide polymaltosis complex on development of sexual function in white rats

Deltsov, Alexander A.; Maksimov, V. I.; Балакирев, Н.А.; Козлов, С. А.; Ippolitova, T.

doi:10.30896/0042-4846.2019.22.2.45-50

Cited by 2 publications

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“…In most cases, the disease is caused by animal nutrition and management. Causes of iron deficiency anemia are similar [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Existing iron-containing preparations can be systematized depending on the method of absorption of iron from preparations: including Fe 2+ (ionic, salt compounds of iron); including Fe 3+ (non-ionic iron compounds). Iron, most commonly, is in bivalent form when absorbed from ionic compounds, while the pH value of gastric juice severely limits the activity of utilization of iron products in trivalent form [1,3,10,12].…”

Section: Introductionmentioning

confidence: 99%

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Ways to develop and improve a pharmacologically active compound based on a polymer complex for the prevention and treatment of microelementosis in fur farming

2020

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The analysis of iron-containing products made in Russia for veterinarian use against iron deficiency anaemia in fur farming was carried out. The absence of hydroxide-polymaltose iron complexes on the pharmaceutical market has been shown and their promise as the main components for oral preparations has been substantiated. In this context, the Collective of the Department of Physiology, Pharmacology and Toxicology, FSBEI HE MGAVMiB-MVA named after K.I. Skryabin, in collaboration with the research and production company A-BIO conducted research to develop and study the effect of pharmacologically active compounds based on a polymer (iron-hydroxide polymantose) complex for treatment and prevention of microelemetosis in the fur animals.

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“…In most cases, the disease is caused by animal nutrition and management. Causes of iron deficiency anemia are similar [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ways to develop and improve a pharmacologically active compound based on a polymer complex for the prevention and treatment of microelementosis in fur farming

2020

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The study of acute toxicity and some clinical parameters of a new chelated compound

Yugatova,

Vasiliev,

Nazarova

et al. 2024

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The parameters of acute toxicity of a chelate complex containing microelements: iron, manganese, copper, selenium, iodine was studied on outbred male rats. Toxic doses were determined by constructing a direct regression graph. Thus, groups of animals were formed that were administered an aqueous solution of the chelate complex in doses, ml/kg: 6.94; 8.89; 11.11 and 11.67. The response to the solution was assessed using generally accepted clinical and hematological methods. At the same time, the dynamics of temperature, live weight, mortality and peripheral blood parameters were taken into account. During the experiment, toxicity indicators were determined. The toxic effect in experimental animals manifested itself in the form of inhibition of activity, shortness of breath, decreased reactions to external stimuli, decreased body temperature, ruffled coat, and weight loss. In the blood, a significant increase in the number of leukocytes and erythrocytes was noted in rats receiving subsidies of the chelate microelement complex in doses of 8.89 ml/kg and 11.11 ml/kg. It was concluded that the introduction of a chelate complex of microelements led to stimulation of erythropoiesis and leukopoiesis, and according to the results of a study of toxicity indicators, the presented formulation corresponds to the 3rd hazard class. The parameters of acute toxicity of the chelate complex of microelements were determined, taking into account the survival of animals, LD50 was established - 907 ± 0.63 mg/kg; LD16 – 765 mg/kg; LD84 – 1076 mg/kg. It was concluded that the toxicity indicators of the chelate complex of microelements according to GOST 12.1.007–76 correspond to the 3rd hazard class - “moderately hazardous substances”. Considering the potential hematopoietic and antioxidant effect of trace elements in the chelate complex and the relatively low toxicity with other seleniumcontaining organic and inorganic additives and preparations, the use of this complex opens up opportunities and prospects for testing as a radioprotective agent.

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Physiological influence of iron-hydroxide polymaltosis complex on development of sexual function in white rats

Cited by 2 publications

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Ways to develop and improve a pharmacologically active compound based on a polymer complex for the prevention and treatment of microelementosis in fur farming

Ways to develop and improve a pharmacologically active compound based on a polymer complex for the prevention and treatment of microelementosis in fur farming

The study of acute toxicity and some clinical parameters of a new chelated compound

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